Sage Journals: Discover world-class research

Abstract

Atopic dermatitis (AD) severity measurement scales are important in clinical trials as objective outcome measures and are often required for government and private insurance plans. These scales are sometimes underused by clinicians due to a variety of factors including time constraints and lack familiarity. We conducted a literature review on the most commonly used AD measurement scales and provide succinct user guides and scoring explanations, advantages and disadvantages, and interscale comparisons.

Keywords

atopic dermatitis eczema SCORAD EASI IGA SASSAD POEM-PO-SCORAD patient reported outcomes

Get full access to this article

View all access options for this article.

References

Tofte

Graeber

Cherill

Omoto

Thurston

Hanifin

. Eczema area and severity index (EASI): a new tool to evaluate atopic dermatitis. Journal of the European Academy of Dermatology and Venereology. 1998;11:S197.doi:10.1016/S0926-9959(98)95291-6

Hanifin

JM.

Thurston

Omoto

et al. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI evaluator group. Exp Dermatol. 2001;10(1):11-18.doi:10.1034/j.1600-0625.2001.100102.x

http://www.ncbi.nlm.nih.gov/pubmed/11168575

Bożek

Reich

. Assessment of intra- and inter-rater reliability of three methods for measuring atopic dermatitis severity: EASI, objective SCORAD, and IgA. Dermatology. 2017;233(1):16-22.doi:10.1159/000472711

http://www.ncbi.nlm.nih.gov/pubmed/28494438

Schmitt

Langan

Williams

Network

ED-E

European Dermato-Epidemiology Network . What are the best outcome measurements for atopic eczema? A systematic review. J Allergy Clin Immunol. 2007;120(6):1389-1398.doi:10.1016/j.jaci.2007.08.011

http://www.ncbi.nlm.nih.gov/pubmed/17910890

Schmitt

Langan

Deckert

et al. Assessment of clinical signs of atopic dermatitis: a systematic review and recommendation. J Allergy Clin Immunol. 2013;132(6):1337-1347.doi:10.1016/j.jaci.2013.07.008

http://www.ncbi.nlm.nih.gov/pubmed/24035157

Charman

CR.

Venn

AJ.

Williams

. The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients’ perspective. Arch Dermatol. 2004;140(12):1513-1519.doi:10.1001/archderm.140.12.1513

http://www.ncbi.nlm.nih.gov/pubmed/15611432

Charman

CR.

Venn

AJ.

Williams

Bigby

. Measuring atopic eczema severity visually: which variables are most important to patients? Arch Dermatol. 2005;141(9):1146-1151.doi:10.1001/archderm.141.9.1146

http://www.ncbi.nlm.nih.gov/pubmed/16172312

Shim

W-H.

Park

H-J.

Kim

H-S

et al. Does the EASI score reflect itch severity? Ann Allergy Asthma Immunol. 2011;106(6):540-541.doi:10.1016/j.anai.2011.02.005

http://www.ncbi.nlm.nih.gov/pubmed/21624757

Barbier

Paul

Luger

et al. Validation of the Eczema Area and Severity Index for atopic dermatitis in a cohort of 1550 patients from the pimecrolimus cream 1% randomized controlled clinical trials programme. Br J Dermatol. 2004;150(1):96-102.doi:10.1111/j.1365-2133.2004.05696.x

http://www.ncbi.nlm.nih.gov/pubmed/14746622

10.

Schram

ME.

Spuls

PI.

Leeflang

MMG.

Lindeboom

Bos

JD.

Schmitt

. EASI, (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference. Allergy. 2012;67(1):99-106.doi:10.1111/j.1398-9995.2011.02719.x

http://www.ncbi.nlm.nih.gov/pubmed/21951293

11.

Chopra

Silverberg

. Assessing the severity of atopic dermatitis in clinical trials and practice. Clin Dermatol. 2018;36(5):606-615.doi:10.1016/j.clindermatol.2018.05.012

http://www.ncbi.nlm.nih.gov/pubmed/30217273

12.

