Defining the natural history of multiple sclerosis: the need for complete data and rigorous definitions. Answer to Dr Tremlett et al.

1 Confavreux C  . Defining the natural history of multiple sclerosis: the need for complete data and rigourous definitions. Mult Scler 2008; 14: 289–291.

2 Kurtzke JF  . On the evaluation of disability in multiple sclerosis. Neurology 1961; 11: 686–694.

3 Kurtzke JF  . Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33: 1444–1452.

4 Confavreux C  Vukusic S  Moreau T  Adeleine P  . Relapses and progression of disability in multiple sclerosis. N Engl J Med 2000; 343: 1430–1438.

5 Confavreux C  Vukusic S  Adeleine P  . Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 2003; 126: 770–782.

6 Confavreux C  Vukusic S  . Age at disability milestones in multiple sclerosis. Brain 2006; 129: 595–605.

7 Confavreux C  Vukusic S  . Natural history of multiple sclerosis: a unifying concept. Brain 2006; 129: 606–616.

8 Confavreux C  Compston A  . The natural history of multiple sclerosis. In: A Compston  , (ed), McAlpine’s multiple sclerosis. 4th ed. London: Churchill Livingstone Elsevier; 2006. p. 183–272.

9 Amato MP  Grimaud J  Achiti I  . For the Evaluation of the EDMUS System (EVALUED) Study Group. European validation of a standardized clinical description of multiple sclerosis. J Neurol 2004; 251: 1472–1480.

10 Tremlett H  Paty D  Devonshire V  . Disability progression in multiple sclerosis is slower than previously reported. Neurology 2006; 66: 172–177.