Darier’s disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier’s disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling familial benign chronic pemphigus or Hailey-Hailey disease.
Objectives:
The objective of this report is to describe an uncommon presentation of Darier’s disease, which has been infrequently described in the literature.
Methods:
The authors present a case of bullous flare of long-standing Darier’s disease.
Conclusions:
Darier’s disease may assume several atypical morphologies, including vesiculo-bullous lesions.
Sherley-DaleACCarrRADharmagunawardenaB. Darier’s disease associated with bullous pemphigoid in a Blaschkoid distribution. Clin Exp Dermatol. 2013;38:672-674.
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SakuntabhaiARuiz-PerezVCarterS. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet. 1999;21:271-277.
