The main goal of this research was to determine the differences between the values of intraocular pressure (IOP) in the supine and sitting positions, and to assess the effect of age and cardiovascular parameters.
Methods:
Seventy-two healthy adults were enrolled and classified into age groups: 20–30 years (group A), 31–40 years (group B), and 41–71 years (group C). Corneal biometry and cardiovascular parameters, such as heart rate (HR), were measured. IOP measurements were taken in the sitting position (IOPS) and in the supine position (IOPL) using the iCare® Pro tonometer.
Results:
A significant difference between the IOPS and IOPL in the entire cohort was found (p < 0.001). Regarding the age subgroups, a significant difference (p < 0.001) between the IOPS and IOPL was obtained in group A (2.6 ± 1.6 mmHg) and group C (1.5 ± 1.3 mmHg). There were no significant differences in the IOPS between groups. The highest IOP values were obtained for group A. The correlations between HR and IOPS are statistically significant for group A and group B, and for HR and IOPL-S for group B only. Multivariate analysis showed that HR has a significant influence on the difference in IOP in the two body positions.
Conclusion:
A statistically significant difference between the effect of age and the values of IOPS and IOPL was shown. Cardiovascular parameters showed some relevant statistical dependencies, but with a rather marginal significance in young people. The influence of body position for the measurement of IOP for healthy subjects does not seem to matter, despite the fact that there are some dependencies that are statistically significant.
BulpittCJHodesCEverittMG.Intraocular pressure and systemic blood pressure in the elderly. Br J Ophthalmol1975; 59: 717–720.
2.
McLeodSDWestSKQuigleyHA, et al. A longitudinal study of the relationship between intraocular and blood pressures. Invest Ophth Vis Sci1990; 31: 2361–2366.
3.
KleinBEKKleinRKnudtsonMD.Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study. Br J Ophthalmol2005; 89: 284–287.
4.
WuSYLeskeMC.Associations with intraocular pressure in the Barbados Eye Study. Arch Ophthalmol1997; 115: 1572–1576.
5.
MemarzadehFYing-LaiMChungJ, et al. Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study. Invest Ophthalmol Vis Sci2010; 51: 2872–2877.
6.
KleinBEKleinR.Intraocular pressure and cardiovascular risk variables. Arch Ophthalmol1981; 99: 837–839.
7.
KleinBEKleinRLintonKL.Intraocular pressure in an American community. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci1992; 33: 2224–2228.
8.
HillerRSperdutoRDKruegerDE.Race, iris pigmentation, and intraocular pressure. Am J Epidemiol1982; 115: 674–683.
9.
JeelaniMTaklikarRHTaklikarA, et al. Variation of intraocular pressure with age and gender. Natl J Physiol Pharm Pharmacol2014; 4: 57–60.
10.
ShioseYKawaseY.A new approach to stratified normal intraocular pressure in a general population. Am J Ophthalmol1986; 101: 714–721.
11.
NomuraHShimokataHAndoF, et al. Age-related changes in intraocular pressure in a large Japanese population: a cross-sectional and longitudinal study. Ophthalmology1999; 106: 2016–2022.
12.
NomuraHAndoFNiinoN, et al. The relationship between age and intraocular pressure in a Japanese population: the influence of central corneal thickness. Curr Eye Res2002; 24: 81–85.
13.
MoriKAndoFNomuraH, et al. Relationship between intraocular pressure and obesity in Japan. Int J Epidemiol2000; 29: 661–666.
14.
NakanoTTatemichiMMiuraY, et al. Long-term physiologic changes of intraocular pressure: a 10-year longitudinal analysis in young and middle-aged Japanese men. Ophthalmology2005; 112: 609–616.
15.
WongTTWongTYFosterPJ, et al. The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an Asian population. Invest Ophthalmol Vis Sci2009; 50: 4097–4102.
16.
QureshiIA.Age and intraocular pressure: how are they correlated?J Pak Med Assoc1995; 45: 150–152.
17.
LinderBJTrickGLWolfML.Altering body position affects intraocular pressure and visual function. Invest Ophthalmol Vis Sci1988; 29: 1492–1497.
18.
YeonDYYooCLeeTE, et al. Effects of head elevation on intraocular pressure in healthy subjects: raising bed head vs using multiple pillows. Eye (Lond)2014; 28: 1328–1333.
19.
BuysYMAlasbaliTJinYP, et al. Effect of sleeping in a head-up position on intraocular pressure in patients with glaucoma. Ophthalmology2010; 117: 1348–1351.
20.
MalihiMSitAJ.Effect of head and body position on intraocular pressure. Ophthalmology2012; 119: 987–991.
21.
OzcanMSPraetelCBhattiMT, et al. The effect of body inclination during prone positioning on intraocular pressure in awake volunteers: a comparison of two operating tables. Anesth Analg2004; 99: 1152–1158.
22.