Hill

MK.

Kheirandish Pishkenari

Braunberger

TL.

Armstrong

AW.

Dunnick

. Recent trends in disease severity and quality of life instruments for patients with atopic dermatitis: a systematic review. J Am Acad Dermatol. 2016;75(5):906-917.doi:10.1016/j.jaad.2016.07.002

http://www.ncbi.nlm.nih.gov/pubmed/27615798

13.

Rehal

Armstrong

AW.

Armstrong

. Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010. PLoS One. 2011;6(4):e17520 doi:10.1371/journal.pone.0017520

http://www.ncbi.nlm.nih.gov/pubmed/21533286

14.

Futamura

Leshem

YA.

Thomas

KS.

Nankervis

Williams

HC.

Simpson

. A systematic review of Investigator Global Assessment (IgA) in atopic dermatitis (AD) trials: many options, no standards. J Am Acad Dermatol. 2016;74(2):288-294.doi:10.1016/j.jaad.2015.09.062

http://www.ncbi.nlm.nih.gov/pubmed/26685719

15.

Feldman

SR.

Cox

LS.

Strowd

et al. The challenge of managing atopic dermatitis in the United States. Am Health Drug Benefits. 2019;12(2):83.http://www.ncbi.nlm.nih.gov/pubmed/31057694

16.

Schallreuter

Levenig

Berger

et al. Severity scoring of atopic dermatitis: the SCORAD index. Dermatology. 1993;186(1):23-31.

17.

Berth-Jones

. Six area, six sign atopic dermatitis (SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis. Br J Dermatol. 1996;135(s48):25-30.doi:10.1111/j.1365-2133.1996.tb00706.x

http://www.ncbi.nlm.nih.gov/pubmed/8881901

18.

Yang

HJ.

Jeon

YH.

Pyun

. Evaluation of patient’s subjective severity using various scoring system in Korean children with atopic dermatitis. Asian Pac J Allergy Immunol. 2010;28(2-3):130.http://www.ncbi.nlm.nih.gov/pubmed/21038781

19.

Stalder

J-F.

Barbarot

Wollenberg

et al. Patient-Oriented SCORAD (PO-SCORAD): a new self-assessment scale in atopic dermatitis validated in Europe. Allergy. 2011;66(8):1114-1121.doi:10.1111/j.1398-9995.2011.02577.x

http://www.ncbi.nlm.nih.gov/pubmed/21414011

20.

Boccardi

D’Auria

Turati

et al. Disease severity and quality of life in children with atopic dermatitis: PO-SCORAD in clinical practice. Minerva Pediatr. 2017;69(5):373-380.doi:10.23736/S0026-4946.16.04294-8

http://www.ncbi.nlm.nih.gov/pubmed/26200523

21.

Coutanceau

Stalder

J-F

. Analysis of correlations between patient-oriented SCORAD (PO-SCORAD) and other assessment scores of atopic dermatitis severity and quality of life. Dermatology. 2014;229(3):248-255.doi:10.1159/000365075

http://www.ncbi.nlm.nih.gov/pubmed/25196258

22.

van Oosterhout

Janmohamed

SR.

Spierings

Hiddinga

de Waard-van der Spek

FB.

Oranje

. Correlation between objective SCORAD and Three-Item severity score used by physicians and objective PO-SCORAD used by parents/patients in children with atopic dermatitis. Dermatology. 2015;230(2):105-112.doi:10.1159/000367689

http://www.ncbi.nlm.nih.gov/pubmed/25660989

23.

Mokkink

LB.

Terwee

CB.

Patrick

et al. The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes. J Clin Epidemiol. 2010;63(7):737-745.doi:10.1016/j.jclinepi.2010.02.006

http://www.ncbi.nlm.nih.gov/pubmed/20494804

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.45 MB

0.00 MB

Common Atopic Dermatitis Rating Scales: A Practical Approach and Brief Review

Abstract

Keywords

Get full access to this article

References

Supplementary Material