High myopia is of worldwide concern due to its high prevalence, and myopia is an independent risk factor for glaucoma. The purpose of this paper is to review the mechanism and clinical manifestations of optic disc tilt and rotation in high myopia and its relationship with glaucoma, to provide clues for monitoring fundus changes in high myopia and the early diagnosis of high myopia with glaucoma.
DongLKangYKLiY, et al.Prevalence and time trends of myopia in children and adolescents in China: a systemic review and meta-analysis. Retina2020; 40: 399–411.
2.
MatsumuraSKuoANSawSM. An update of eye shape and myopia. Eye Contact Lens2019; 45: 279–285.
3.
AdamsDLEconomidesJRHortonJC. Cortical representation of a myopic peripapillary crescent. Ophthalmology2016; 123: 1494–1499.
4.
Marsh-TootleWLHarbEHouW, et al.Optic nerve tilt, crescent, ovality, and torsion in a multi-ethnic cohort of young adults With and without myopia. Invest Ophthalmol Vis Sci2017; 58: 3158–3171.
5.
SungMSKangYSHeoH, et al.Characteristics of optic disc rotation in myopic eyes. Ophthalmology2016; 123: 400–407.
6.
KimTWKimMWeinrebRN, et al.Optic disc change with incipient myopia of childhood. Ophthalmology2012; 119: 21–26.
7.
LiZGuoXXiaoO, et al.Optic disc features in highly myopic eyes: the ZOC-BHVI high myopia cohort study. Optom Vis Sci2018; 95: 318–322.
8.
ZhuXHeWZhangK, et al.Fixation characteristics in highly myopic eyes: the shanghai high myopia study. Sci Rep2019; 9: 6502.
9.
SamarawickramaCMitchellPTongL, et al.Myopia-related optic disc and retinal changes in adolescent children from Singapore. Ophthalmology2011; 118: 2050–2057.
10.
Moghadas SharifNShoeibiNEhsaeiA, et al.Optical coherence tomography and biometry in high myopia with tilted disc. Optom Vis Sci2016; 93: 1380–1386.
11.
SungMSKangYSHeoH, et al.Optic disc rotation as a clue for predicting visual field progression in myopic normal-tension glaucoma. Ophthalmology2016; 123: 1484–1493.
12.
VongphanitJMitchellPWangJJ. Population prevalence of tilted optic disks and the relationship of this sign to refractive error. Am J Ophthalmol2002; 133: 679–685.
13.
TayESeahSKChanSP, et al.Optic disk ovality as an index of tilt and its relationship to myopia and perimetry. Am J Ophthalmol2005; 139: 247–252.
14.
ZhaoXJiangHLiY, et al.Correlations between the optic nerve head morphology and ocular biometrics in highly myopic eyes. Int J Ophthalmol2018; 11: 997–1001.
15.
ChenQHeJYinY, et al.Impact of the morphologic characteristics of optic disc on choroidal thickness in young myopic patients. Invest Ophthalmol Vis Sci2019; 60: 2958–2967.
16.
YoonJYSungKRYunSC, et al.Progressive optic disc tilt in young myopic glaucomatous eyes. Korean J Ophthalmol2019; 33: 520–527.
17.
ParkHLKimYCJungY, et al.Vertical disc tilt and features of the optic nerve head anatomy are related to visual field defect in myopic eyes. Sci Rep2019; 9: 3485.
18.
ChoiJHHanJCKeeC. The effects of optic nerve head tilt on visual field defects in myopic normal tension glaucoma: the intereye comparison study. J Glaucoma2019; 28: 341–346.
19.
HosseiniHNassiriNAzarbodP, et al.Measurement of the optic disc vertical tilt angle with spectral-domain optical coherence tomography and influencing factors. Am J Ophthalmol2013; 156: 737–744.
20.
ParkHLChoiSIChoiJ, et al.Disc torsion and vertical disc tilt Are related to subfoveal scleral thickness in open-angle glaucoma patients With myopia. Invest Ophthalmol Vis Sci2015; 56: 4927–4935.
21.
QiuKWangGLuX, et al.Application of the ISNT rules on retinal nerve fibre layer thickness and neuroretinal rim area in healthy myopic eyes. Acta Ophthalmol2018; 96: 161–167.
22.
TakasakiHHigashideTTakedaH, et al.Relationship between optic disc ovality and horizontal disc tilt in normal young subjects. Jpn J Ophthalmol2013; 57: 34–40.
23.
GuoXChenXLiM, et al.Association between morphological characteristics of the optic disc and other anatomical features of the fundus in highly myopic eyes. Eur J Ophthalmol2020; 30: 1120672120945901.
