KraningKKOdlandGF, eds. Prevalence, morbidity, and cost of dermatological diseases. J Invest Dermatol1979; 73(5, pt 11):395–513.
2.
KooJYSmithLL. Psychological aspects of acne. Pediatr Dermatol1991; 8:185–188.
3.
CunliffeW. Acne. London, England: Martin Dunitz, 1989.
4.
MontagnaW. The sebaceous glands in man. In: MontagnaWEllisRASilverAF, eds. Advances in biology of skin: the sebaceous glands, IV. Oxford, England: Pergamon Press, 1963:19–31.
5.
BrandesDBertiniFSmithEW. Role of lysosomes in cellular lytic process. II: Cell death during holocrine secretion in sebaceous glands. Exp Mol Pathol1965: 4:245–265.
6.
NikkariT. Comparative chemistry of sebum. J Invest Dermatol1974; 62:257–267.
7.
ShalitaAR. Genesis of free fatty acids. J Invest Dermatol1974; 62:332–357.
8.
NicolaidesN. Skin lipids: their biochemical uniqueness. Science1974; 186:19–26.
9.
DowningDTStewartMEWenzPWStraussJS. Essential fatty acids and acne. J Am Acad Dermatol1986; 14:221–225.
10.
MorelloAMDowningDTStraussJS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol1976; 66:319–323.
11.
StewartMEWertzPWGrahekMODowningDT. Relationship between sebum secretion rates and the concentration of linoleate in sebum and epidermal lipids (Abstract). Clin Res1985; 33:684A.
12.
StewartMEGreenwoodRCunliffeWJ. Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic acid in various skin surface lipid classes. Arch Dermatol Res1986; 278:481–485.
13.
WertPWMiethkeMCLongSA. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol1985; 84:410–412.
14.
PochiPEStraussJS. Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol1974;62:191–201.
HarrisHHDowningDTStewartMEStraussJS. Sustainable rates of sebum secretion in acne patients and matched normal control subjects. J Am Acad Dermatol1983; 8:200–203.
17.
JarrettA. The effects of progesterone and testosterone on surface sebum and acne vulgaris. Br J Dermatol1969; 71:102–116.
18.
PochiPEStraussJS. Effect of cyclic administration of conjugated equine estrogens on sebum production in women. J Invest Dermatol1966; 47:582–585.
19.
StraussJSPochiPE. The human sebaceous gland: its regulation by steroidal hormones and its use as an end organ for assaying androgenicity in-vivo. Recent Prog Horm Res1963; 19:385–444.
20.
PochiPEStraussJSMesconH. Sebum secretion and urinary fractional 17-ketosteroid and total 17-hydroxycorticoid excretion in male castrates. J Invest Dermatol1962; 39:475–483.
21.
StraussJSKligmanAM. The effect of progesterone and progesterone-like compounds on the human sebaceous gland. J Invest Dermatol1961; 36:309–319.
22.
ZeligmanIHubenerLF. Experimental production of acne by progesterone. Arch Dermatol1957; 76:652–658.
23.
SimpsonNBPowdenPEForsterRACunliffeWJ. The effect of topically applied progesterone on sebum excretion rate. Br J Dermatol1979; 100:687–692.
24.
StraussJSPochiPE. Effect of cyclic progestin-estrogen therapy on sebum and acne in women. JAMA1964; 190:815–819.
25.
PochiPEStraussJS. Effect of sequential mestranol-chlormadinone on sebum production. Arch Dermatol1967; 95:47–49.
26.
PyeRJMeyrickGPyeMJBurtonJL. Effect of oral contraceptives on sebum excretion rate. Br Med J1977; 2:1581–1582.
27.
MillerJAWojnarowskaFTDowdPM. Antiandrogen treatment in women with acne: a controlled trial. Br J Dermatol1986; 114:705–716.
28.
SansoneGReisnerRM. Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin: a possible pathogenic factor in acne. J Invest Dermatol1979; 56:366–372.
29.
LookingbillDPHortonRDemersLM. Tissue production of androgens in women with acne. J Am Acad Dermatol1985; 12:481–487.
30.
PochiPELongcopeC. 5α r-Androstane-3α, 17,B-diol glucuronide blood levels and sebum secretion in acne and normal subjects. In: MarksRPlewigG, eds. Acne and related disorders. London, England: Martin Dunitz, 1989:67–69.
31.
StraussJSKligmanAM. The pathologic dynamics of acne vulgaris. Arch Dermatol1960; 82:779–790.
32.
KnutsonDD. Ultrastructural observations in acne vulgaris: the normal sebaceous follicle and acne lesions. J Invest Dermatol1974; 62:288–307.
33.
WolffHHPlewigGBraun-FalcoO. Ultrastructure of human sebaceous follicles and comedones following treatment with vitamin A acid. Acta Derm Venereol Suppl (Stockh)1975; 55(Suppl 74):99–110.
34.
LavkerRMLeydenJJ. Lamellar inclusions in follicular horny cells: a new aspect of abnormal keratinization. J Ultrastruct Res1979; 69:362–370.
35.
PlewigGFultonJEKligmanAM. Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch1971; 242:12–29.
36.
KurokawaLMayer-da-SilvaAGollnickHOrfanosCF. Occurrence and distribution of cytokeratins and filaggrin in the human pilosebaceous unit: an immunocytochemical study. In: MarksRPlewigG, eds. Acne and related disorders. London, England: Martin Dunitz, 1989:19–22.
37.
KluznikARWoodEJCunliffeWJ. Keratin characterization in the pilosebaceous ducts of acne patients. In: MarksRPlewigG, eds. Acne and related disorders. London, England: Martin Dunitz, 1989:113–115.
