Abstract
Neuromyelitis optica (NMO), mainly affecting optic nerve and spinal cord, can also manifest diverse ocular symptoms due to brain abnormalities. We present a cortical oscillopsia without nystagmus or head tremor in a patient with neuromyelitis optica spectrum disorder (NMOSD) with anti-aquaporin 4 antibody. This rare ocular manifestation, which is easily underestimated owing to absence of the typical nystagmus, can be an initial manifestation of NMOSD.
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References
1.
Chen
L
Gordon
LK
. Ocular manifestations of multiple sclerosis . Curr Opin Ophthalmol
2005 ; 16 : 315 –320 .
2.
Shaikh
AG
Reich
S
Zee
DS
. Pseudonystagmus – clinical features and quantitative characteristics . Nat Rev Neurol
2010 ; 6 : 519 –523 .
3.
Samart
K
Phanthumchinda
K
. Neuromyelitis optica with hypothalamic involvement: A case report . J Med Assoc Thai
2010 ; 93 : 505 –509 .
4.
Tilikete
C
Vighetto
A
. Oscillopsia: causes and management . Curr Opin Neurol
2011 ; 24 : 38 –43 .
5.
Wingerchuk
DM
Lennon
VA
Lucchinetti
CF
Pittock
SJ
Weinshenker
BG
. The spectrum of neuromyelitis optica . Lancet Neurol
2007 ; 6 : 805 –815 .
6.
Suzuki
Y
Kiyosawa
M
Mochizuki
M
Wakakura
M
Ishii
K
Senda
M
. Oscillopsia associated with dysfunction of visual cortex . Jpn J Ophthalmol
2004 ; 48 : 128 –132 .
7.
Pittock
SJ
. Neuromyelitis optica: a new perspective . Semin Neurol
2008 ; 28 : 95 –104 .
8.
Moon
IS
Kim
JS
Choi
KD
. Isolated nodular infarction . Stroke
2009 ; 40 : 487 –491 .
9.
Lakhanpal
A
Selhorst
JB
. Bilateral altitudinal visual fields . Ann Ophthalmol
1990 ; 22 : 112 –117 .
10.
Deutschlander
A
Hufner
K
Kalla
R
. Unilateral vestibular failure suppresses cortical visual motion processing . Brain
2008 ; 131 : 1025 –1034 .
11.
Kim
JE
Kim
SM
Ahn
SW
. Brain abnormalities in neuromyelitis optica . J Neurol Sci
2011 ; 302 : 43 –48 .
12.
Ito
S
Mori
M
Makino
T
Hayakawa
S
Kuwabara
S
. ‘Cloud-like enhancement’ is a magnetic resonance imaging abnormality specific to neuromyelitis optica . Ann Neurol
2009 ; 66 : 425 –428 .
13.
Kim
SM
Waters
P
Vincent
A
. Sjögren’s syndrome myelopathy: spinal cord involvement in Sjögren’s syndrome might be a manifestation of neuromyelitis optica . Mult Scler
2009 ; 15 : 1062 –1068 .
14.
Waters
P
Jarius
S
Littleton
E
. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis . Arch Neurol
2008 ; 65 : 913 –919 .
15.
Grusser
OJ
Pause
M
Schreiter
U
. Vestibular neurones in the parieto-insular cortex of monkeys (Macaca fascicularis): visual and neck receptor responses . J Physiol
1990 ; 430 : 559 –583 .
16.
Grusser
OJ
Pause
M
Schreiter
U
. Localization and responses of neurones in the parieto-insular vestibular cortex of awake monkeys (Macaca fascicularis ) . J Physiol
1990 ; 430 : 537 –557 .