24.
KimEParkHParkCK. Posterior scleral deformations around optic disc are associated with visual field damage in open-angle glaucoma patients with myopia. PLoS One2019; 14: e0213714.
25.
JeonSJLopilly ParkHYChan KimY, et al.Association of scleral deformation around the optic nerve head with central visual function in normal tension glaucoma and myopia. Am J Ophthalmol2020; 217: 287–296.
26.
LeeKSLeeJRKookMS. Optic disc torsion presenting as unilateral glaucomatous-appearing visual field defect in young myopic Korean eyes. Ophthalmology2014; 121: 1013–1019.
27.
NakanishiHTsujikawaAGotohN, et al.Macular complications on the border of an inferior staphyloma associated with tilted disc syndrome. Retina (Philadelphia, Pa.)2008; 28: 1493–1501.
28.
CohenSYQuentelGGuiberteauB, et al.Macular serous retinal detachment caused by subretinal leakage in tilted disc syndrome. Ophthalmology1998; 105: 1831–1834.
29.
FenDJunLJianboX, et al.Optic disc and refractive status in patients with tilted disc syndrome. J Clin Ophthalmol2019; 27: 328–330.
30.
GuohongTMinWXinghuaiS. Clinical features of congenital optic disc anomalies and differential diagnosis. Chin J Ophthalmol Otorhinolaryngol2014; 14: 358–362.
31.
DorrellD. The tilted disc. Br J Ophthalmol1978; 62: 16–20.
32.
Ohno-MatsuiK. Proposed classification of posterior staphylomas based on analyses of Eye shape by three-dimensional magnetic resonance imaging and wide-field Fundus imaging. Ophthalmology2014; 121: 1798–1809.
33.
Ohno-MatsuiKShimadaNNagaokaN, et al.Choroidal folds radiating from the edge of an Inferior staphyloma in an Eye with tilted disc syndrome. Jpn J Ophthalmol2011; 55: 171–173.
34.
IchiroMTomohiroIYukinoriS, et al.Morphologic choroidal and scleral changes at the Macula in tilted disc syndrome with staphyloma using optical coherence tomography. Invest Ophthalmol Vis2011; 52: 8763–8768.
ParkHYLLeeKILeeK, et al.Torsion of the optic nerve head is a prominent feature of normal-tension glaucoma. Invest Ophthalmol Vis Sci2015; 56: 156–163.
39.
LeeKMKimMKimSH. Case report: what gives the myopic tilted disc an oval appearance?BMC Ophthalmol2020; 20: 20.
40.
AlnawaisehMLahmeLMüllerV, et al.Correlation of flow density, as measured using optical coherence tomography angiography, with structural and functional parameters in glaucoma patients. Graefes Arch Clin Exp Ophthalmol2018; 256: 589–597.
41.
Van MelkebekeLBarbosa-BredaJHuygensM, et al.Optical coherence tomography angiography in glaucoma: a review. Ophthalmic Res2018; 60: 139–151.
42.
TanACSTanGSDennistonAK, et al.An overview of the clinical applications of optical coherence tomography angiography. Eye2018; 32: 262–286.
SoomroTTalksJ. The use of optical coherence tomography angiography for detecting choroidal neovascularization, compared to standard multimodal imaging. Eye2018; 32: 661–672.
45.
SungMSLeeTHHeoH, et al.Association between optic nerve head deformation and retinal microvasculature in high myopia. Am J Ophthalmol2018; 188: 81–90.
46.
HayashiKOhno-MatsuiKShimadaN, et al.Long-term pattern of progression of myopic maculopathy: a natural history study. Ophthalmology2010; 117: 1595–1611. 1611.e1591-1594.
47.
HeJChenQYinY, et al.Association between retinal microvasculature and optic disc alterations in high myopia. Eye2019; 33: 1494–1503.
48.
ZhouXZhangSZhangG, et al.Increased choroidal blood perfusion Can inhibit form deprivation myopia in Guinea pigs. Invest Ophthalmol Vis Sci2020; 61: 25.
49.
Zhang S, Zhang G, Zhou X, et al. Changes in choroidal thickness and choroidal blood perfusion in Guinea Pig myopia. Invest Ophthalmol Vis Sci2019; 60: 3074–3083.
50.
Ohno-MatsuiKShimadaNYasuzumiK, et al.Long-term development of significant visual field defects in highly myopic eyes. Am J Ophthalmol2011; 152: 256–265.
51.
ZejmoMFormińska-KapuścikMPieczaraE, et al.Etiopathogenesis and management of high-degree myopia. Part I. Med Sci Monit2009; 15: Ra199–Ra202.
