This overview of mesenchymal tumors presenting in the skin and/or subcutis in children brings together the range of neoplasms and hamartomas which are seen in this age-group. It is not surprising from the perspective of the pediatric or general surgical pathologist that vascular anomalies, including true neoplasms and vascular malformations, are the common phenotypic category. Since there is considerable morphologic overlap among these lesions, clinicopathologic correlation may be more important than for many of the other mesenchymal tumors. The skin and subcutis are the most common sites of clinical presentation for the infantile myofibroma which is the most common of fibrous mesenchymal tumors in children. Several of the other mesenchymal tumors are more common adults-like dermatofibrosarcoma protuberans, but nonetheless have an important presence in children, even as a congenital neoplasm. A lipomatous tumor in a young child should be considered as a possible manifestation of an overgrowth syndrome.
LópezVMartinJMMonteagudoCJordáE. Epidemiology of pediatric dermatologic surgery: a retrospective study of 996 children. Actas Dermosifiliogr2010; 101: 771–777.
2.
CoffinCMAlaggioRDehnerLP. Some general considerations about the clinicopathologic aspects of soft tissue tumors in children. Pediatr Dev Pathol2012; 15(suppl): 11–25.
3.
Tukenmez DemirciGAtisGKivanc AltunayISakizD. The epidemiology of non-melanocytic benign and malignant skin tumors in pediatric patients attending to the dermatology department. J Clin Med Res2015; 7: 770–774.
4.
HoegerPHColmeneroI. Vascular tumours in infants. Part I: benign vascular tumours other than infantile haemangioma. Br J Dermatol2014; 171: 466–473.
5.
MullikenJBClassification of vascular anomalies. In: MullikenJBBurrowsPEFishmanSJ (eds). Mulliken and Young’s Vascular Anomalies. Hemangiomas and Malformations, 2nd ed. New York, NY: Oxford University Press, 2013, pp. 22–39.
6.
HarrisMNDesaiRChuangTYHoodAFMirowskiGW. Lobular capillary hemangiomas: an epidemiologic report, with emphasis on cutaneous lesions. J Am Acad Dermatol2000; 42: 1012–1016.
7.
ChenDHuXJLinXXet al.Nodules arising within port-wine stains: a clinicopathologic study of 31 cases. Am J Dermatopathol2011; 33: 144–151.
8.
PagliaiKACohenBA. Pyogenic granuloma in children. Pediatr Dermatol2004; 21: 10–13.
9.
BarrackBLehmanJTollefsonM. Agminated pyogenic granuloma-like growth arising in a congenial hemangioma. JAMA Dermatol2014; 150: 781–783.
10.
DastgheibLAslaniFS. Infantile multiple large pyogenic granuloma on burned skin. Case report and review of literature. An Bras Dermatol2016; 91: 212–214.
11.
XuYLiHWangZXYangS. Multiple eruptive pyogenic granulomas occurring in a region of scalded skin. Pediatr Dermatol2016; 33: e27–e28.
12.
SenserMDerancourtCBlancDVan LanduytHLaurentR. [Recurrent pyogenic granuloma or Warner and Wilson-Jones syndrome]. Arch Pediatr1997; 4: 653–655.
13.
PutraJRymeskiBMerrowACDasguptaRGuptaA. Four cases of pediatric deep-seated/subcutaneous pyogenic granuloma: review of literature and differential diagnosis. J Cutan Pathol2017; 44(6): 516–522.
14.
Mariño-SánchezFLopez-ChaconMJouCHaagO. Pediatric intranasal lobular capillary hemangioma: Report of two new cases and review of the literature. Respir Med Case Rep2016; 18: 31–34.
15.
Barasoain-MillánARodriguez-ContrerasFJGuerrero-GernandezJMerinoMBGonzalez-CasadoI. Pyogenic granuloma, an unusual presentation of peripubertal vaginal bleeding. Case report and review of the literature. J Pediatr endocrinol Metab2015; 28(3–4): 443–447.
16.
BarrKLVincekV. Subcutaneous intravascular pyogenic granuloma: a case report and review of the literature. Cutis2010; 86: 130–132.
17.
PantanowitzLDukeWH. Intravascular lesions of the hand. Diagn Pathol2008; 3: 24.
18.
McElroyAKHilinskiJAAbramowskyCRJaffeRParkSIShehataBMCooperTM. Bacillary angiomatosis in patients with cancer: a pediatric case report and a review of the literature. J Pediatric Infect Dis Soc2013; 2: 175–178.
19.
ZarragaMRosenLHerschthalD. Bacillary angiomatosis in an immunocompetent child: a case report and review of the literature. Am J Dermatopathol2011; 33: 513–515.
20.
LimYHDouglasSRKoCJet al.Somatic activating RAS mutations cause vascular tumors including pyogenic granuloma. J Invest Dermatol2015; 135: 1698–1700.
21.
GroesserLPeterhofEEvertMLandthalerMBerneburgMHafnerC. BRAF and RAS mutations in sporadic and secondary pyogenic granuloma. J Invest Dermatol2016; 136: 481–486.
22.
van SteenselMA. The growing spectrum of cutaneous RASopathy. J Invest Dermatol2016; 136: 359–360.
23.
BlackwellMGItinteangTChibnallAMDavisPFTanST. Expression of embryonic stem cell markers in pyogenic granuloma. J Cutan Pathol2016; 43: 1096–1101.
24.
Wetzel-StrongSEDetterMRMarchukDA. The pathology of vascular malformations: insights from human and model organism genetics. J Pathol2017; 241: 281–293.
EngCPTEN hamartoma tumor syndrome. In: PagonRAAdamMPArdingerHHet al.(eds). GeneReview® [Internet], Seattle, WA: University of Washington, 2001.
27.
LuksVLKamitakiNViveroMPet al.Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. J Pediatr2015; 166: 1048–1054.
28.
BleiF. Overgrowth syndromes with vascular anomalies. Curr Probl Pediatr Adolesc Health Care2015; 45: 118–131.
29.
KirkorianAYGrossbergALPuttgenKB. Genetic basis for vascular anomalies. Semin Cutan Med Surg2016; 35: 128–136.
30.
ClemensRKPfammatterTMeierTOAlomariAIAman-VestiBR. Combined and complex vascular malformations. Vasa2015; 44: 92–105.
31.
LianCGShollLMZakkaLRet al.Novel genetic mutations in a sporadic port-wine stain. JAMA Dermatol2014; 150(12): 1336–1340.
SundaramSKMichelhaughSKKlingerNVet al.GNAQ Mutation in the Venous Vascular Malformation and Underlying Brain Tissue in Sturge-Weber Syndrome. Neuropediatrics2017; 48(5): 385–389.
34.
ShirleyMDTangHGallioneCJet al.Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med2013; 368(21): 1971–1979.
35.
McDonaldJWooderchak-DonahueWVanSant WebbCWhiteheadKStevensonDBayrak-ToydemirP. Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostic in a new era. Front Genet2015; 6: 1.
36.
