PolmanCHO’ConnorPHavrdovaE. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med2006; 354: 899–910.
2.
KapposLRadueEWO’ConnorP.; FREEDOMS Study Group. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med2010; 362: 387–401.
3.
GoldRKapposLArnoldDL.; DEFINE Study Investigators. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med2012; 367: 1098–1107.
4.
JacobsLDCookfairDLRudickRA.; The Multiple Sclerosis Collaborative Research Group (MSCRG). Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol1996; 39: 285–294.
5.
PRISMS Study Group. Randomised double-blind placebo-controlled study of interferon-1a in relapsing/remitting multiple sclerosis. Lancet1998; 352: 1498–1504.
6.
MillerDHSoonDFernandoKT.; AFFIRM Investigators. MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS. Neurology2007; 68: 1390–1401.
7.
LiDKPatyDWMagnetic resonance imaging results of the PRISMS trial: a randomized, double-blind, placebo-controlled study of interferon-beta1a in relapsing-remitting multiple sclerosis. Prevention of Relapses and Disability by Interferon-beta1a Subcutaneously in Multiple Sclerosis. Ann Neurol1999; 46: 197–206.
8.
ComiGMartinelliVRodegherM.; PreCISe study group. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet2009; 374: 1503–1511.
9.
CohenJABarkhofFComiGC. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med2010; 362: 402–415.
10.
FoxRMillerDHPhillipsJT. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med2012; 367: 1087–1097.
11.
ShiraniAZhaoYKarimME. Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis. JAMA2012; 308: 247–256.
12.
TrojanoMPellegriniFFuianiA. New natural history of interferon-treated relapsing multiple sclerosis. Ann Neurol2007; 61: 300–306.
13.
TedeholmHLyckeJSkoogB. Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs. Mult Scler J2012; Nov1 (epub ahead of print).
14.
International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature2011; 476: 14–19.
15.
HavrdovaEGalettaSStefoskiD. Freedom from disease activity in multiple sclerosis. Neurology2010; 74(Suppl 3): S3–S7.