Biochemical markers of inflammation have been used in recent physical activity intervention studies. However, these same biochemical markers, mainly proinflammatory cytokines, may also be influenced by the individual’s level of stress and mood. Accordingly, this pilot study was implemented to determine the effect of a physical activity intervention on perceived stress, mood, quality of life, serum interleukin-6 (IL-6), and cortisol among 10 older adults, age 60 to 90. The results were compared to those of 10 older adults who were not engaging in regular physical activity. The 10-week intervention was applied using student nurses who taught the older adults how to calculate 60% of their maximum heart rate while ambulating for 30-min intervals. After the 10-week period, the participants in the exercise group reported significant improvements in stress, mood, and several quality of life indices. They also demonstrated a significant decrease in serum IL-6. Stress, mood, and quality of life scores in the exercise group were also significantly improved compared to the control group. This study adds information on the specific intensity, duration, and frequency of exercise necessary to achieve improvements in psychological variables and IL-6 levels. It also supports the need to measure psychological stress in physical activity intervention studies. Although the psychological variables were highly correlated, there were only weak correlations found with IL-6, suggesting that other factors are likely involved in reducing IL-6 when engaging in low-impact physical activity.
Ader, R., Felten, D. L., & Cohen, N. (2001). Preface. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (3rd ed.). New York: Academic Press.
2.
Besedovsky, H. O., & Rey, A. D. (2001). Cytokines as mediators of central and peripheral immune-neuroendocrine interactions. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (3rd ed., pp. 471-482). New York: Academic Press.
3.
Biondi, M., Moynihan, J. A., Stevens, S. Y., Lysle, D. T., Kusnecov, A. W., Sved, A., et al. (2001). Stress and immunity. In R. Ader & D. L. Felten (Eds.), Psychoneuroimmunology (pp. 189-345). New York: Elsevier.
4.
Biondi, M., & Picardi, A. (1999). Psychological stress and neuroendocrine function in humans: The last two decades. Psychotherapy and Psychosomatics, 68, 114-150.
5.
Blumenthal, J. A., Emery, C. F., & Madden, D. J. (1989). Cardiovascular and behavioral effects of aerobic exercise training in healthy older men and women. Journal of the Gerontological Medical Science, 44, M147-M157.
6.
Brawely, L. R., Rejeski, W. J., & Lutes, L. (2000). A group mediated cognitive-behavioral intervention for increasing adherence to physical activity in older adults. Journal of Applied Behavioral Research, 5(1), 47-65.
7.
Brown, J. D. (1991). Staying fit and staying well: Physical fitness as a moderator of life stress. Journal of Personality and Social Psychology, 60, 555-561.
8.
Butcher, S. K., & Lord, J. M. (2004). Stress responses and innate immunity: Aging as a contributory factor. Aging Cell, 3, 151-160.
9.
Cella, D. (1996). Quality of life outcomes: Measurement and validation. Oncology, 11, S233-S246.
10.
Cella, D. (1998). Quality of life. In J. C. Holland (Ed.), Psychooncology (p. 98-98). New York: Oxford University Press.
11.
Chrousos, G. P. (1992). Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. Endocrinology and Metabolism Clinics of North America, 21, 833-858.
12.
Cohen, H. J., Pieper, C. F., Harris, T. B., Rao, K. M., & Currie, M. S. (1997). The association of plasma IL-6 levels with functional disability in community-dwelling elderly. Journal of Gerontology and Biological Science Medical Science, 52A, M201-M208.
13.
Cohen, S. (1994). Perceived stress scale. Palo Alto, CA: Mind Garden.
14.
Cohen, S., Hamrick, N., Rodriguez, M. S., Feldman, P. J., Rabin, B. S., & Manuck, S. B. (2002). Reactivity and vulnerability to stress-associated risk for upper respiratory illness. Psychosomatic Medicine, 64, 302-310.
15.
Cohen, S., Kamarch, T., & Mermelstein, R. (1983). A global measure of perceived stress. Journal of Health and Social Behavior, 24, 385-396.
16.
Colbert, L. H., Visser, M., Simonsick, E. M., Tracy, R. P., Newman, A. B., Kritchevsky, S. B., et al. (2004). Physical activity, exercise, and inflammatory markers in older adults: Findings from the Health, Aging, and Body Composition Study. Journal of the American Geriatrics Society, 52, 1098-1104.
17.
Crist, D. M., Mackinnon, L. T., Thompson, R. F., Atterbom, H. A., & Egan, P. A. (1989). Physical exercise increases natural cellular-mediated tumor cytotoxicity in elderly women. Gerontology, 35, 66-71.
18.
Elavsky, S., McAuley, E., Motl, R. W., Konopack, J. F., Marquez, D. X., Hu, L., et al. (2005). Physical activity enhances long-term quality of life in older adults: efficacy, esteem and affective influences. Annals of Behavioral Medicine, 30, 138-145.
19.
Ershler, W. B., & Keller, E. T. (2000). Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annual Review of Medicine, 51, 245-270.
20.
Fahlman, M., Boardley, D., Flynn, M. G., Braun, W. A., Lambert, C. P., & Bouillon, L. E. (2000). Effects of endurance training on selected parameters of immune function in elderly women. Gerontology, 46, 97-104.
21.
Ferrari, E., Casarotti, D., Muzzoni, B., Albertelli, N., Cravello, L, Fioravanti, M., et al. (2001). Age-related changes of the adrenal secretory pattern: Possible role in pathological brain aging. Brain Research Review, 37, 294-300.
22.
Ferrucci, L., Penninx, B. W. J., Volpato, S., Harris, T. B., Bandeen-Roche, K., Balfour, J., et al. (2002). Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. Journal of the American Geriatrics Society, 50, 1947-1954.
23.
