Primitive neuroectodermal tumors arise from the progenitor cells of the neural crest, in the central nervous system or other peripheral locations.
Case presentation:
We report a rare case of a congenital malignant tumor, diagnosed as a primary orbital primitive neuroectodermal tumor on histopathological examination.
Conclusion:
Multidisciplinary management with adjuvant chemotherapy needed for the management of these cases.
BolenJWThorningD.Peripheral neuroepithelioma: a light and electron microscopic study. Cancer1980; 46: 2456–2462.
2.
DehnerLP.Primitive neuroectodermal tumor and Ewing’s sarcoma. Am J Surg Pathol1993; 17: 1–13.
3.
ShahNRoychoudhuryASarkarC.Primitive neuroectodermal tumor of maxilla in an adult. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol1995; 80: 683–686.
4.
LiYChenLZhouX, et al. A case report of neonatal orbital peripheral primitive neuroectodermal tumor and literature review. Eur J Ophthalmol. Epub ahead of print 2020. DOI: 10.1177/1120672120926937.
5.
TamerCOksuzHHakverdiS, et al. Primary peripheral primitive neuroectodermal tumour of the orbit. Can J Ophthalmol2007; 42: 138–140.
6.
DasDKuriGCDekaP, et al. Primary primitive neuroectodermal tumor of the orbit. Indian J Ophthalmol2009;57: 391.
7.
de AlavaEGeraldWL. Molecular biology of the Ewing’s sarcoma/primitive neuroectodermal tumor family. J Clin Oncol2000; 18: 204–204.
8.
SinghADHussonMShieldsCL, et al. Primitive neuroectodermal tumor of the orbit. Arch Ophthalmol1994; 112: 217–221.
9.
SharmaSKamalaRNairD, et al. Round cell tumors: classification and immunohistochemistry. Indian J Med Paediatr Oncol2017; 38: 349.
10.
ChokthaweesakWAnnunziataCCAlsheikhO, et al. Primitive neuroectodermal tumor of the orbit in adults: a case series. Ophthalmic Plast Reconstr Surg2011; 27: 173–179.
11.
SmorenburgCVan GroeningenCMeijerO, et al. Ewing’s sarcoma and primitive neuroectodermal tumour in adults: single-centre experience in The Netherlands. Neth J Med2007; 65: 132–136.
HuertaÁSPérez-FidalgoJAUrtasunA, et al. High risk Ewing’s sarcomas. Effectiveness and toxicity of a regimen designed for children and used in adults. Revista de Oncología2004; 6: 165–169.
