Comparison of posterior capsule opacification between Clareon CNA0T0 and Tecnis ZCB00 intraocular lenses

Abstract

Introduction:

The purpose is to compare posterior capsule opacification (PCO) and its impact on vision between Clareon CNA0T0 (Alcon) and Tecnis ZCB00 intraocular lenses (IOLs) (Johnson&Johnson) 1, 6, and 12 months after implantation.

Methods:

A prospective observational study was performed at the Nuestra Señora de Gracia Hospital (Zaragoza, Spain). Fifty eyes (50 patients) with Tecnis IOL (group 1) and 60 eyes (60 patients) with Clareon IOL (group 2) were enrolled. One, 6, and 12 months after age-related cataract surgery by five different surgeons, the following tests were performed: mesopic corrected distance visual acuity (CDVA), CSV1000-E test, KR-1W wavefront analyzer, OQAS II, Catquest-9SF questionnaire and mydriatic slit-lamp pictures. PCO intensity was quantified and the area of opacification was measured using ImageJ (NIH).

Results:

Mean age was 71.20 ± 6.79 years in group 1, and 71.73 ± 8.17 years in group 2 (p = 0.72); mean axial length was 23.46 ± 1.14 and 23.53 ± 0.91 mm, respectively (p = 0.72); mean IOL power was 21.69 ± 2.26 D and 21.28 ± 2.44 D, respectively (p = 0.37). One month after surgery there were differences in intensity of PCO (0.73 ± 0.60 and 1.05 ± 0.71, respectively, p = 0.02). Six months after surgery statistical differences were found in VA with 20% CS in mydriatic conditions (0.26 ± 0.21 logMAR (20/36) and 0.18 ± 0.17 logMAR (20/30), respectively, p = 0.04). Twelve months after surgery, no differences were detected between groups. As for the evolution of PCO within the Clareon group, high order aberrations (p < 0.05) and the Strehl ratio (p = 0.02) decreased.

Conclusion:

There are no differences in slit-lamp pictures or visual function between both IOLs during the first 12 months after implantation.

Keywords

Tecnis ZCB00 Clareon CNA0T0 posterior capsule opacification

Get full access to this article

View all access options for this article.

References

De Giacinto

Porrelli

Turco

, et al. Surface properties of commercially available hydrophobic acrylic intraocular lenses: comparative study. J Cataract Refract Surg 2019; 45(9): 1330–1334.

Cheng

Wei

Cai

, et al. Efficacy of different intraocular lens materials and optic edge designs in preventing posterior capsular opacification: a meta-analysis. Am J Ophthalmol 2007; 143(3): 428–436.

Lloyd

Faragher

RGA

Denyer

. Ocular biomaterials and implants. Biomaterials 2001; 22(8): 769–785.

Han

Yuan

, et al. Effect of anterior capsule polish on visual function: a meta-analysis. PLoS One 2019; 14(1): 1–12.

Hillenmayer

Wertheimer

Kassumeh

, et al. Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model. BMC Ophthalmol 2020; 20(1): 1–7.

Wormstone

Wang

Liu

CSC

. Posterior capsule opacification. Exp Eye Res 2009; 88(2): 257–269.

Tognetto

Toto

Sanguinetti

, et al. Lens epithelial cell reaction after implantation of different intraocular lens materials: two-year results of a randomized prospective trial. Ophthalmology 2003; 110(10): 1935–1941.

Wormstone

. Posterior capsule opacification: a cell biological perspective. Exp Eye Res 2002; 74(3): 337–347.

Tong

Pan

, et al. Retrospective analyses of potential risk factors for posterior capsule opacification after cataract surgery. J Ophthalmol. Epub ahead of print 5 August 2018. DOI: 10.1155/2018/9089285.

10.

Werner

Thatthamla

Ong

, et al. Evaluation of clarity characteristics in a new hydrophobic acrylic IOL in comparison to commercially available IOLs. J Cataract Refract Surg 2019; 45(10): 1490–1497.

11.

Maxwell

Suryakumar

. Long-term effectiveness and safety of a three-piece acrylic hydrophobic intraocular lens modified with hydroxyethyl-methacrylate: an open-label, 3-year follow-up study. Clin Ophthalmol 2018; 12: 2031–2037.

12.

Linnola

Sund

Ylönen

, et al. Adhesion of soluble fibronectin, vitronectin, and collagen type IV to intraocular lens materials. J Cataract Refract Surg 2003; 29(1): 146–152.

13.

Von Tress

Marotta

Lane

, et al. A meta-analysis of Nd: YAG capsulotomy rates for two hydrophobic intraocular lens materials. Clin Ophthalmol 2018; 12: 1125–1136.

14.

Wahba

Riad

Morkos

, et al. Visual performance of the Tecnis one-piece lens ZCB00. Clin Ophthalmol 2011; 5(1): 1803–1808.

15.

Saika

. Relationship between posterior capsule opacification and intraocular lens biocompatibility. Prog Retin Eye Res 2004; 23(3): 283–305.

16.

Nishi

Osakabe

. Effect of intraocular lenses on preventing posterior capsule opacification: design versus material. J Cataract Refract Surg 2004; 30(10): 2170–2176.

17.

Nishi

Wickström

. Preventing lens epithelial cell migration using intraocular lenses with sharp rectangular edges. J Cataract Refract Surg 2000; 26(10): 1543–1549.

18.

Buehl

Findl

. Effect of intraocular lens design on posterior capsule opacification. J Cataract Refract Surg 2008; 34(11): 1976–1985.

19.

Mukherjee

Chaudhury

Das

, et al. Posterior capsular opacification and intraocular lens surface micro-roughness characteristics: an atomic force microscopy study. Micron 2012; 43(9): 937–947.

20.

Tanaka

Shigeta

Yamakawa

, et al. Cell adhesion to acrylic intraocular lens associated with lens surface properties. J Cataract Refract Surg 2005; 31(8): 1648–1651.

21.

Wang

Lin

Shen

, et al. Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to improve the cytocompatibility. J Colloid Interface Sci 2014; 431: 1–7.

22.

Oshika

Fujita

Inamura

, et al. Mid- and long-term clinical assessment of a new single-piece hydrophobic acrylic intraocular lens with hydroxyethyl-methacrylate. J Cataract Refract Surg. Epub ahead of print 27 January 2020. DOI: 10.1097/j.jcrs.0000000000000142.