Intravitreal faricimab treatment for traumatic choroidal rupture and macular neovascularization in angioid streaks: A case report

Abstract

Introduction

Angioid streaks is a rare retinal condition with pathological fissures in Bruch's membrane due to an abnormal and calcified Bruch's membrane. The condition can occur idiopathic or in association to other conditions. Development of macular neovascularization (MNV) in these angioid streaks, and MNV-related exudation, development of atrophy or in rare cases traumatic rupture can lead to visual symptoms.

Case description

This report describes a case of angioid streaks which was diagnosed after a blunt trauma that lead to visual symptoms and further examination revealed MNV with traumatic rupture. Anti-vascular endothelial growth factor treatment using faricimab was commenced with three injections at four weeks intervals. Family history raised suspicion of a systemic disease, and genetic work-up led to a diagnosis of pseudoxanthoma elasticum. The MNV treated with faricimab led to excellent visual results and no exudative recurrence during a follow-up period of 8 months after the last injection.

Conclusion

This case report presents a clinical approach for managing MNV with traumatic rupture secondary to angioid streaks and is also the first case to present results of faricimab use for these lesions.