LandahlSBengtssonCSigurdssonJA, et al. Age-related changes in blood pressure. Hypertension1986; 8: 1044–1049.
HajjarIMGrimCEGeorgeV, et al. Impact of diet on blood pressure and age-related changes in blood pressure in the US population. Arch Intern Med2001; 161: 589–593.
25.
TeréntABreig-AsbergE.Epidemiological perspective of body position and arm level in blood pressure measurement. Blood Press1994; 3: 156–163.
26.
EşerIKhorshidLGüneşUY, et al. The effect of different body positions on blood pressure. J Clin Nurs2007; 16: 137–140.
27.
NeteaRTLendersJWSmitsP, et al. Both body and arm position significantly influence blood pressure measurement. J Hum Hypertens2003; 17: 459–462.
28.
NeteaRTSmitsPLJacquesWM, et al. Does it matter whether blood pressure measurements are taken with subjects sitting or supine?J Hypertens1998; 16: 263–268.
29.
KaskelDMüller-BreitenkampRWilmansI, et al. The influence of changes in body position on intraocular pressure, episcleral venous pressure, and blood pressure. Albrecht Von Graefes Arch Klin Exp Ophthalmol1978; 208: 217–228.
30.
LeeJYYooCJungJH, et al. The effect of lateral decubitus position on intraocular pressure in healthy young subjects. Acta Ophthalmol2012; 90: e68–e72.
31.
CarlsonKHMcLarenJWTopperJE, et al. Effect of body position on intraocular pressure and aqueous flow. Invest Ophthalmol Vis Sci1987; 28: 1346–1352.
32.
JasienJVRitchR.Practical tips: avoiding inversions–intraocular pressure changes and common yoga poses. Glaucoma Now2015; 1: 10–11.
33.
LamAWuY-FWongL-Y, et al. IOP variations from sitting to supine postures determined by rebound tonometer. J Optom2013; 6: 95–100.
34.
MayaliHTekinBKayıkçıoğluOR, et al. Evaluation of the effect of body position on intraocular pressure measured with rebound tonometer. Taiwan J Ophthalmol2019; 49: 6–9.
35.
NajmanováEPluháčekFHaklováM.Intraocular pressure response affected by changing of sitting and supine positions. Acta Ophthalmol2020; 98: e368–e372.
36.
MansouriKWeinrebRNLiuJHK. Effects of aging on 24-hour intraocular pressure measurements in sitting and supine body positions. Invest Ophthalmol Vis Sci2012; 53: 112–126.
37.
VeraJRedondoBMolinaR, et al. Acute intraocular pressure responses to reading: the influence of body position. J Glaucoma2020; 29: 581–586.
38.
FribergTRSanbornGWeinrebRN.Intraocular and episcleral venous pressure increase during inverted posture. Am J Ophthalmol1987; 103: 523-526.
39.
LongoAGeiserMHRivaCE.Posture changes and subfoveal choroidal blood flow. Invest Ophthalmol Vis Sci2004; 45: 546–551.
40.
LazzaroECMallickASinghM, et al. The effect of positional changes on intraocular pressure during sleep in patients with and without glaucoma. J Glaucoma2014; 23: 282–287.
41.
LindenCQvarlanderSJóhannessonG, et al. Normal-tension glaucoma has normal intracranial pressure: a prospective study of intracranial pressure and intraocular pressure in different body positions. Ophthalmology2018; 125: 361–368.
42.
KiuchiTMotoyamaYOshikaT.Postural response of intraocular pressure and visual field damage in patients with untreated normal-tension glaucoma. J Glaucoma2010; 19: 191–193.
43.
YXXuLZhangXHYouQS, et al. Five-year change in intraocular pressure associated with changes in arterial blood pressure and body mass index. The Beijing Eye Study. PLoS One2013; 8: e77180.
44.
XuLWangHWangY, et al. Intraocular pressure correlated with arterial blood pressure: the Beijing eye study. Am J Ophthalmol2007; 144: 461–462.
45.
LeeJSChoiYRLeeJE, et al. Relationship between intraocular pressure and systemic health parameters in the Korean population. Korean J Ophthalmol2002; 16: 13–19.
46.
TielschJMKatzJSommerA, et al. Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol1995; 113: 216–221.
47.
WuS-YNemesureBHennisA, et al. Nine-year changes in intraocular pressure the barbados eye studies. Arch Ophthalmol2006; 124: 1631–1636.
48.
Asejczyk-WidlickaMKrzyzanowska-BerkowskaPSanderBP, et al. Age-related changes in ocular blood velocity in suspects with glaucomatous optic disc appearance. Comparison with healthy subjects and glaucoma patients. PLoS One2015; 10: e0134357.
49.
Asejczyk-WidlickaMKrzyzanowska-PiotrowskaPKowalskaM, et al. Clinical utility of spectral analysis of intraocular pressure pulse wave. BMC Ophthalmol2014; 14: 30.
