McDonaldWI. Pathophysiology in multiple sclerosis. Brain1974; 97: 179–196.
2.
WaxmanSG. Membranes, myelin, and the pathophysiology of multiple sclerosis. N Engl J Med1982; 306: 1529–1533.
3.
FosterREWhalenCCWaxmanSG. Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence. Science1980; 210: 661–663.
4.
CranerMJNewcombeJBlackJAHartleCCuznerMLWaxmanSG. Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc Natl Acad Sci U S A2004; 101: 8168–8173.
5.
DavieCABarkerGJWebbS. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain1995; 118: 1583–1592.
6.
TrappBDPetersonJRansohoffRMRudickRMorkSBoL. Axonal transection in the lesions of multiple sclerosis. N Engl J Med1998; 338: 278–285.
7.
WaxmanSG. Demyelinating diseases—new pathological insights, new therapeutic targets. N Engl J Med1998; 338: 323–325.
AkopianANSivilottiLWoodJN. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature1996; 379: 257–262.
10.
BlackJADib-HajjSBakerDNewcombeJCuznerMLWaxmanSG. Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis. Proc Natl Acad Sci U S A2000; 97: 11598–11602.
11.
RenganathanMGelderblomMBlackJAWaxmanSG. Expression of Nav1.8 sodium channels perturbs the firing patterns of cerebellar Purkinje cells. Brain Res2003; 959: 235–242.
12.
SaabCYCranerMJKataokaYWaxmanSG. Abnormal Purkinje cell activity in vivo in experimental allergic encephalomyelitis. Exp Brain Res2004; 158: 1–8.
13.
FazioFNotartomasoSAronicaE. Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis. Neuropharmacology2008; 55: 491–499.
14.
FerragutiFCrepaldiLNicolettiF. Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol Rev2008; 60: 536–581.
15.
NiswenderCMConnPJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol2010; 50: 295–322.
16.
GerwigMKolbFPTimmannD. The involvement of the human cerebellum in eyeblink conditioning. Cerebellum2007; 6: 38–57.
17.
RaymondJLLisbergerSGMaukMD. The cerebellum: a neuronal learning machine?. Science1996; 272: 1126–1131.
18.
YeoCHHesslowG. Cerebellum and conditioned reflexes. Trends Cogn Sci1998; 2: 322–330.
19.
McEchronMDAlexanderDNSmithMEHoffmanDLPodskalnyGDConnorJR. Altered eyeblink reflex conditioning in restless legs syndrome patients. Sleep Med2010; 11: 314–319.
20.
SolomonPRLevineEBeinTPendleburyWW. Disruption of classical conditioning in patients with Alzheimer’s disease. Neurobiol Aging1991; 12: 283–287.
21.
KimuraJ. Electrically elicited blink reflex in diagnosis of multiple-sclerosis—review of 260 patients over a 7-year period. Brain1975; 98: 413–426.
