Background/Objective: A clinically isolated syndrome compatible with demyelination (CIS) is the initial presentation for the majority of people that go on to develop multiple sclerosis (MS). There has previously been little work examining the effect of gender on the development and progression of CIS.
Methods: Data from observational studies of CIS were used. In total, 33 suitable studies with 4732 subjects were identified.
Results: The overall relative risk (RR) of CIS in females compared with males was 2.12 (95% CI 1.94–2.32). The RR of females developing MS following CIS was 1.20 (95% CI 0.98–1.46) compared with males.
Conclusions: These data imply that the gender bias seen in MS is caused by factors acting early in the disease process.
ChardDTDaltonCMSwantonJ. MRI only conversion to multiple sclerosis following a clinically isolated syndrome. J Neurol Neurosurg Psychiatry2011; 82: 176-179
6.
LiuYDuanYYuC. Clinical isolated syndrome: A 3-year follow-up study in China. Clin Neurol Neurosurg2011; in press.
7.
RuetADeloireMSOualletJC. Predictive factors for multiple sclerosis in patients with clinically isolated spinal cord syndrome. Mult Scler2011; 17: 312-318
8.
BoscaIMagranerMJCoretF. The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands. J Neuroimmunol2010; 226: 143-146
9.
BrettschneiderJCzerwoniakASenelM. The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS). PLoS One2010; 5: e11986
10.
Di FilippoMAndersonVMAltmannDR. Brain atrophy and lesion load measures over 1 year relate to clinical status after 6 years in patients with clinically isolated syndromes. J Neurol Neurosurg Psychiatry2010; 81: 204-208
11.
Oligoclonal bands and MRI in clinically isolated syndromes: predicting conversion time to multiple sclerosis. J Neurol2010; 257: 1188-1191
12.
SwantonJKFernandoKTDaltonCM. Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis. Mult Scler2010; 16: 156-165
13.
TintoreMRoviraAArrambideG. Brainstem lesions in clinically isolated syndromes. Neurology2010; 75: 1933-1938
14.
TaylorBVLucasRMDearK. Latitudinal variation in incidence and type of first central nervous system demyelinating events. Mult Scler2010; 16: 398-405
15.
BrettschneiderJTumaniHKiechleU. IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome. PLoS One2009; 4: e7638
16.
JafariNHoppenbrouwersIHopW. Cigarette smoking and risk of MS in multiplex families. Mult Scler2009; 15: 1363-1367
17.
LoCPKaoHWChenSY. Prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis according to baseline MRI findings: comparison of revised McDonald criteria and Swanton modified criteria. J Neurol Neurosurg Psychiatry2009; 80: 1107-1109
18.
MowryEMPesicMGrimesB. Clinical predictors of early second event in patients with clinically isolated syndrome. J Neurol2009; 256: 1061-1066
19.
OutteryckOZephirHDefoortS. Optical coherence tomography in clinically isolated syndrome: no evidence of subclinical retinal axonal loss. Arch Neurol2009; 66: 1373-1377
20.
YoungJQuinnSHurrellMTaylorB. Clinically isolated acute transverse myelitis: prognostic features and incidence. Mult Scler2009; 15: 1295-1302
21.
ZephirHLefrancDDubucquoiS. Serum IgG repertoire in clinically isolated syndrome predicts multiple sclerosis. Mult Scler2009; 15: 593-600
22.
Di PauliFReindlMEhlingR. Smoking is a risk factor for early conversion to clinically definite multiple sclerosis. Mult Scler2008; 14: 1026-1030
23.
JacobiCHahnelSMartinez-TorresF. Prospective combined brain and spinal cord MRI in clinically isolated syndromes and possible early multiple sclerosis: impact on dissemination in space and time. Eur J Neurol2008; 15: 1359-1364
24.
Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol2008; 65: 727-732
25.
RoccaMAAgostaFSormaniMP. A three-year, multi-parametric MRI study in patients at presentation with CIS. J Neurol2008; 255: 683-691
26.
SellnerJLuthiNBuhlerR. Acute partial transverse myelitis: risk factors for conversion to multiple sclerosis. Eur J Neurol2008; 15: 398-405
27.
GreeveISellnerJLauterburgT. Anti-myelin antibodies in clinically isolated syndrome indicate the risk of multiple sclerosis in a Swiss cohort. Acta Neurologica Scandinavica2007; 116: 207-210
28.
SwantonJKRoviraATintoreM. MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol2007; 6: 677-686
29.
TomassiniVDe GiglioLReindlM. Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS. Mult Scler2007; 13: 1086-1094
30.
BrettschneiderJPetzoldAJunkerATumaniH. Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis. Mult Scler2006; 12: 143-148
31.
KortewegTTintoreMUitdehaagB. MRI criteria for dissemination in space in patients with clinically isolated syndromes: a multicentre follow-up study. Lancet Neurol2006; 5: 221-227
32.
MasjuanJAlvarez-CermenoJCGarcia-BarraganN. Clinically isolated syndromes: a new oligoclonal band test accurately predicts conversion to MS. Neurology2006; 66: 576-578
33.
TintoreMRoviraARioJ. Is optic neuritis more benign than other first attacks in multiple sclerosis?Ann Neurol2005; 57: 210-215
34.
Martinez-YelamosARoviraASanchez-ValleR. CSF 14-3-3 protein assay and MRI as prognostic markers in patients with a clinically isolated syndrome suggestive of MS. J Neurol2004; 251: 1278-1279
35.
ErikssonMAndersenORunmarkerB. Long-term follow-up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis. Mult Scler2003; 9: 260-274
36.
Sastre-GarrigaJTintoreMRoviraA. Conversion to multiple sclerosis after a clinically isolated syndrome of the brainstem: cranial magnetic resonance imaging, cerebrospinal fluid and neurophysiological findings. Multiple Sclerosis. 2003; 9: 39-43
37.
TintoreMRoviraABrievaL. Isolated demyelinating syndromes: comparison of CSF oligoclonal bands and different MR imaging criteria to predict conversion to CDMS. Mult Scler2001; 7: 359-363
38.
HelyMAMcManisPGDoranTJ. Acute optic neuritis: a prospective study of risk factors for multiple sclerosis. J Neurol Neurosurg Psychiatry1986; 49: 1125-1130
39.
Sandberg-WollheimMBynkeHCronqvistS. A long-term prospective study of optic neuritis: evaluation of risk factors. Ann Neurol1990; 27: 386-393
40.
SoderstromMYa-PingJHillertJLinkH. Optic neuritis: prognosis for multiple sclerosis from MRI, CSF, and HLA findings. Neurology1998; 50: 708-714
41.
Koch-HenriksenNSorensenPS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol2010; 9: 520-532
42.
OrtonSHerreraBYeeI. Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol2006; 5: 932-936
43.
Koch-HenriksenN. Increasing incidence of multiple sclerosis in Danish women. Mult Scler2006; 12: S228
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