Experimental blast response and quasi-static material property data were obtained for E-glass and carbon face skin sandwich composite panels with balsa, polyvinyl chloride foam, and TYCOR® cores. The pressure versus impulse (P–I) curve methodology enabled the generation of a database of performance envelopes for these sandwich composite panel configurations under different blast loading scenarios. The strength versus deformation properties of various undamaged sandwich composite panels are established numerically and idealized for single-degree-of-freedom modeling. Results show good correspondence between model predictions and experimental results for performance evaluation of the various sandwich composite structural panel configurations that were investigated.