DompmartinAVikkulaMBoonLM. Venous malformation: update on etiopathogenesis, diagnosis and management. Phlebology2010; 25: 224–235.
37.
BoonLMMullikenJBEnjolrasOVikkulaM. Glomuvenous malformation (glomangioma) and venous malformation: distinct clinicopathology and genetic entities. Arch Dermatol2004; 140: 971–976.
38.
BrouillardPBoonLMRevencuNet al.Genotypes and phenotypes of 162 families with a glomulin mutation. Mol Syndromol2013; 4: 157–164.
39.
ShaikhRAlomariAIMullikenJBFishmanSJKozakewichHPWChaudryG. Subfascial involvement in glomuvenous malformation. Skeletal Radiol2014; 43: 895–897.
40.
WoutersVLimayeNUebelhoerMet al.Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyperphosphorylating effects. Eur J Hum Genet2010; 18: 414–420.
41.
SobletJLimayeNUebelhoerMBoonLMVikkulaM. Variable somatic TIE2 mutations in half of sporadic venous malformations. Mol Syndromol2013; 4: 179–183.
42.
Al DhaybiRPowellJMcCuaigCKoktaV. Differentiaion of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: evaluation of 126 cases. J Am Acad Dermatol2010; 63: 1052–1057.
43.
Aneiros-FernandezJRetameroJAHusein-ElAhmedHet al.Smoothelin and WT-1 expression in glomus tumors and glomuvenous malformations. Histol Histopathol2017; 32: 153–160.
44.
MundenAButschekRTomWet al.Prospective study of infantile hemangiomas: Incidence, clinical characteristics and association with placental anomalies. Br J Dermatol2014; 170: 907–913.
45.
QiuMQiXDaiYWangSQuanZLiuYOuJ. Infantile haemangioma: a complicated disease. Front Biosci (Landmark Ed)2015; 20: 1004–1016.
46.
KilclineCFriedenIJ. Infantile hemangiomas: How common are they? A systematic review of the medical literature. Pediatr Dermatol2008; 25: 168–173.
47.
GoelzRPoetsCF. Incidence and treatment of infantile haemangioma in preterm infants. Arch Dis Child Fetal Neonatal Ed2015; 100: F85–F91.
48.
CastrénESalminenPGisslerMStefanovicVPitkärantaAKlockarsT. Risk factors and morbidity of infantile haemangioma: preterm birth promotes ulceration. Acta Paediatr2016; 105: 940–945.
49.
SelminAFoltranFChiarelliSCiulloRGregoriD. An epidemiological study investigating the relationship between chorangioma and infantile hemangioma. Pathol Res Pract2014; 210: 548–553.
50.
CastrénESalminenPVikkulaMPitkäranta, KlockarsT. Inheritance patterns of infantile hemangioma. Pediatrics2016; 138(5): e20161623.
51.
GarzonMCEpsteinLGHeyerGLet al.PHACE syndrome: Consensus-derived diagnosis and care recommendations. J Pediatr2016; 178: 24–33.
52.
WeitzNABayerMLBaselgaEet al.The “biker-glove” pattern of segmental infantile hemangiomas on the hands and feet. J Am Acad Dermatol2014; 71: 542–547.
53.
ReimerAFliesserMHoegerPH. Anatomical patterns of infantile hemangioma (IH) of the extremities (IHE). J Am Acad Dermatol2016; 75: 556–563.
54.
LuuMFriedenIJ. Infantile hemangiomas and structural anomalies: PHACE and LUMBAR syndrome. Semin Cutan Med Surg2016; 35: 117–123.
55.
IacobasIBurrowsPEFriedenIJet al.LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. J Pediatr2010; 157: 795–801.
NorthPEWanerMMizerackiAMihmMCJr. GLUT–1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol2000; 31: 11–22.
58.
AhrensWaRidenourRVIIICaronBLMillerDVFolpeAL. GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms. Hum Pathol2008; 39: 1519–1526.
59.
MullikenJBDiagnosis and natural history of hemangiomas. In: MullikenJBBurrowsPEFishmanSJ (eds). Mulliken and Young’s Vascular Anomalies: Hemangiomas and Malformations2013; Vol 4, New York, NY: Oxford University Press, pp. 68–110.
60.
MaEHRobertsonSJChowCWBekhorPS. Infantile hemangioma with minimal or arrested growth: Further observations on clinical and histopathologic findings of this unique but underrecognized entity. Pediatr Dermatol2017; 34: 64–71.
ItinteangTWithersAHDavisPFTanST. Biology of infantile hemangioma. Front Surg2014; 25;1: 38.
64.
GreenbergerSBischoffJ. Pathogenesis of infantile haemangioma. Br J Dermatol2013; 169: 12–19.
65.
FilippiLDal MonteMCasiniGDaniottiMSereniFBagnoliP. Infantile hemangiomas, retinopathy of prematurity and cancer: a common pathogenetic role of the β-adrenergic system. Med Res Rev2015; 35: 619–652.
66.
JanmohamedSRMadernGCde LaatPCOranjeAP. Educational paper: pathogenesis of infantile haemangioma, an update 2014 (part I). Eur J Pediatr2015; 174: 97–103.
67.
ItinteangTTanSTGuthrieSTanCEMcIntyreBCBraschHDDayDJ. A placental chorionic villous mesenchymal core cellular origin for infantile haemangioma. J Clin Pathol2011; 64: 870–874.
68.
SpockCLTomLKCanadasKet al.Infantile hemangiomas exhibit neural crest and pericyte markers. Ann Plast Surg2015; 74: 230–236.
69.
GreenbergerSBischoffJ. Pathogenesis of infantile haemangioma. Br J Dermatol2013; 169(1): 12–19.
GreenbergerSBoscoloEAdiniIMullikenJBBischoffJ. Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med2010; 362(11): 1005–1013.
72.
JinninMMediciDParkLet al.Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med2008; 14(11): 1236–1246.
73.
MaXZhaoTOuyangTXinSMaYChangM. Propranolol enhanced adipogenesis instead of induction of apoptosis of hemangiomas stem cells. Int J Clin Exp Pathol2014; 7(7): 3809–3817.
74.
LiangMGFriedenIJ. Infantile and congenital hemangiomas. Semi Pediatr Surg2014; 23: 162–167.
75.
BerenguerBMullikenJBEnjolrasOet al.Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol2003; 6: 495–510.
76.
MullikenJBEnjolrasO. Congenital hemangiomas and infantile hemangioma: Missing links. J Am Acad Dermatol2004; 50: 875–882.
77.
LeePWFreidenIJStreicherJIMcCalmontTHaggstromAN. Characteristics of noninvoluting congenital hemangioma: A retrospective review. J Am Acad Dermatol2014; 70: 899–903.
NasseriEPiramMMcCuaigCCKoktaVDuboisJPowellJ. Partially involuting congenital hemangiomas: A report of 8 cases and review of the literature. J Am Acad Dermatol2014; 70: 75–79.
80.
DevezaEPuzenatEManzoniPHumbertPAubinF. Congenital hemangiomas: Report on ten patients. Arch Pediatr2015; 22: 685–692.