38.
KligmanAMKatzAG. Pathogenesis of acne vulgaris: come-dogenic properties of human sebum in external ear canal of the rabbit. Arch Dermatol1968; 98:53–57.
39.
Saint-LegerDBagueACohenEChivotM. A possible role for squalene in the pathogenesis of acne, I: in vitro study of squalene oxidation. Br J Dermatol1986; 114:535–542.
40.
MotoyoshiK. Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxides. Br J Dermatol1983; 109:191–198.
41.
LavkerRMLeydenJJMcGinleyKJ. The relationship between bacteria and the abnormal follicular keratinization in acne vulgaris. J Invest Dermatol1981; 77:325–330.
StraussJSJacksonEM. Academy of Dermatology Invitational Symposium on Comedogenicity. J Am Acad Dermatol1989; 20:272–277.
44.
KaidbeyKHKligmanAM. The pathogenesis of topical steroid acne. J Invest Dermatol1974; 62:31–36.
45.
NorrisJFBCunliffeWJ. A histological and immunocytochemical study of early acne lesions. Br J Dermatol1988; 118:651–659.
46.
LavkerRMLeydenJJKligmanAM. The anti-inflammatory activity of isotretinoin is a major factor in the clearing of acne conglobata. In: MarksRPlewigG, eds. Acne and related disorders. London, England: Martin Dunitz, 1989:207–217.
47.
GilchristTC. The etiology of acne vulgaris. J Cutan Dis Syph1903; 21:107–120.
48.
EvansCASmithWMJohnstonEAGiblettER. Bacterial flora of the normal human skin. J Invest Dermatol1950; 15:305–324.
49.
FreinkelRKStraussJSYipSYPochiPE. Effect of tetracycline on the composition of sebum in acne vulgaris. N Engl J Med1965; 273:8504.
50.
MarplesRRLeydenJJStewartRN. The skin microflora in acne vulgaris. J Invest Dermatol1974; 62:37–41.
51.
MarplesRRKligmanAM. Ecological effects of oral antibiotics on the microflora of human skin. Arch Dermatol1971; 103:148–153.
52.
Ad Hoc Committee on the Use of Antibiotics in Dermatology. Systemic antibiotics for treatment of acne vulgaris: efficacy and safety. Arch Dermatol1975; 111:1630–1636.
53.
MarplesRRDowningDTKligmanAM. Control of free fatty acids in human surface lipids by Corynebacterium acnes. J Invest Dermatol1971; 56:127–131.
54.
StraussJSPochiPE. Intracutaneous injection of sebum and comedones: histological observations. Arch Dermatol1965; 92:443–456.
55.
PuhvelSMSakamotoM. An in vivo evaluation of the inflammatory effect of purified comedonal components in human skin. J Invest Dermatol1977; 69:401–406.
56.
PuhvelSMSakamotoM. The chemoattractant properties of comedonal components. J Invest Dermatol1978; 71:324–329.
57.
WebsterGFLeydenJJ. Characterization of serum-independent polymorphonuclear leukocyte chemotactic factors produced by Propionibacterium acnes. Inflammation1980; 4:261–269.
58.
LeydenJJMcGinleyKJMillsOHJrKligmanAM. Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol1975; 65:3824.
59.
WebsterGFTsaiC-CLeydenJJ. Neutrophil lysosomal release in response to Propionibacterium acnes (Abstract). J Invest Dermatol1979; 72:209.
60.
WebsterGFKligmanAM. A method for the assay of inflammatory mediators in follicular casts. J Invest Dermatol1979; 73:266–268.
61.
WebsterGFLeydenJJNilssonUR. Complement activation in acne vulgaris: consumption of complement by comedones. Infect Immun1979; 26:183–186.
62.
WebsterGFLeydenJJNormanMENilssonUR. Complement activation in acne vulgaris: in vitro studies with Propionibacterium acnes and Propionibacterium granulosum. Infect Immun1978; 22:523–529.
63.
PuhvelSMBarfataniMWarnickMSternbergTH. Study of antibody levels to Corynebacterium acnes. Arch Dermatol1964; 90:421–427.
64.
PuhvelSMHoffmanLKSternbergTH. Presence of complement fixing antibodies to Corynebacterium acnes in the sera of acne patients with acne vulgaris. Arch Dermatol1966; 93:364–366.
65.
DahlMGCMcGibbonDH. Complement in inflammatory acne vulgaris (Letter). BMJ1976; 2:1383.
66.
PuhvelSMAmircanDWeintraubJReisnerRM. Lymphocyte transformation in subjects with nodulo-cystic acne. Br J Dermatol1977;97:205–211.
67.
PuhvelSMHoffmanIKReisnerRMSternbergTH. Dermal hypersensitivity of patients with acne vulgaris to Corynebacterium acnes. J Invest Dermatol1967; 49:154–158.
68.
PuhvelSMReisnerRM. The production of hyaluronidase (hyaluronate lyase) by Corynebacterium acnes. J Invest Dermatol1972; 58:66–70.
69.
VossJG. Differentiation of two groups of Corynebacterium acnes. J Bacteriol1970; 101:392–397.
70.
TuckerSBRogersRSWinkelmannRK. Inflammation in acne vulgaris: leukocyte attraction and cytotoxicity by comedonal material. J Invest Dermatol1980; 74:21–25.
VowelsBRYangSLeydenJJ. Induction of proinflammatory cytokines by a soluble factor of P. acnes; implications for chronic acne. Infect Immun1995; 63:3158–3165.