Clinical,pathological,immunohistochemical and molecular characterization of feline chronic gingivostomatitis

Abstract

Veronica Machado Rolim, Saulo Petinatti Pavarini, Fabrício Souza Campos, Viviam Pignone, Cláudia Faraco, Marcelo de Souza Muccillo, Paulo Michel Roehe, Fernanda Viera Amorim da Costa, and David Driemeier J Feline Med Surg. Epub ahead of print 8 February 2016. DOI: 10.1177/1098612X16628578

This Corrigendum relates to the OnlineFirst version only (Epub ahead of print, published 8 February 2016). The abstract that appears on page 403 of the April 2017 issue of JFMS in print and online is the corrected version.

Readers should note that the OnlineFirst version of the article ‘Clinical, pathological, immunohistochemical and molecular characterization of feline chronic gingivostomatitis’ contains some errors in the abstract and the results section. The authors apologise for the errors.

The following amendments apply within the abstract:

1. Percentages were corrected to match those within the text of the article. The amended percentages appear in bold below.

2. From the results section, ‘and dyspnea (5.5%)’ was removed.

3. From the results section, the sentence ‘FIV antigens were identified in the inflammatory infiltrate of one cat’ was removed.

The corrected abstract appears in full below.

Objectives This study presents the clinical, pathological, immunohistochemical and molecular characterization of 26 cats with feline chronic gingivostomatitis (FCG).

Methods Oral mucosal biopsies, blood and swabs were collected from cats presenting with oral lesions. The tissue sections were submitted for histopathology and immunohistochemical analysis for feline calicivirus (FCV), feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). The swabs were subjected to PCR analysis for FCV, and blood for FeLV and FIV.

Results The main clinical findings were dysphagia (88.2%), halitosis (76.5%), sialorrhea (47.1%), weight loss (41.2%), intense oral discomfort (35.3%), oral hemorrhage (17.6%), and lackluster and fragile coat (11.8%). Gross inspection revealed bilateral lesions across the palatoglossal fold to the lateral tongue base. The lesions were diffuse, proliferative, intensely red and friable, and bled easily upon examination in 80.8% of cases. In 23.1% of cases, the lesions were multifocal to coalescent, at times forming multiple vesicles on a reddened, edematous palatoglossal fold. Microscopic examination showed that 15.4% of lesions had moderate (grade 2) and 84.6% had severe (grade 3) inflammation. Immunohistochemistry revealed the presence of FeLV antigens in the epithelium and the inflammatory infiltrate of 30.8% of the cats with FCG. FCV antigens were not detected in the FCG lesions.

Conclusions and relevance The FCG cases analyzed could not be correlated with FCV. It is possible that FeLV plays a role as a causal agent of lesions in cases where the presence of the virus has been confirmed by immunohistochemistry in epithelial samples.

The following amendments apply within the Online First article:

1. Page 3, Evaluation of patients. A percentage of 74% and the number of cats 6/20 were corrected to: 77% and 5/20.

2. Page 3, Clinical evaluation. A percentage of 65.3 was corrected to 65.4.

3. Page 3, Clinical evaluation. A subsequent percentage of 11.1% and the number of cats 2/18 were corrected to: 11.8% and (2/17).