81.
AyturkUMCoutoJAHannSet al.Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma. Am J Hum Genet2016; 98: 789–795.
82.
LimYHBacchiocchiAQuiJet al.GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation. Am J Hum Genet2016; 99: 443–450.
83.
AboutalebiAJessupCHNorthPEMihmMCJr. Histopathology of vascular anomalies. Facial Plast Surg2012; 28: 545–553.
84.
LeePWFreidenIJStreicherJIMcCalmontTHaggstromAN. Characteristics of noninvoluting congenital hemangioma: A retrospective review. J Am Acad Dermatol2014; 70: 899–903.
85.
NapekoskiKMFernandezAPBillingsSD. Microvenular hemangioma: a clinicopathologic review of 13 cases. J Cutan Pathol2014; 41: 816–822.
86.
LinosKCsapossJCarlsonJA. Microvenular hemangioma presenting with numerous bilateral macules, patches and plaques: a case report and review of the literature. Am J Dermatopathol2013; 35: 98–101.
87.
TrindadeFKutznerHRequenaL. Tellechea O, Colmenero I. Microvenular hemangioma-an immunohistochemical study of 9 cases. Am J Dermatopathol2012; 34: 810–812.
88.
WangLGaoTWangG. Verrucous hemangioma: a clinicopathological and immunohistochemical analysis of 74 cases. J Cutan Pathol2014; 41: 823–830.
HolcombMSunGEldinKBrandonK. Verrucous hyperpigmented plaque in a 15-month-old boy. Eccrine angiomatous hamartoma (EAH) associated with verrucous hemangioma (VH). Int J Dermatopathol2013; 52: 25–26.
94.
CoutoJAViveroMPKozakewichHPet al.A somatic MAP3K3 mutation is associated with verrucous venous malformation. Am J Hum Genet2015; 96(3): 480–486.
95.
CroteauSEGuptaD. The clinical spectrum of kaposiform hemangioendothelioma and tufted angioma. Semin Cutan Med Surg2016; 35: 147–152.
96.
ChuCYHsiaoCHChiuHC. Transformation between kaposiform hemangioendothelioma and tufted angioma. Dermatology2003; 206: 334–337.
97.
IshikawaKHantanoYIchikawaHHashimotoHFujiwaraS. The spontaneous regress of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature. Dermatology2005; 210: 346–348.
98.
AlberolaFTBetllochIMonteroLCNortesIBMartinezNLPazAM. Congenital tufted angioma: case report and review of the literature. Dermatol Online J2010; 16: 2.
99.
HerronMDCoffinCMVanderhooftSL. Tufted angiomas: variability of the clinical morphology. Pediatr Dermatol2002; 19: 394–401.
100.
OsioAFraitagSHadj-RabiaSBodemerCde ProstYHamel-TeillacD. Clinical spectrum of tufted angiomas in childhood. Arch Dermatol2010; 146: 758–763.
CroteauSELiangMGKozakewichHPet al.Kaposiform hemangioendothelioima: Atypical features and risks of Kasabach-Merritt phenomenon in 107 referrals. J Pediatr2013; 162: 142–147.
103.
PutraJGuptaA. Kaposiform haemangioendothelioma: a review with emphasis on histological differential diagnosis. Pathology2017; 49(4): 356–362.
GnarraMBehrGKitajewskiAet al.History of the infantile hepatic hemangioma: from imaging to generating a differential diagnosis. World J Clin Pediatr2016; 5: 273–280.
106.
ManivelJCWickMRSwansonPEPattersonKDehnerLP. Endovascular papillary angioendothelioma of childhood: a vascular lesion possibly characterized by “high” endothelial cell differentiation. Hum Pathol1986; 17: 1240–1244.
107.
LiBLiYTianXYLiZ. Unusual multifocal intraosseous papillary intralymphatic angioendothelioma (Dabska tumor) of facial bones: a case report and review of literature. Diagn Pathol2013; 8: 160.
108.
Fanburg-SmithJCMichalMPartanenTAAlitaloKMiettinenM. Papillary intralymphatic angioendothelioma (PILA): a report of twelve cases of a distinctive vascular tumor with phenotype features of lymphatic vessels. Am J Surg Pathol1999; 23: 1004–1010.
WardKAEckerPMWhiteRRMelnikTEBulbahceEHWilkeMSSanguezaOP. Papillary intralymphatic angioendothelioma of the thigh: A case report and review of the literature. Dermatol Online J2010; 16: 4.
111.
WachterDLAgaimyA. A cutaneous vascular neoplasm with hobnail microscopic morphology and unusual gross features. J Cutan Pathol2012; 39: 454–457.
112.
RangaSMKuchangiNCShankarVSAmitaKHaleuoorBBBelagolaSD. Retiform hemangioendothelioma: An uncommon pediatric vascular neoplasm. Indian J Dermatol2014; 59: 633.
113.
MotaAArgenzianoGZalaudekIet al.Clinical, dermoscopic and histopathologic findings of retiform hemangioendothelioma. Dermatol Pract Concept2013; 3: 11–14.
114.
ParsonsASheehanDJSanguezaOP. Retiform hemangioendotheliomas usually do not express D2-40 and VEGFR-3. Am J Dermatopathol2008; 30: 31–33.
115.
EmbergerMLaimerMSteinerHZelgerB. Retiform hemangioendothelioma: presentation of a case expressing D2-40. J Cutan Pathol2009; 36: 987–990.
116.
AlbertiniAFBrousseNBodemerCCalonjeEFraitagS. Retiform hemangiomendothelioma developed on the site of an earlier cystic lymphangioma in a six-year-old girl. Am J Dermatopathol2011; 33: e84–e87.
117.
DhaybiRALamCHatamiAPowellJMcCuaigCKoktaV. Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: a study of 12 pediatric cases. J Am Acad Dermatol2012; 66: 116–120.
118.
GuillouLCalonjeESpeightPRosaiJFletcherC. Hobnail hemangioma: A pseudomalignant vascular lesion with a reappraisal of targetoid hemosiderotic hemangioma. Am J Surg Pathol1999; 23: 97–105.
AbuHilalMBreslavetMHoNTaylorGPopeE. Hobnail hemangioma (superficial hemosiderotic lymphovascular malformation) in children: a series of 6 pediatric cases and review of the literature. J Cutan Med Surg2016; 20: 216–220.
121.
PerkinsPWeissSW. Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior. Am J Surg Pathol1996; 20: 1196–1204.
122.
PansuriyaTCvan EijkRd’AdamoPet al.Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nat Genet2011; 43: 1256–1261.
123.
ProkopchukOAndresSBeckerKHolzapfelKHartmannDFriessH. Maffucci syndrome and neoplasms: a case report and review of the literature. BMC Res Notes2016; 9: 126.
124.
KurekKCPansuriyaTCvan RulerMAet al.R123C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. Am J Pathol2013; 182: 1494–1500.
125.
WangLGaoTWangG. Expression of Prox1, D2-40 and WT1 in spindle cell hemangioma. J Cutan Pathol2014; 41: 447–450.
