To investigate the rate of bleb-related endophthalmitis over 5 years in a Chinese population.
Methods
Retrospective chart review.
Results
Of 988 trabeculectomies performed over 5 years, one case (0.1%) developed early endophthalmitis caused by Morganella morganii, which was rarely reported in the literature. Six cases (0.6%) developed late-onset endophthalmitis. Mitomycin C significantly increased the risk of late-onset endophthalmitis (p=0.0002).
Conclusions
Physicians should weigh the benefits against the risks of mitomycin C application in performing trabeculectomies.
HigginbothamE.J., StevensR.K., MuschD.C.Blebrelated endophthalmitis after trabeculectomy with mitomycin C. Ophthalmology1996; 103: 650–6.
3.
KatzL.J., CantorL.B., SpaethG.L.Complications of surgery in glaucoma. Early and late bacterial endophthalmitis following glaucoma filtering surgery. Ophthalmology1985; 92: 956–63.
4.
HattenhauerJ.M., LipsichM.P.Late endophthalmitis after filtering surgery. Am J Ophthalmol1971; 72: 1097–101.
5.
BrownR.H., YangL.H., WalkerS.D., LynchM.G., MartinezL.A., WilsonL.A.Treatment of bleb infection after glaucoma surgery. Arch Ophthalmol1994; 112: 57–61.
6.
WolnerB., LeigmannJ.M., SassanJ.W., RitchR., SpeakerM., MarmorM.Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. Ophthalmology1991; 98: 1053–60.
7.
TabbaraK.F.Late infections following filtering procedures. Ann Ophthalmol1976; 8: 1228–31.
8.
FreedmanJ., GuptaM., BunkeA.Endophthalmitis after trabeculectomy. Arch Ophthalmol1978; 96: 1017–8.
9.
SugarH.S., ZekmanT.Late infection of filtering conjunctival scars. Am J Ophthalmol1958; 46: 155–70.
CiullaT.A., BeckA.D., TopingT.M., BakerA.S.Blebitis, early endophthalmitis, and late endophthalmitis after glaucoma-filtering surgery. Ophthalmology1997; 104: 986–94.
12.
GreenfieldD.S., SunerI.J., MillerM.P., KangasT.A., PalmbergP.F., FlynnH.W.Jr.. Endophthalmitis after filtering surgery with mitomycin. Arch Ophthalmol1996; 114: 943–9.
13.
O'HaraC.M., BrennerF.W., MillerM.Classification, identification, and clinical significance of Proteus, Providencia, and Morganella. Clin Microbiol Rev2000; 13: 534–46.
14.
LehmannO.J., BunceB., MathesonM.M.Risk factors for development of post-trabeculectomy endophthalmitis. Br J Ophthalmol2000; 84: 1349–53.
ShieldsM.B., ScroggsM.W., SloopC.M., SimmonR.B.Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C. Am J Ophthalmol1993; 116: 673–83.
18.
PeymanG.A., HerbstR.Bacterial endophthalmitis. Treatment with intraocular injection of gentamicin and dexamethasone. Arch Ophthalmol1974; 91: 416–8.
19.
PeymanG.A., RoseM., SandersD.Intravitreal antibiotic injection and vitrectomy in acute bacterial endophthalmitis. Can J Ophthalmol1976; 11: 188–90.
20.
ForsterR., AbbottR., GelenderH.Management of infectious endophthalmitis. Ophthalmology1980; 87: 313–9.
21.
LaatikainenL., TarkkanenA.Early vitrectomy in the treatment of post-operative purulent endophthalmitis. Acta Ophthalmol (Copenh)1987; 65: 455–60.
22.
JettB.D., JensenH.G., AtkuriR.V., GilmoreM.S.Evaluation of therapeutic measures for treating endophthalmitis caused by isogenic toxin-producing and toxin-nonproducing Enterococcus faecalis strains. Invest Ophthalmol Vis Sci1995; 36: 9–15.