Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
1 Aggarwal S Pittenger MF . Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood2005; 105: 1815–1822.
2.
2 Sotiropoulou PA Perez SA Gritzapis AD Baxevanis CN Papamichail M . Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells2006; 24: 74–85.
3.
3 Mazzanti B Aldinucci A Biagioli T . Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment. J Neuroimmunol2008; 199: 142–150.
4.
4 Lu LL Liu YJ Yang SG . Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica2006; 91: 1017–1026.
5.
5 Le Blanc K Rasmusson I Sundberg B . Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet2004; 363: 1439–1441.