126.
FukunagaMSuzukiKSaegusaNFolpeAL. Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. Am J Surg Pathol2007; 31: 1567–1572.
127.
Reis-FilhoJSPaivaMELopesJM. Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum. J Cutan Pathol2002; 29: 226–231.
128.
AdlerBLKrauszAEMinutiASilverbergJILev-TovH. Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): a systematic review. J Am Acad Dermatol2016; 74: 506–512.
FetschJFWeissSW. Observations concerning the pathogenesis of epithelioid hemangioma (angiolymphoid hyperplasia). Mod Pathol1991; 4: 449–455.
131.
FontanaSCBorgstadtAFragaGRReevesARAndrewsBT. Angiolymphoid hyperplasia with eosinophilia within a vascular malformation: case report and review of the literature. Ann Otol Rhinol Laryngol2016; 125: 775–778.
132.
Al-AdnaniMWilliamsSRamplingDAshworthMMaloneMSebireNJ. Histopathological reporting of paediatric cutaneous vascular anomalies in relation to proposed multidisciplinary classification system. J Clin Pathol2006; 59: 1278–1282.
HungYPFletcherCDHornickJL. FOSB is a useful diagnostic marker for pseudomyogenic hemangioendothelioma. Am J Surg Pathol2017; 41(5): 596–606.
144.
WaltherCTayebwaJLilljebjörnHet al.A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma. J Pathol2014; 232(5): 534–540.
145.
HornickJLFletcherCD. Epithelioid Sarcoma like hemangioendothelioma (pseudomyogenic hemangioendothelioma). Am J Surg Pathol2011; 35(2): 190–201.
146.
WeissSWEnzingerFM. Epithelioid hemangioendothelioma. A vascular tumor often mistaken for a carcinoma. Cancer1982; 50: 970–981.
147.
QuanteMPatelNKHillSet al.Epithelioid hemangioendothelioma presenting in the skin. A clinicopathologic study of eight cases. Am J Dermatopathol1998; 20: 541–546.
148.
ForschnerAHarmsDMetzlerGet al.Ulcerated epithelioid hemangioendothelioma of the foot in childhood. J Am Acad Dermatol2003; 49: 113–116.
149.
EgbertsFMentzelTLeuschnerIMetzlerGFölster-HolstR. Metastasizing epoithelioid hemangioendothelioma of the nose in childhood. J Cutan Pathol2008; 35(suppl 1): 80–82.
150.
DeyrupATTighiouartMMontagAGWeissSW. Epithelioid hemangioendothelioma of the soft tissue. A proposal for risk classification based on 49 cases. Am J Surg Pathol2008; 32: 472–477.
151.
ErraniCZhangLSungYSet al.A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer2011; 50: 644–653.
152.
ChernoffKASchafferJV. Cutaneous and ocular manifestations of neurocutaneous syndromes. Clin Dermatol2016; 34: 183–204.
153.
RodriguezFJFolpeALGianniniCPerryA. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol2012; 123: 295–319.
MagroGAmicoPVecchioGMet al.Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases. Virchows Arch2010; 456: 71–76.
156.
FetschJFMichalMMiettinenM. Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients. Am J Surg Pathol2000; 24: 331–343.
157.
MotoiTIshidaTKawatoAMotoiNFukayamaM. Pigmented neurofibroma: review of Japanese patients with an analysis of melanogenesis demonstrating coexpression of c-met protooncogene and microphthalmia-associated transcription factor. Hum Pathol2005; 36: 871–877.
158.
NakashimaKYamadaNYoshidaYYamamotoO. Solitary sclerotic neurofibroma of the skin. Am J Dermatopathol2008; 30: 278–280.
159.
JokinenCHArgenyiZB. Atypical neurofibroma of the skin and subcutaneous tissue: clinicopathologic analysis of 11 cases. J Cutan Pathol2010; 37: 35–42.
160.
SaabStMcClainCMCoffinCM. Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol2014; 38: 394–401.
161.
AgaramNPZhangLSungYSChenCLChungCTAntonescuCRFletcherCD. Recurrent NTRK1 gene fusions define a noval subset of locally aggressive lipofibromatosis-like neural tumors. Am J Surg Pathol2016; 40: 1407–1416.
162.
WoodhooASommerL. Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. Gila2008; 56: 1481–1490.
163.
LloydSKWEvansDGR. Neurofibromatosis type 2 (NF2): diagnosis and management. Handb Clin Neurol2013; 115: 957–966.
164.
EvansDG. Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis2009; 4: 16.
165.
RuggieriMPraticoADEvandDG. Diagnosis, management, and new therapeutic options in childhood neurofibromatosis Type 2 and related forms. Semin Pediatr Neurol2015; 22: 240–258.
166.
MatsuoMOhnoKOhtsukaF. Characterization of early onset neurofibromatosis type 2. Brain Dev2014; 36: 148–152.
167.
RuggieriMIannettiPPolizziAet al.Earliest clinical manifestations and natural history of neurofibromatosis type 2 (NF2) in childhood: a study of 24 patients. Neuropediatrics2005; 36: 21–34.
168.
ReithJDGoldblumJR. Multiple cutaneous plexiform schwannomas. Report of a case and review of the literature with particular reference to the association with types 1 and 2 neurofibromatosis and schwannomatosis. Arch Pathol Lab Med1996; 120: 399–401.
169.
BergJCScheithauerBWSpinnerRJAllenCMKoutlasIG. Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region. Hum Pathol2008; 39: 633–640.
170.
MiyakawaTKamadaNKobayashiTet al.Neurofibromatosis type 2 in an infant with multiple plexiform schwannomas as first symptom. J Dermatol2007; 34: 60–64.
171.
WoodruffJMScheithauerBWKurtkaya-YapicierOet al.Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. Am J Surg Pathol2003; 27: 1321–1329.
172.
Meis-KindblomJMEnzingerFM. Plexiform malignant peripheral nerve sheath tumor of infancy and childhood. Am J Surg Pathol1994; 18: 479–485.
173.
PekmezciMReussDEHirbeACet al.Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol2015; 28: 187–200.
174.
Kurtkaya-YapicierOScheithauerBWoodruffJM. The pathologic spectrum of schwannomas. Histol Histopathol2003; 18: 925–934.
175.
HartJGardnerJMEdgarMWeissSW. Epithelioid schwannomas: An analysis of 58 cases including atypical variants. Am J Surg Pathol2016; 40: 704–713.
176.
LaskinWBFetschJFLasotaJMiettinenM. Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol2005; 29: 39–51.
177.
RezankoTSariAATunakanMCalliAOAltinbogaAA. Epithelioid schwannoma of soft tissue: unusual morphological variant causing a diagnostic dilemma. Ann Diagn Pathol2012; 16: 521–526.
178.
AntonescuCRLouisDNHuntenSPerryAReussDEStemmer-RachamimovAOSchwannoma. In: LouisDNOhgargiHWiestlerODCaveneeWK (eds). WHO Classification of Tumours of the Central Nervous System, 4th ed. Lyon, France: IARC, 2016, pp. 214–218.
