Incidence of Nonarteritic Anterior Ischemic Optic Neuropathy in Adult Chinese: The Beijing Eye Study

Abstract

Purpose.

To determine the incidence of optic nerve damage due to nonarteritic anterior ischemic optic neuropathy (NAION) in the adult Chinese population.

Methods.

The Beijing Eye Study, a population-based, longitudinal study which included 4439 subjects (age 40+ years) in 2006, was repeated in 2006. In the follow-up examination, 3169 (71.4%) subjects participated. Optic disc photographs were assessed. Diagnostic criteria for incident NAION were a small optic disc, segmental pallor, and loss of retinal nerve fiber layer and visual field in the follow-up examination, with a normal optic nerve head appearance at baseline.

Results.

New NAION was found in one eye, with an incidence rate of 0.03±0.03% per 5 years (mean ± standard error) (95% confidence interval: −0.03, 0.09), or about 1:16,000 subjects per year.

Conclusions.

Within a 5-year period, new NAION may develop in 1 out of 3200 adult Chinese, or 1:16,000 adult Chinese per year.

Keywords

Nonarteritic anterior ischemic optic neuropathy Visual field loss Visual impairment Low vision Blindness Small optic disc

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References

Hayreh

S.S.

, Joos

K.M.

, Podhajsky

P.A.

, Long

C.R.

Systemic diseases associated with non-arteritic anterior ischemic optic neuropathy. Am J Ophthalmol 1994; 118: 766–80.

Hayreh

S.S.

Acute ischemic disorders of the optic nerve: pathogenesis, clinical manifestations and management. Ophthalmol Clin North Am 1996; 9: 407–42.

Beck

R.W.

, Savino

P.J.

, Repka

M.X.

, Schatz

N.J.

, Sergott

R.C.

Optic disc structure in anterior ischemic optic neuropathy. Ophthalmo logy 1984; 91: 1334–7.

Johns

L.N.

, Arnold

A.C.

Incidence of nonarteritic anterior ischemic optic neuritis (AION. population based study). J Neuro-ophthalmol 1994; 14: 38–49.

Hattenhauer

M.G.

, Leavitt

J.A.

, Hodge

D.O.

Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 1997; 123: 103–7.

, Li

, Cui

Refractive error in urban and rural adult Chinese in Beijing. Ophthalmology 2005; 112: 1676–83.

Jonas

J.B.

, Xu

Optic disc morphology in eyes after nonarteritic anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci 1993; 34: 2260–5. [QUERY: Please cite ref. 7 in text]