Gilmore CP, Cottrell DA, Scolding NJ, Wingerchuk DM, Weinshenker BG, Boggild M.A window of opportunity for no treatment in early MS?Mult Scler2010; [Epub ahead of print].
2.
Frohman EM, Havrdova E., Lublin F., et al. Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis. Arch Neurol2006; 63: 614-619.
3.
Goodin DS, Bates D.Treatment of early multiple sclerosis: the value of treatment initiation after a first clinical episode. Mult Scler2009; 15: 1175-1182.
4.
Pittock SJUncertain BENEFIT of early interferon beta-1b treatment. Lancet Neurol2009; 8: 970-971 (editorial).
5.
Jacobs L., Beck RW, Simon JH, et al. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. N Eng J Med2000; 343: 898-904.
6.
Comi G., Fillippi M., Barkhof F., et al. Effect of early interferon treatment on conversion to clinically definite multiple sclerosis: a randomized study. Lancet2001; 357: 1576-1582.
7.
Kappos L., Polman CH, Freedman MS, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology2006; 67: 1242-1249.
8.
Comi G., Martinelli V., Rodegher M., et al. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet2009; 374: 1503-1511.
9.
Polman CH, Reingold SC, Edan GE, et al. Diagnostic criteria for multiple sclerosis: (2005) Revisions to the ‘McDonald Criteria’. Ann Neurol2005; 58: 840-846.
10.
Dalton CM, Brex PA, Miszkiel KA, et al. Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis. Ann Neurol2002; 52: 47-53.
11.
Tintore M., Rovira A., Rio J., et al. New diagnostic criteria for multiple sclerosis: application in first demyelinating episode. Neurology2003; 60: 27-30.
12.
Miller D., Barkhof F., Montalban X., Thompson A., Filippi M.Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis. Lancet Neurol2005; 4: 281-288.