179.
YamadaSKirshimaMHirakiTHigashiMHatanakaKTanimotoA. Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review. Diagn Pathol2017; 12: 11.
180.
StratakisCASalpeaPRaygadaMCarney complex. In: PagonRAAdamMPArdingerHHet al.(eds). GeneReview® [Internet], Seattle, WA: University of Washington, 2003.
181.
Torres-MoraJDrySLiXBinderSAminMFolpeAL. Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of “melanotic schwannoma.”Am J Surg Pathol2014; 38(1): 94–105.
182.
KhooMPressneyIHargunaniRTiraboscoR. Melanotic schwannoma: an 11-year case series. Skeletal Radiol2016; 45: 29–34.
183.
CarneyJA. Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol1990; 14: 206–222.
184.
CarneyJAFerreiroJA. The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanocytic schwannoma. Am J Surg Pathol1996; 20: 259–272.
185.
Reis-FilhoJSMilaneziFFerroJSchmittFC. Pediatric pigmented dermatofibrosarcoma protuberans (Bednár tumor): case report and review of the literature with emphasis on the differential diagnosis. Pathol Res Pract2002; 198: 621–626.
186.
MiettinenMMcCuePASarlomo-RikalaMet al.Sox-10–a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol2015; 39: 826–835.
187.
ThomasAKEgelhoffJCCurranJGThomasB. Pediatric schwannomatosis, a rare but distinct form of neurofibromatosis. Pediatr Radiol2016; 46: 430–435.
188.
MerkerVLEsparzaSSmithMJStemmer-RachamimovAPlotkinSR. Clinical features of schwannomatosis: A retrospective analysis of 87 patients. Oncologist2012; 17: 1317–1322.
189.
Kehrer-SawatzkiHFarschtschiSMautnerVFCooperDN. The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumor suppressor genes in tumorigenesis. Hum Genet2017; 136: 129–148.
190.
AgaimyA. The expanding family of SMARCB1(INI1)-deficient neoplasia: implications of phenotypic, biological, and molecular heterogeneity. Adv Anat Pathol2014; 21: 394–410.
191.
KohashiKOdaY. Oncogenic roles of SMARCB1/INI1 and its deficient tumors. Cancer Sci2017; 108(4): 547–552.
192.
Piña-OviedoSOrtiz-HidalgoC. The normal and neoplastic perineurium: a review. Adv Anat Pathol2008; 15: 147–164.
MacarencoRSEllingerFOliveiraAM. Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med2007; 131: 625–636.
195.
HornickJLFletcherCD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol2005; 29: 845–858.
196.
NascimentoAFFletcherCDM. The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol2007; 31: 1363–1370.
197.
MontgomeryBKAlimchandaniMMehtaGUet al.Tumors displaying hybrid schwannoma and neurofibroma features in patients with neurofibromatosis type 2. Clin Neuropathol2016; 35: 78–83.
198.
HarderAWesemannMHagelCet al.Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients. Am J Surg Pathol2012; 36: 702–709.
199.
HornickJLBundockEAFletcherCD. Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol2009; 33: 1554–1561.
200.
LaskinWBFetschJFMiettinenM. The “neurothekeoma”: immunohistochemical analysis distinguishes the true nerve sheath myxoma from it mimics. Hum Pathol2000; 31: 1230–1241.
201.
ArgenyiZBLeBoitPESanta CruzDSwansonPEKutznerH. Nerve sheath myxoma (neurothekeoma) of the skin: light microscopic and immunohistochemical reappraisal of the cellular variant. J Cutan Pathol1993; 20: 294–303.
202.
ShethSLiXBinderSDrySM. Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. Mod Pathol2011; 24: 343–354.
203.
StrattonJBillingsSD. Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features. Mod Pathol2014; 27: 701–710.
204.
JafferSAmbrosini-SpaltroAManciniAMEusebiVRosaiJ. Neurothekeoma and plexiform fibrohistiocytic tumor: mere histologic resemblance or histogenetic relationship?Am J Surg Pathol2009; 33: 905–913.
205.
AllenPW. Myxoma is not a single entity: a review of the concept of myxoma. Ann Diagn Pathol2000; 4: 99–123.
206.
MakinoTUtsunomiyaTKaminoYet al.Nerve sheath myxoma of the tongue in a child. Int J Oral Maxillofac Surg2002; 31: 451–454.
207.
SafadiRAHellsteinJWDiabMMHammadHM. Nerve sheath myxoma (neurothekeoma) of the gingiva, a case report and review of the literature. Head Neck Pathol2010; 2: 242–245.
LiuGYSongHXuXL. Multiple palisaded encapsulated neuromas in siblings: a case report and review of the published work. J Dermatopathol2016; 43: 560–563.
210.
FletcherCD. Solitary circumscribed neuroma of the skin (so-called palisaded, encapsulated neuroma). A clinicopathologic and immunohistochemical study. Am J Surg Pathol1989; 13: 574–580.
211.
MegahedM. Palisaded encapsulated neuroma (solitary circumscribed neuroma). A clinicopathologic and immunohistochemical study. Am J Dermatopathol1994; 16: 120–125.
TahiriYXuLKanevskyJLucM. Lipofibromatous hamartoma of the median nerve: a comprehensive review and systematic approach to evaluation, diagnosis and treatment. J Hand Surg Am2013; 38: 2055–2067.
225.
AgarwalSHaaseSC. Lipofibromatous hamartoma of the median nerve. J Hand Surg Am2013; 38: 392–397.
226.
RiosJJPariaNBurnsDKet al.Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly. Hum Mol Genet2013; 22: 444–451.
227.
SilvermanTAEnzingerFM. Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases. Am J Surg Pathol1985; 9: 7–14.
228.
BiscegliaMVigilanteEBen-DorD. Neural lipofibromatous hamartoma: a report of two cases and review of the literature. Adv Anat Pathol2007; 14: 46–52.
229.
RekhiBJambhekarNA. Morphologic spectrum, immunohistochemical analysis and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center. Ann Diagn Pathol2010; 14: 162–167.
230.
RawalYBDodsonTB. S-100 negative granular cell tumor (so-called primitive polypoid non-neural granular cell tumor) of the oral cavity. Head Neck Pathol2016; 11(3): 404–412.
231.
ChildersELBFanburg-SmithJC. Congenital epulis of the newborn: 10 new cases of a rare oral tumor. Ann Diagn Pathol2011; 15: 157–161.
HeJFLinYLiuJHLiZY. Solitary S-100-positive congenital granular cell tumor of the tongue: a case report and literature review. Ann Plast Surg2014; 72: 725–728.
234.
AlemayehuHPolitesSFKatsAIshitaniMBMoirCRIqbalCW. Granular cell tumors and congenital granular cell epulis in children: similar entities. J Pediatr Surg2015; 50: 775–778.
235.
ChamberlainBKMcClainCMGonzalezRSCoffinCMCatesJMM. Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study. Hum Pathol2014; 45: 1039–1044.