Ferrucci, L., Harris, T., Guranlnik, J., Tracy, R., Corti, M., Cohen, H., et al. (1999). Serum IL-6 level and the development of disability in older persons. Journal of the American Geriatric Society, 47, 639-646.
24.
Fleshner, F. (2005). Physical activity and stress resistance: Sympathetic nervous system adaptations prevent stress-induced immunosuppression. The American College of Sports Medicine, 33, 120-126.
25.
Folkins, C. H., & Sime, W. E. (1981). Physical fitness training and mental health. American Psychologist, 36, 373-389.
26.
Grubeck-Loebenstein, B., & Wick, G. (2002). The aging of the immune system. Advances in Immunology, 80, 243-284.
27.
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., et al. (1999). Association of elevated IL-6 and C-reactive protein levels with mortality in the elderly. American Journal of Medicine, 106, 506-512.
28.
High, K. P. (2004). Infection as a cause of age-related morbidity and mortality. Aging Research Reviews, 3, 1-14.
29.
Jankord, R., & Jemiolo, B. (2004). Influence of physical activity on serum IL-6 and IL-10 levels in healthy older men. Medicine and Science in Sports and Exercise, 36, 960-964.
30.
Kain, Z. N., Sevarino, F., Alexander, G. M., Pincus, S., & Mayes, L. C. (2000). Preoperative anxiety and postoperative pain in women undergoing hysterectomy: A repeated measures design. Journal of Psychosomatic Medicine, 49, 417-422.
31.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. The National Academy of Sciences of the United States of America, 100, 9090-9095.
32.
King, A. C., Pruitt, L. A., Phillips, W., Oka, R., Rodenburg, A., & Haskell, W. L. (2000). Comparative effects of two physical activity programs on measured and perceived physical functioning and other health-related quality of life outcomes in older adults. The Journal of Gerontology, 55A, M74-M83.
33.
Kohut, M. L., Lee, W., Martin, A., Arnston, B., Russell, D. W., Ekkekakis, P., et al. (2005). The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults. Brain, Behavior and Immunity, 19, 357-366.
34.
Kop, W. J., & Cohen, N. (2001). Psychological risk factors and immune system involvement in cardiovascular disease. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (3rd ed., pp. 525-544). New York: Academic Press.
35.
Lee, W., Senchina, D., Martin, A., Karandikar, A., Konopka, D., & Kohut, M. (2004). Long-term moderate exercise improves T-cell proliferation in older adults. Medicine and Science in Sports and Exercise, 36, S228-S228.
36.
Leng, S., Chaves, P., Koenig, K., & Walston, J. (2002). Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study. Journal of the American Geriatrics Society, 50, 1268-1271.
37.
Mazzeo, R. S., Cavanaugh, P., Evans, W. J., Fiatarone, M., Hagberg, J., McAuley, E., et al. (1998). Exercise and physical activity for older adults: American College of Sports Medicine Position Stand. Medicine & Science in Sports & Exercise, 30, 992-1008.
38.
McMurdo, M., & Burnett, L. (1992). A controlled trial of exercise by residents of old people’s homes. Age & Ageing, 22, 11-15.
39.
McNair, D. M., Lorr, M., & Droppleman, L. (1992). The manual for the Profile of Mood States. San Diego, CA: Educational and Industrial Testing Services.
40.
Mihalko, S. L., & McAuley, E. (1996). Strength training effects on subjective well being and physical function in the elderly. Journal of Aging & Physical Activity, 4, 56-68.
41.
Netz, Y., Wu, M. J., Becker, B. J., & Tenenbaum, G. (2005). Physical activity and psychological well-being in advanced age: A meta-analysis of intervention studies. Psychology & Aging, 20, 272-284.
42.
Nieman, D. C., Henson, D. A., Gusewitch, G, Warren, B. J., Dotson, R. C., Butterworth, D. E., et al. (1993). Physical activity and immune function in elderly women. Medicine & Science in Sports & Exercise, 25, 823-831.
43.
Prat, A., & Antel, J. P. (2001). Neuroendocrine influences on autoimmune disease: Multiple sclerosis. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (3rd ed., pp. 433-448). New York: Academic Press.
44.
Rejeski, W. D., & Milhalko, S. I. (2001). Physical activity and quality of life in older adults. The Journal of Gerontology, 56A, 23-35.
45.
Reuben, D. B., Judd-Hamilton, L., Harris, T. B., & Seeman, T. E. (2003). The associations between physical activity and inflammatory markers in high functioning older persons: MacArthur studies of successful aging. JAGS, 51, 1125-1130.
46.
Thomas, S. L., & Hall, A. J. (2004). What does epidemiology tell us about risk factors for herpes zoster?Lancet Infectious Diseases, 4, 26-33.
47.
Ware, J. E., Kosinski, M., & Dewey, J. E. (2002). How to score version 2 of the SF-36 health survey. Lincoln, RI: Medical Outcomes Trust and Quality Metric Incorporated.
48.
Watkins, L. R., & Maier, S. F. (2000). The pain of being sick: Implications of immune-to-brain communication for understanding pain. Annual Review of Psychology, 51, 29-57.
49.
Witek-Janusek, L., & Mathews, H. L. (2000). Stress, immunity and health outcomes. In V. H. Rice (Ed.), Handbook of stress, coping and health (pp. 47-68). London: Sage.
50.
Woods, J. A., Ceddia, M. A., Wolters, B. W, Evans, J. K., Lu, Q., & McAuley, E. (1999). Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mechanisms of Ageing and Development, 109, 1-19.
51.
Woods, J. A., Lowder, T. W., & Keylock, K. T. (2002). Can exercise training improve immune function in the aged?Annals of the New York Academy of Sciences, 959, 117-127.
52.
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., et al. (2003). Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology, 61, 76-80.
