We report a case of systemic follicular B-cell lymphoma presenting with widespread skin lesions.
Objective:
The clinical features, histology, and treatment of primary and secondary cutaneous follicular lymphomas are discussed.
Conclusion:
The demonstration of chromosome 14; 18 translocation in the skin that is commonly found in primary, but rare in secondary, cutaneous follicular lymphoma can be helpful in confirming the diagnosis.
Get full access to this article
View all access options for this article.
References
1.
JaafeESShevachEMFranchMM. Nodular lymphoma: Evidence for origin from follicular B lymphocytes. N Engl J Med1974; 290: 813–819.
2.
WarnkeRLevyR. Immunopathology of follicular lymphomas: A model for B-lymphocytes homing. N Engl J Med1978; 298: 481–486.
3.
LevineGDDorfmanRF. Nodular lymphoma. An ultrastructural study of its relationship to germinal centers and a correlation of light and electron microscopic findings. Cancer1975; 35:148–164.
4.
VolkenandtMCerroniLRiegerE. Analysis of the 14; 18 translocation in cutaneous lymphomas using the polymerase chain reaction. J Cutan Pathol1992; 19:353–356.
5.
FukuharaSRowleyJDVariakojisD. Chromosome abnormalities in poorly differentiated lymphocytic lymphoma. Cancer Res1979; 39:3119–3128.
6.
YunisJJFrizzeraGOkenMM. Multiple recurrent genomic defects in follicular lymphoma. N Engl J Med1987; 316:79–84.
7.
WeissLMWarnkeRASklarJ. Molecular analysis of the 14; 18 chromosomal translocation in malignant lymphoma. N Engl J Med1987;317:1185–1189.
8.
HorsmanDEGascoyneRDCouplandRW. Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t(14;18) in follicular lymphoma. Am J Clin Pathol1995; 103:472–478.
9.
DabskiKBanksPMWinkelmannRK. Clinicopathologic spectrum of cutaneous manifestations in systemic follicular lymphoma. Cancer1989; 64:1480–1485.
10.
JonesSEFuksZBullM. Non-Hodgkins lymphomas: IV. clinicopathologic correlation in 405 cases. Cancer1973; 31: 806–823.
WillemzeRMeijerCJLMSentisHJ. Primary cutaneous large cell lymphomas of follicular center cell origin. J Am Acad Dermatol1987; 16:518–523.
13.
GarciaCFWeissLMWarnkeRA. Cutaneous follicular lymphoma. Am J Surg Pathol1986; 10:454–463.
14.
SantucciMPimpinelliNArganiniL. Primary cutaneous B-cell lymphoma: A unique type of low-grade lymphoma: Clinicopathologic and immunologic study of 83 cases. Cancer1991; 67:2311–2326.
15.
RosenbergSABerardCWBrownBW. National Cancer Institute-sponsored study of classifications of non-Hodgkin's lymphomas. Cancer1982; 49:2112–2135.
16.
Van den BergHMMolenaarWMPoppemaS. The heterogeneity of follicular center cell tumors. II. Clinical follow-up of 30 patients. Cancer1983; 52:2264–2268.
17.
HorningSJWeissLMNevittJB. Clinical and pathologic features of follicular large cell lymphoma. Cancer1987; 59:1470–1474.
18.
RappaportRWinterWJHicksEB. Follicular lymphoma. A reevaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer1956; 9:792–821.
19.
RijlaarsdamJUMeijerCJLMWillemzeR. Differentiation between lymphadenosis benigna cutis and primary cutaneous follicular center cell lymphomas. Cancer1990; 65:2301–2306.
20.
NathwaniBNWinbergCDDiamondLW. Morphologic criteria for the differentiation of follicular lymphoma from florid reactive follicular hyperplasia: A study of 80 cases. Cancer1981; 48: 1794–1806.
21.
BurgGKerlHSchmoeckelC. Differentiation between malignant B-cell lymphomas and pseudolymphomas of the skin. J Dermatol Surg Oncol1984; 10:271–275.
22.
TsujimotoYCroceCM. Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA1986; 83:5214–5218.
23.
HockenberyDNunezGMillimanC. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature1990; 343:334–336.
24.
RijlaarsdamJUToonstraJMeijerOWM. Treatment of primary cutaneous B-cell lymphomas of follicle-center-cell origin: A clinical follow-up study of 55 patients treated with radiotherapy or polychemotherapy. J Clin Oncol1996; 14:549–555.