Perez-GonzalezYPaguraLLlamas-VelascoMCortes-LambeaLKutznerHRequenaL. Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature. Am J Dermatopathol2015; 37(4): 334–340.
238.
CoffinCMAlaggioR. Fibroblastic and myofibroblastic tumors in children and adolescents. Pediatr Dev Pathol2012; 15(1 Suppl): 127–180.
239.
BehamABadveSSusterSFletcherCD. Solitary myofibroma in adults: clinicopathological analysis of a series. Histopathology1993; 22: 335–341.
240.
OudijkLden BakkerMAHopWCJet al.Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases. Histopathology2012; 60: E1–E11.
241.
MartignettiJATianLLiDet al.Mutations in PDGFRB cause autosomal-dominant infantile by myofibromatosis. Am J Hum Genet2013; 92: 1001–1007.
AntonescuCRSungYSZhangLet al.Recurrent SRF-RELA fusions define a novel subset of cellular myofibroma/myopericytoma: a potential diagnostic pitfall with sarcomas with myogenic differentiation. Am J Surg Pathol2017; 41(5): 677–684.
244.
SaabSTMcClainCMCoffinCM. Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol2014; 38: 394–401.
245.
Al-IbraheemiAMartinezAWeissSWet al.Fibrous hamartoma of infancy: a clinicopathologic study of 145 cases, including 2 with sarcomatous features. Mod Pathol2017; 30: 474–485.
246.
MelnickLBergerEMElenitsasRChachkinSTreatJR. Fibrous hamartoma of infancy: a firm plaque presenting with hypertrichosis and hyperhidrosis. Pediatr Dermatol2015; 32: 533–535.
247.
MüllerCSPföhlerCCerroniLMeierCMVogtT. Fibrous hamartoma of infancy within a congenital nevus. J Dtsch Dermatol Ges2015; 13: 1282–1284.
248.
GrynspanDMeirKSengerCBallNJ. Cutaneous changes in fibrous hamartoma of infancy. J Cutan Pathol2007; 34: 39–43.
249.
ParkJYCohenCLopezDRamosEWagenfuehrJRakhejaD. EGFR Exon 20 insertion/duplication mutations characterize fibrous hamartoma of infancy. Am J Surg Pathol2016; 40: 1713–1718.
250.
LaskinWBMiettinenMFetschFJ. Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up. Am J Surg Pathol2009; 33: 1–13.
251.
MarksEEwartM. Infantile digital fibroma: a rare fibromatosis. Arch Pathol Lab Med2016; 140: 1153–1156.
252.
ThwayKGibsonSRamsayASebireNJ. Beta-catenin expression in pediatric fibroblastic and myofibroblastic lesions: a study of 100 cases. Pediatr Dev Pathol2009; 12: 292–296.
NiambaPLéauté-LabrèzeCBoraleviFet al.Further documentation of spontaneous regression of infantile digital fibromatosis. Pediatr Dermatol2007; 24: 280–284.
255.
BaykalCBuyukbabaniNYazganogluKDSaglikE. Acquired digital fibrokeratoma. Cutis2007; 79: 129–132.
256.
HwangSKimMChoBKParkHJ. Clinical characteristics of acquired ungual fibrokeratoma. Indian J Dermatol Venereol Leprol2016; 83(3): 337–343.
257.
AldrichSLHongCHGrovesLOlsenCMossJDarlingTN. Acral lesion in tuberous sclerosis complex: Insights into pathogenesis. J Am Acad Dermatol2010; 63: 244–251.
258.
JóźwiakSSchwartzRAJannigerCKMichalowiczRChmielikJ. Skin lesions in children with tuberous sclerosis complex: their prevalence, natural course, and diagnostic significance. Int J Dermatol1998; 37: 911–917.
259.
DrutRPedemonteLRosittoA. Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome. Int J Surg Pathol2005; 13: 181–184.
260.
IzadpanahAHogelingMBukaRLEichenfieldLFBirdLM. Digitocutaneous dysplasia. J Am Acad Dermatol2007; 56: 86–89.
261.
HollmannTJBovéeJVFletcherCD. Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases. Am J Surg Pathol2012; 36: 789–798.
262.
MentzelTDei TosAPSapiZKutznerH. Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol2006; 30: 104–113.
263.
LeBlancRETaubeJ. Myofibroma, myopericytoma, myoepithelioma and myofibroblastoma of skin and soft tissue. Surg Pathol Clin2011; 4: 745–759.
264.
DrayMSMcCarthySWPalmerAAet al.Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. J Clin Pathol2006; 59: 67–73.
265.
HallerFKnopfJAckermannAet al.Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol2016; 238: 700–710.
266.
FetschJFMiettinenMLaskinWBMichalMEnzingerFM. A clinicopathologic study of 45 pediatric soft tissue tumors with an admixture of adipose tissue and fibroblastic elements, and a proposal for classification as lipofibromatosis. Am J Surg Pathol2000; 24: 1491–1500.
267.
BoosMDChikwavaKRDormansJPChauvinNAJenM. Lipofibromatosis: an institutional and literature review of an uncommon entity. Pediatr Dermatol2014; 31: 298–304.
KumarEPatelNRDemiccoEGet al.Cutaneous nodular fasciitis with genetic analysis: a case series. J Cutan Pathol2016; 43: 1143–1149.
270.
ShinCLowINgDOeiPMilesCSymmansP. USP6 gene rearrangement in nodular fasciitis and histological mimics. Histopathology2016; 69: 784–791.
271.
de FeraudySFletcherCD. Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases. Am J Surg Pathol2010; 34: 1377–1381.
272.
MagroGMichalMAlaggioRD’AmoreE. Intradermal proliferative fasciitis in childhood: a potential diagnostic pitfall. J Cutan Pathol2011; 38: 59–62.
273.
BarakSWangZMiettinenM. Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall. Am J Surg Pathol2012; 36: 1404–1409.
274.
SouleEHPritchardDJ. Fibrosarcoma in infants and children a review of 110 cases. Cancer1997; 40: 1711.
275.
KnezevichSRMcFaddenDETaoWLimJFSorensenPH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet1998; 18: 184.
276.
EnosTHoslerGAUddinNMirA. Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature. J Cutan Pathol2017; 44: 193–200.
277.
de FeraudySFletcherCD. Fibroblastic connective tissue nevus: a rare cutaneous lesion analyzed in a series of 25 cases. Am J Surg Pathol2012; 36: 1509–1515.
278.
MentzelTKutznerH. Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol2009; 31: 44–49.
279.
ForcucciJABrunerETSmithMT. Benign soft tissue lesions that may mimic malignancy. Semin Diagn Pathol2016; 33: 50–59.
280.
WoodLFountaineTJRosamiliaLHelmKFClarkeLE. Cutaneous CD34+ spindle cell neoplasms: histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor and dermatofibrosarcoma protuberans. Am J Dermatopathol2010; 32: 764–768.
281.
TardioJC. CD34-reactive tumors of the skin. An updated review of an ever-growing list of lesions. J Cutan Pathol2009; 36: 89–102.
