T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5 T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3 T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = —0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study. Multiple Sclerosis 2007; 13: 880—883. http://msj.sagepub.com
Drayer B., Burger P., Hurwitz B., Dawson D., Cain J.Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content?AJNR1987 ; 8: 413—19.
2.
Bakshi R., Benedict Rhb, Bermel RA, Caruthers SD, Puli SR, Tjoa CW et al. T2 hypointensity in the deep grey matter of patients with multiple sclerosis, A quantitative magnetic resonance imaging study. Arch Neurol2002; 59: 62—68.
3.
Pujol J., Junque C., Vendrell P., Grau JM, Marti-Vilalta JL, Olive C. et al. Biological significance of iron-related magnetic resonance imaging changes in the brain. Arch Neurol1992; 49: 711—17.
4.
Sled JG, Zijdenbos AP, Evans ACA nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging1998; 17: 87—97.
5.
Jenkinson M. , Bannister P., Brady M., Smith S.Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage2002; 17: 825—41.
6.
Schenck JF, Zimmerman EAHigh-field MRI of brain iron: birth of a biomarker?NMR Biomed2004; 17: 433—45.
7.
Fisher E., Rudick RA, Cutter G., Baier M., Miller D., Weinstock-Guttman B. et al. Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients. Mult Scler2000; 6: 373—77. 8. Brass SD, Benedict RHB, Weinstock-Guttman B,
8.
Munschauer F., Bakshi R.Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis. Mult Scler2006; 12: 437—44.
Dwork AJ, Schon EA, Herbert J.Nonidentical distribution of transferring and ferric iron in human brain. Neuroscience1988; 27: 333—45.
11.
Connor JR, Menzies SL, Martin SM, Mufson EJCellular distribution of transferrin, ferritin, and iron in normal and aged human brains. J Neurosci Res1990 ; 27: 595—611.
12.
LeVine SM, Chakrabarty A.The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann NY Acad Sci2004 ; 1012: 252—66.
13.
LeVine SM, Maiti S., Emerson MR, Pedchenko TVApoferritin attenuates experimental allergic encephalomyelitis in SJL mice . Dev Neurosci2002; 24: 177—83.
