Impaired Neural Conduction in Crossed Visual Pathways in Patients with Ocular Hypertension

Abstract

Purpose

To evaluate the neural conduction along crossed and uncrossed visual pathways in patients with ocular hypertension (OHT).

Methods

Fifteen patients (mean age 59.1 ± 6.8 years) with OHT (IOP>22 mmHg, Humphrey 24-2 with mean deviation [MD]> −2 dB) were enrolled. They were compared to 15 age-matched controls. In OHT patients and control subjects, visual evoked potentials (VEPs) were recorded using full-field checkerboard patterns (the check subtended 15' of visual arc; contrast 80%) reversed at 2 Hz. VEP responses were simultaneously recorded in the homolateral visual cortex (HC) and in the contralateral visual cortex (CC), with respect to the stimulated eye.

Results

In OHT patients, VEP P100 implicit times observed in HC and CC were both significantly delayed (analysis of variance, p<0.01) when compared to those of controls, and, in particular, longer in CC than in HC. The interhemispheric differences (ID: P100 implicit time in HC – P100 implicit time in CC) were significantly higher in OHT patients than controls (–3.16±1.80 msec and 1.16 ± 1.04 msec, respectively, p=0.001). In OHT patients we observed an MD hemifield difference (difference between nasal and temporal MD values) higher than in controls (–0.82±0.80 dB and 0.04±1.03 dB, respectively, p<0.01) and significantly correlated with the ID (r: 0.836, p<0.001).

Conclusions

The observed asymmetry in the bioelectrical cortical responses and in the visual hemifield parameters suggests that crossed visual pathways could be impaired earlier than uncrossed visual pathways in OHT patients.