282.
CanelasMMCardosoJCAndradePFReisJPTellecheaO. Fibrous histiocytomas: histopathologic review of 95 cases. Am Bras Dermatol2010; 85: 211–215.
283.
LuzarBCalonjeE. Cutaneous fibrohistiocytic tumours – an update. Histopathology2010; 56: 148–165.
284.
ClarkeLE. Fibrious and fibrohistiocytic neoplasms: an update. Dermatol Clin2012; 30: 643–656.
285.
MentzelT. Cutaneous mesenchymal tumours: an update. Pathology2014; 46: 149–159.
286.
FinchJBerkeAMcCuskerMChangMW. Congenital multiple clustered dermatofibroma in a 12-year-old girl. Pediatr Dermatol2014; 31: 105–117.
287.
HondaMTomimuraSde VegaSUtaniA. Multiple dermatofibromas in a patient with Down syndrome. J Dermatol2016; 43: 346–348.
288.
Pinto-AlmeidaTCaetanoMAlvesRSeloresM. Congenital multiople clustered dermatofibroma and multiple eruptive dermatofibromas – unusual presentations of a common entity. An Bras Dermatol2013; 88(Suppl 1): 563–566.
289.
AlvesJVMatosDMBarreirosHFBártoloEA. Variants of dermatofibroma – a histopathological study. An Bras Dermatol2014; 89: 472–477.
290.
ZelgerBGSidoroffAZelgerB. Combined dermatofibroma: co-existence of two or more variant patterns in a single lesion. Histopathology2000; 36: 529–539.
291.
DehnerLP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol2003; 27: 579–593.
292.
GleasonBCFletcherCD. Deep “benign” fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential. Am J Surg Pathol2008; 32: 354–362.
293.
SandellRFCarterJMFolpeAL. Solitary (juvenile) xanthogranuloma: a comprehensive immunohistochemical study emphasizing recently developed markers of histiocytic lineage. Hum Pathol2015; 46: 1390–1397.
294.
PouryazdanparastPYuLCutlanJEOlsenSHFullenDRMaL. Diagnostic value of CD163 in cutaneous spindle cell lesions. J Cutan Pathol2009; 36: 859–864.
295.
DoyleLAFletcherCD. Metastasizing “benign” cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol2013; 37(4): 484–495.
296.
KadduSMcMenaminMFletcherCD. Atypical Fibrous Histiocytoma of the Skin: Clinicopathologic Analysis of 59 Cases With Evidence of Infrequent Metastasis. Am J Surg Pathol2002; 26: 35–46.
297.
VolpicelliERFletcherCD. Desmin and CD34 positivity in cellular fibrous histiocytoma: an immunohistochemical analysis of 100 cases. J Cutan Pathol2012; 39(8): 747–752.
298.
HorensteinMGPrietoVGNuckolsJDBurchetteJLSheaCR. Indeterminate fibrohistiocytic lesions of the skin: is there a spectrum between dermatofibroma and dermatofibrosarcoma protuberans?Am J Surg Pathol2000; 24(7): 996–1003.
299.
DoyleLAMariño-EnriquezAFletcherCDHornickJL. ALK rearrangement and overexpression in epithelioid fibrous histiocytoma. Mod Pathol2015; 28(7): 904–912.
300.
FraterJLMaddoxJSObadiahJMHurleyMY. Cutaneous Rosai-Dorfman disease: comprehensive review of cases reported in the medical literature since 1990 and presentation of an illustrative case. J Cutan Med Surg2006; 10: 281–290.
301.
MoosaviCJhaPFanbury-SmithJC. An update on plexiform fibrohistiocytic tumor and addition of 66 new cases from the Armed Forces Institute of Pathology, in honor of Franz M. Enzinger, MD. Ann Diagn Pathol2007; 11: 313–319.
302.
Jacobson-DunlopEWhiteCRJrMansoorA. Features of plexiform fibrohistiocytic tumor in skin punch biopsies: a retrospective study of 6 cases. Am J Dermatopathol2011; 33: 551–556.
303.
FoxMDBillingsSDGleasonBCet al.Expression of MiTF may be helpful in differentiating cellular neurothekeoma from plexiform fibrohistiocytic tumor (histiocytoid predominant) in a partial biopsy specimen. Am J Dermatopathol2012; 34: 157–160.
304.
WangGYNazarianRMZhaoLet al.Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic and melanocytic lesions: comparison with cellular neurothekeoma. Pathology2017; 49: 44–49.
VargasSOPerez-AtaydeARGonzalez-CrussiFKozakewichHP. Giant cell angioblastoma: three additional occurrences of a distinct pathologic entity. Am J Surg Pathol2001; 25: 185–196.
307.
JhaPMoosaviCFanburg-SmithJC. Giant cell fibroblastoma: an update and addition of 86 new cases from the Armed Forces Institute of Pathology, in honor of Dr. Franz M. Enzinger. Ann Diagn Pathol2007; 11: 81–88.
308.
ThwayKNoujaimJJonesRLFisherC. Dermatofibrosarcoma protuberans: pathology, genetics and potential therapeutic strategies. Ann Diagn Pathol2016; 25: 64–71.
309.
KuzelPMetelitsaAIDoverDCSalopekTG. Epidemiology of dermatofibrosarcoma protuberans in Alberta, Canada, from 1988 to 2007. Dermatol Surg2012; 38: 1461–1468.
310.
HanHHLimSYParkYMRhieJW. Congenital dermatofibrosarcoma protuberans: a case report and literature review. Ann Dermatol2015; 27: 597–600.
311.
RubioGAAlvaradoAGerthDJTashiroJThallerSR. Incidence and outcomes of dermatofibrosarcoma protuberans in the US pediatric population. J Craniofac Surg2017; 28: 182–184.
312.
LlombartBSerra-GuillenCMonteagudoCGuerreroJALSanmartinO. Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management. Semin Diagn Pathol2013; 30: 13–28.
MentzelTBehamAKatenkampDDei TosAPFletcherCD. Fibrosarcomatous (“high-grade”) dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance. Am J Surg Pathol1998; 22(5): 576–587.
315.
MorimitsuYHisaokaMOkamotoSHashimotoHUshijimaM. Dermatofibrosarcoma protuberans and its fibrosarcomatous variant with areas of myoid differentiation: a report of three cases. Histopathology1998; 32(6): 547–551.
316.
KesserwanCSokolicRCohenEWet al.Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase–deficient severe combined immune deficiency. J Allergy Clin Immunol2012 Mar; 129(3): 762–769.
317.
ThwayKNgWNoujaimJJonesRLFisherC. The current status of solitary fibrous tumor: diagnostic features, variants and genetics. Int J Surg Pathol2016; 24: 281–292.
318.
BarthelmebSGeddertHBoltzeCet al.Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol2014; 184: 1209–1218.
319.
HardissonDCuevas-SantosJContrerasF. Solitary fibrous tumor of the skin. J Am Acad Dermatol2002; 46(2 Suppl): S34–S40.
320.
