Epidermolysis Bullosa Acquisita Responsive to Dapsone Therapy

Abstract

Background:

Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is frequently resistant to therapy.

Objective:

A 58-year-old man who had a one-year history of a bullous eruption involving the hands, forearms, trunk, scalp, and oral mucosa. Histopathology revealed a subepidermal bulla, and direct and indirect immunofluorescence studies were consistent with EBA. The patient failed respond to niacinamide and tetracycline and oral prednisone 40 mg per day.

Methods:

Complete control of his blistering was achieved within two months of initiating oral dapsone, 150 mg per day.

Conclusion:

Dapsone may be an effective agent for some patients with EBA.