Cutaneous T-cell lymphoma is a rare subtype of posttransplantation lymphoproliferative disease, with only 29 cases reported in the literature to date, the majority of which are post-renal transplantation. Only a few were reported after pancreas, heart, and bone marrow transplantation. There have been no reports of cutaneous T-cell lymphoma following liver transplantation to date.
Objective:
We report a case of a 76-year-old male who developed generalized eczematous eruption 13 years after a liver transplantation. Investigations showed that it was Epstein-Barr virus-negative, CD3-positive, and CD4-positive cutaneous T-cell lymphoma with Sézary cells in the blood.
Conclusion:
This shows that cutaneous T-cell lymphoma/Sézary syndrome can also develop after liver transplantation. To our knowledge, there are no similar reports in the English literature.
Get full access to this article
View all access options for this article.
References
1.
PomerantzRG, CampbellLS, JukicDM. Posttransplant cutaneous T-cell lymphoma: case reports and review of the association of calcineurin inhibitor use with posttransplant lymphoproliferative disease risk. Arch Dermatol2010;146:146-513, doi:10.1001/archdermatol.2010.60.
2.
GottschalkS, RooneyCM, HeslopHE.Post-transplant lymphoproliferative disorders. Annu Rev Med2005;56:56-29, doi:10.1146/annurev.med.56.082103.104727.
3.
RavatFE, SpittleMF, Russell-JonesR.Primary cutaneous T-cell lymphoma occurring after organ transplantation. J Am Acad Dermatol2006;54:668, doi:10.1016/j.jaad.2005.10.015.
4.
LaffitteE, VenetzJP, AubertJD. Mycosis fungoides in a lung transplant recipient with advanced Ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation. Dermatology2008;217:217-87, doi:10.1159/000128283.
5.
Rodriquez-GilY, PalenciaSI, Lopez-RiosF. Mycosis fungoides after solid-organ transplantation: report of 2 new cases. Am J Dermatopathol2008;30:30-150.
6.
CaillardS, LelongC, PessioneF, MoulinB.Post-transplant lymphoproliferative disorders occurring after renal transplantation in adults: report of 230 cases from the French registry. Am J Transplant2006;6:2735, doi:10.1111/j.1600-6143.2006.01540.x.
7.
SmithJM, RudserK, GillenD. Risk of lymphoma after renal transplantation varies with time: an analysis of the United States Renal Data System. Transplantation2006;81:175, doi:10.1097/01.tp.0000188687.18972.a8.
8.
NalesnikMA.Clinicopathologic characteristics of post-transplant lymphoproliferative disorders. Recent Results Cancer Res2002;159:159-9, doi:10.1007/978-3-642-56352-2_2.
9.
ZackheimHS, Kashani-SabetM, HwangST.Low-dose methrotrexate to treat erythrodermic cutanous T-cell lymphoma: results in twenty-nine patients. J Am Acad Dermatol1996;34 4:626–31, doi:10.1016/S0190-9622(96)80062-4.
10.
EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Section IV: long-term management of the transplant recipient. IV.6.1. Cancer risk after renal transplantation. Post-transplant lymphoproliferative disease (PTLD): prevention and treatment. Nephrol Dial Transplant 2002;17 Suppl 4:31–3, 35–6.
11.
SalamaS, ToddS, CinaDP. Cutaneous presentation of postrenal transplant lymphoproliferative disorder: a series of four cases. J Cutan Pathol2010;37:37-641, doi:10.1111/j.1600-0560.2009.01449.x.
12.
NalesnikMA, MakowkaL, StarzlTE.The diagnosis and treatment of posttransplant lymphoproliferative disorders. Curr Probl Surg1988;25:25-367.
13.
PennI.Cancers complicating organ transplantation. N Engl J Med1990;323:323-1767, doi:10.1056/NEJM199012203232510.
14.
SwerdlowSH.Post-transplant lymphoproliferative disorders: a morphologic, phenotypic and genotypic spectrum of disease. Histopathology1992;20:20-373, doi:10.1111/j.1365-2559.1992.tb01007.x.
15.
HantoDW, FrizzeraG, Gajl-PeczalskaKJ. Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation1995;39:39-461.
16.
PennI, BrunsonME.Cancers after cyclosporine therapy. Transplant Proc1988;20(3 Suppl 3):885-92.
LippmanSM, GroganTM, CarryP. Post-transplantation T cell lymphoblastic lymphoma. Am J Med1987;82:82-814, doi:10.1016/0002-9343(87)90020-9.
19.
UlrichW, ChottA, WatschingerB. Primary peripheral T cell lymphoma in a kidney transplant under immunosuppression with cyclosporine A. Hum Pathol1989;20:20-1027, doi:10.1016/0046-8177(89)90277-3.
20.
HansonMN, MorrisonVA, PetersonBA. Posttransplant T-cell lymphoproliferative disorders—an aggressive, late complication of solid-organ transplantation. Blood1996;88:88-3626.
21.
ZutterMM, MartinPJ, SaleGE. Epstein-Barr virus lymphoproliferation after bone marrow transplantation. Blood1988;72:72-520.
22.
LeblondV, SuttonL, DorentR. Lymphoproliferative disorders after organ transplantation: a report of 24 cases observed in a single center. J Clin Oncol1995;13:13-961.
23.
KemnitzJ, CremerJ, GebelM. T-cell lymphoma after heart transplantation. Am J Clin Pathol1990;94:94-95.
24.
WillemzeR, JaffeES, BurgG. WHO-EORTC classification for cutaneous lymphomas. Blood2005;105:105-3768, doi:10.1182/blood-2004-09-3502.
25.
OlsenE, VonderheidE, PimpinelliN. Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal o the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood2007;110:110-1713, doi:10.1182/blood-2007-03-055749.
26.
AlajlanA, AlfadleyA, PdersenKT. Transfer of vitiligo after allogeneic bone marrow transplantation. J Am Acad Dermatol2002;46:46-606, doi:10.1067/mjd.2002.117215.
27.
RallisE, EconomidiA, VerrosC. Successful treatment of patch type mycosis fungoides with tacrolimus ointment 0.1%. J Drugs Dermatol2006;5:5-906.
