Sage Journals: Discover world-class research

Abstract

Fatigue: Take Control is a novel program to teach fatigue management to people with multiple sclerosis (MS) following recommendations in the Fatigue and Multiple Sclerosis guideline. Fatigue: Take Control includes six 2-hour group sessions with DVD viewing, discussion and homework and accompanying participant and leader workbooks. While many people have participated in Fatigue: Take Control programs, its efficacy has not been determined. The objective of this study was to determine whether participation in Fatigue: Take Control reduces fatigue and increases self-efficacy in people with MS. Thirty participants were randomly assigned to a group who immediately participated in the program (FTC) or a wait-list group (WL). The primary outcome was the Modified Fatigue Impact Scale (MFIS) and secondary outcomes were the Multiple Sclerosis Self-Efficacy Scale (MSSE) and the Fatigue Severity Scale (FSS). The MFIS was administered on 10 occasions. Other measures were administered on four occasions. A mixed model tested the effects using all observations. Compared with the WL, the FTC group had significantly more improvement on the MFIS [F(1, 269) = 7.079, p = 0.008] and the MSSE [F(1, 111) = 5.636, p = 0.019]. No significant effect was found for the FSS. Across all visits, fatigue was significantly lower and self-efficacy was significantly higher for the FTC group compared with the WL group. This pilot study demonstrated significant effects in fatigue and self-efficacy among subjects taking the Fatigue: Take Control program, suggesting that this comprehensive program based on the Fatigue and Multiple Sclerosis guideline may be beneficial in MS.

Keywords

energy conservation exercise fatigue guideline multiple sclerosis quality of life rehabilitation self-efficacy symptom management

Get full access to this article

View all access options for this article.

References

Multiple Sclerosis Council for Clinical Practice Guidelines. Fatigue and Multiple Sclerosis: Evidence-based management strategies for fatigue in multiple sclerosis, 1998, Paralyzed Veterans of America, Washington, DC, USA.

Schwid SR , Petrie MD , Murray R. , Leitch J. , Bowen J. , Alquist A. , et al. for the NASA/MS Cooling Study Group. A randomized controlled study of the acute and chronic effects of cooling therapy for MS. Neurology 2003; 60: 1955-1960.

Oken BS , Kishiyama S. , Zajdel D. , Bourdette D. , Carlsen J. , Haas M. , et al. Randomized controlled trial of yoga and exercise in multiple sclerosis. Neurology 2004; 62: 2058-2064.

Petajan JH , Gappmaier E. , White AT , Spencer MK , Mino L. , Hicks RW Impact of aerobic training on fitness and quality of life in multiple sclerosis . Ann Neurol 1996; 39: 432-441.

Mathiowetz V. , Matuska KM , Murphy ME Efficacy of an energy conservation course for persons with multiple sclerosis. Arch Phys Med Rehabil 2001; 82: 449-456.

Mathiowetz VG , Finlayson ML , Matuska KM , Chen HY , Luo P. Randomized controlled trial of an energy conservation course for persons with multiple sclerosis. Mult Scler 2005; 11: 592-601.

Mathiowetz VG , Matuska KM , Finlayson ML , Luo P. , Chen HY One-year follow-up to a randomized controlled trial of an energy conservation course for persons with multiple sclerosis . Int J Rehabil Res 2007; 30: 305-313.

Krupp LB , Coyle PK , Doscher C. , Miller A. , Cross AH , Jandorf L. , et al. Fatigue therapy in multiple sclerosis: results of a double-blind, randomized, parallel trial of amantadine, pemoline, and placebo. Neurology 1995; 45: 1956-1961.

Rammohan KW , Rosenberg JH , Lynn DJ , Blumenfeld AM , Pollak CP , Nagaraja HN Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study. J Neurol Neurosurg Psychiatry 2002; 72: 179-183.

10.

Wingerchuk DM , Benarroch EE , O’Brien PC , Keegan BM , Lucchinetti CF , Noseworthy JH , et al. A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis. Neurology 2005; 64: 1267-1269.

11.

Kos D. , Duportail M. , D’hooghe M. , Nagels G. , Kerckhofs E. Multidisciplinary fatigue management programme in multiple sclerosis: a randomized clinical trial. Mult Scler 2007; 13: 996-1003.

12.

Copperman L. , Hugos C. Fatigue: Take Control. 2003, National Multiple Sclerosis Society, New York, NY, USA.

13.

Bandura A. Self-efficacy: Toward a unifying theory of behavioral change. Psychol Rev 1977; 84: 191-215.

14.

Bandura A. Self-efficacy in changing societies. Cambridge: Cambridge University Press, 1995.

15.

Schwartz CE , Coulthard-Morris L. , Zeng Q. , Retzlaff P. Measuring self-efficacy in people with multiple sclerosis: a validation study. Arch Phys Med Rehabil 1996; 77: 394-398.

16.

National Multiple Sclerosis Society. Fatigue: Take Control pilot chapter results. National Multiple Sclerosis Society, 2005.

17.

Krupp L. , McLinskey N. , MacAllister W. Fatigue in multiple sclerosis. In: Cohen J, Rudick R (eds) Multiple sclerosis Therapeutics. Informa Healthcare, 2007, p. 773.

18.

Tellez N. , Rio J. , Tintore M. , Nos C. , Galan I. , Montalban X.

Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS?

Mult Scler 2005; 11: 198-202.

19.

Polman CH , Reingold SC , Edan G. , Filippi M. , Hartung HP , Kappos L. , et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the ‘McDonald Criteria’. Ann Neurol 2005; 58: 840-846.

20.

Bowen J. , Gibbons L. , Gianas A. , Kraft GH Self-administered Expanded Disability Status Scale with functional system scores correlates well with a physician-administered test. Mult Scler 2001; 7: 201-206.

21.

Beck A. , Steer R. , Brown G. BDI-II Beck Depression Inventory, 2nd Edition. 1996, Harcourt Brace & Company, San Antonio, TX, USA.

22.

Bakshi R. , Shaikh ZA , Miletich RS , Czarnecki D. , Dmochowski J. , Henschel K. , et al. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Mult Scler 2000 ; 6: 181-185.

23.

Flachenecker P. , Kumpfel T. , Kallmann B. , Gottschalk M. , Grauer O. , Rieckmann P. , et al. Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler 2002; 8: 523-526.

24.

Krupp LB , LaRocca NG , Muir-Nash J. , Steinberg AD The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989; 46: 1121-1123.

25.

Fisk JD , Pontefract A. , Ritvo PG , Archibald CJ , Murray TJ The impact of fatigue on patients with multiple sclerosis. Can J Neurol Sci 1994; 21: 9-14.

26.

Fisk JD , Ritvo PG , Ross L. , Haase DA , Marrie TJ , Schlech WF Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis 1994; 18: S79-S83.

27.

Krupp LB , Alvarez LA , LaRocca NG , Scheinberg LC Fatigue in multiple sclerosis. Arch Neurol 1988; 45: 435-437.

Clinical trial of a formal group fatigue program in multiple sclerosis

Abstract

Keywords

Get full access to this article

References