52.
MoschosMMTriglianosARotsosT, et al.Tilted disc syndrome: an OCT and mfERG study. Doc Ophthalmol2009; 119: 23–28.
GürlüVPAlimgilMLBenianO. Topographical analysis of the visual field in tilted disk syndrome. Retina2002; 22: 366–368.
55.
ShoeibiNMoghadas SharifNDaneshvarR, et al.Visual field assessment in high myopia with and without tilted optic disc. Clin Exp Optom2017; 100: 690–694.
56.
HungCHLeeSHLinSY, et al.The relationship between optic nerve head deformation and visual field defects in myopic eyes with primary open-angle glaucoma. PLoS One2018; 13: e0209755.
57.
HanJCLeeEJKimSH, et al.Visual field progression pattern associated With optic disc tilt morphology in myopic open-angle glaucoma. Am J Ophthalmol2016; 169: 33–45.
58.
McCannPHoggRWrightDM, et al.Glaucoma in the northern Ireland cohort for the longitudinal study of ageing (NICOLA): cohort profile, prevalence, awareness and associations. Br J Ophthalmol2020; 104: 1492–1499.
59.
ChiamNBaskaranMLiZ, et al.Social, health and ocular factors associated with primary open angle glaucoma amongst Chinese Singaporeans. Clin Experiment Ophthalmol2018; 46: 25–34.
60.
PanCYangWHuD, et al.Longitudinal cohort study on the incidence of primary open-angle glaucoma in Bai Chinese. Am J Ophthalmol2017; 176: 127–133.
61.
KimMJKimMJKimHS, et al.Risk factors for open-angle glaucoma with normal baseline intraocular pressure in a young population: the Korea National Health and Nutrition Examination Survey. Clin Exp Ophthalmol2014; 42: 825–832.
62.
BaraćJBiukDMatićS, et al.Prevalence of open angle glaucoma in risk groups in Slavonia and Baranya region. Acta Clin Croat2017; 56: 789–794.
63.
ShimSHSungKRKimJM, et al.The prevalence of open-angle glaucoma by Age in myopia: the Korea National Health and Nutrition Examination Survey. Curr Eye Res2016; 42: 65–71.
64.
ZanklonyYAEMEElfatahOMASalemOAEK, et al.Prevalence of glaucoma among high myopia. Egypt J Hosp Med.2018; 72: 4154–4164.
65.
SungMSHeoHJiYS, et al.Predicting the risk of parafoveal scotoma in myopic normal tension glaucoma: role of optic disc tilt and rotation. Eye2017; 31: 1051–1059.
66.
LiuSHongJLuX, et al.Joint optic disc and cup segmentation using semi-supervised conditional GANs. Comput Biol Med2019; 115: 103485.
67.
KyariFAbdullMMWormaldR, et al.Risk factors for open-angle glaucoma in Nigeria: results from the Nigeria national blindness and visual impairment survey. BMC Ophthalmol2016; 16: 78.
68.
JonasJBGusekGCNaumannGO. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci1988; 29: 1151–1158.
69.
JonasJBBuddeWMLangP. Neuroretinal rim width ratios in morphological glaucoma diagnosis. Br J Ophthalmol1998; 82: 1366–1371.
70.
MikiAIkunoYWeinrebRN, et al.En face optical coherence tomography imaging of Beta and gamma parapapillary atrophy in high myopia. Ophthalmol Glaucoma2019; 2: 55–62.
71.
ParkHJungYParkCK. Posterior staphyloma is related to optic disc morphology and the location of visual field defect in normal tension glaucoma patients with myopia. Eye2015; 29: 333–341.
72.
KimYCChoBJJungKI, et al.Comparison of diagnostic power of optic nerve head and posterior sclera configuration parameters on myopic normal tension glaucoma. J Glaucoma2019; 28: 834–842.
73.
ZhuXHeWDuY, et al.Interocular symmetry of fixation, optic disc, and corneal astigmatism in bilateral high myopia: the shanghai high myopia study. Transl Vis Sci Technol2019; 8: 22.
74.
JagadeeshDPhilipKFedtkeC, et al.Posterior segment conditions associated with myopia and high myopia. Clin Exp Optom2020; 103: 756–765.
75.
LeeKMParkSWKimM, et al.Relationship between three-dimensional magnetic resonance imaging eyeball shape and optic nerve head morphology. Ophthalmology2021; 128: 532–544.
76.
ZhouJTuYChenQ, et al.Quantitative analysis with volume rendering of pathological myopic eyes by high-resolution three-dimensional magnetic resonance imaging. Medicine (Baltimore)2020; 99: e22685.