RizkTAwadaASebaalyAHouraniR. Solitary fibrous tumor of the scalp in a child. J Neurosurg Pediatr2013; 11: 79–81.
321.
MutgiKAJChitgopekerPCilibertoHStoneMS. Hypocellular plaque-like CD34-positive dermal fibroma (medallion-like dermal dendrocyte hamartoma) presenting as a skin-colored dermal nodule. Pediatr Dermatol2016; 33: e16–e19.
KutznerHMentzelTPalmedoGet al.Plaque-like CD34-positive dermal fibroma (“medallion-like dermal dendrocyte hamartoma”): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans. Am J Surg Pathol2010; 34: 190–201.
324.
CheonMJungKEKimHSet al.Medallion-like dermal dendrocyte hamartoma: differential diagnosis with congenital atrophic dermatofibrosarcoma protuberans. Ann Dermatol2013; 25: 382–384.
325.
Keppler-NoreuilKMRiosJJParkerVERet al.PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis and evaluation. Am J Med Genet A2015; 167A: 287–295.
326.
BoybeyiOAlanayYKayikciogluAKarnakI. Hemihyperplasia-multiple lipomatosis syndrome: an underdiagnosed entity in children with asymmetric overgrowth. J Pediatr Surg2010; 45: E19–E23.
327.
GucevZSTasicVJancevskaAet al.Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome: CNS malformations and seizures may be a component of this disorder. Am J Med Genet A2008; 146A: 2688–2690.
328.
CraiglowBGKoCJAntayaRJ. Two cases of hemihyperplasia-multiple lipomatosis syndrome and review of asymmetric hemihyperplasia syndromes. Pediatr Dermatol2014; 31: 507–510.
329.
BeachkofskyTMSappJCBieseckerLGDarlingTN. Progressive overgrowth of the cerebriform connective tissue nevus in patients with Proteus syndrome. J Am Acad Dermatol2010; 63: 799–804.
330.
TalamancaLFVerdolottiTColafatiGSBernadiB. Hemimegalencephaly associated with congenital infiltrating lipomatosis of the face: a case report. Neuropediatrics2012; 43: 349–352.
SerpaMSScullyCMolina VivasAPde AlmeidaOPCostaFDAlvesFA. Infiltrating lipomatosis of the face: case series and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol2017; 123: e99–e105.
333.
BieserSReisMGuzmanMet al.Grade II pilocytic astrocytoma in a 3-month-old patient with encephalocraniocutaneous lipomatosis [ECCL]: case report and literature review of low grade gliomas in ECCL. Am J Med Genet Part A2015; 167A: 878–881.
334.
RuggieriMPraticoAD. Mosaic Neurocutaneous disorders and their causes. Semin Pediatr Neurol2015; 22: 207–233.
335.
BoppudiSBogershausenNHoveHBet al.Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis. Clin Genet2016; 90: 334–342.
336.
BennettJTTanTYAlcantaraDet al.Mosaic activating mutations in FGFR1 cause encephalocraniocutaneous lipomatosis. Am J Hum Genet2016; 98: 579–587.
337.
KurekKCHowardETennantLBet al.PTEN hamartoma of soft tissue: a distinctive lesion in PTEN syndromes. Am J Surg Pathol2012; 36: 671–687.
338.
CoffinCMAlaggioR. Adipose and myxoid tumors of childhood and adolescence. Pediatr Dev Pathol2012; 15(Suppl 1): 239–254.
339.
Pierre-KahnAZerahMRenierDet al.Congenital lumbosacral lipomas. Childs Nerv Syst1997; 13: 298–334.
340.
MorotaNIharaSOgiwaraH. New classification of spinal lipomas based on embryonic stage. J Neurosurg Pediatr2017; 19: 428–439.
341.
CoffinCMLowichikAPutnamA. Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol2009; 33: 1705–1712.
342.
MiettinenMFetschJF. Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol2006; 30: 521–528.
343.
WarrenMTurpinBKMarkMSmolarekTALiY. Undifferentiated myxoid lipoblastoma with PLAG1-HAS2 fusion in an infant; morphologically mimicking primitive myxoid mesenchymal tumor of infancy (PMMTI)–diagnostic importance of cytogenetic and molecular testing and literature review. Cancer Genet2016; 209: 21–29.
344.
DadoneBRefaeSLemarie-DelaunayCBianchiniLPedeutourF. Molecular cytogenetics of pediatric adipocytic tumors. Cancer Genet2015; 208: 469–481.
345.
YoshidaHMiyachiMOuchiKet al.Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma. Genes Chromosomes Cancer2014; 53: 606–611.
346.
KimHJYangIJungAYHwangJHShinMK. Angiomyxolipoma (vascular myxolipoma) of the knee in a 9-year-old boy. Pediatr Radiol2010; 40(Suppl 1): S30–S33.
347.
Martinez-MataGRocioMFJuanLEPaesAOAdalbertoMT. Angiomyxolipoma (vascular myxolipoma) of the oral cavity. Report of a case and review of the literature. Head Neck Pathol2011; 5: 184–187.
348.
PontesHAPontesFSCruz e SilvaBTet al.Angiomyolipomatous hamartoma of the upper lip: a rare case in an 8-month-old child and differential diagnosis. J Craniomaxillofac Surg2011; 39: 102–106.
349.
MartiNJordaEMontegudaCGamezLReigICalduchL. Multiple cutaneous angiomyxomas in a child. Pediatr Dermatol2011; 28: 462–464.
350.
BahetiADTirumaniSHRosenthalMHet al.Myxoid soft-tissue neoplasms: comprehensive update of taxonomy and MRI features. AJR2015; 204: 374–385.
351.
MurphyCMGrau-MassanesMSanchezRL. Multiple cutaneous myxomas. Report of a case without other elements of Carney’s complex. J Cutan Pathol1995; 22: 556–562.
352.
CalonjeEGuerinDMcCormickDFletcherCD. Superficial angiomyxoma: clinicopathologic analysis of a series of distinctive but poorly recognized cutaneous tumors with tendency for recurrence. Am J Surg Pathol1999; 23(8): 910–917.
353.
AllenPWDymockRBMacCormacLB. Superficial angiomyxomas with and without epithelial components. Report of 30 tumors in 28 patients. Am J Surg Pathol1988; 12(7): 519–530.
354.
PattJCHainesN. Soft tissues sarcomas in skin: presentations and management. Semin Oncol2016; 43: 413–418.
355.
RouhaniPFletcherCDMDevesaSSToroJR. Cutaneous soft tissue sarcoma incidence patterns in the U.S.: an analysis of 12,114 cases. Cancer2008; 113: 616–627.
356.
SenerchiaAARibeiroKBRodriguez-GalindoC. Trends in incidence of primary cutaneous malignancies in children, adolescents and young adults: a population-based study. Pediatr Blood Cancer2014; 61: 211–216.
357.
ByunMMaCSAkcayAet al.Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med2013; 210: 1743–1759.
358.
JacksonCCDicksonMASadjadiMet al.Kaposi sarcoma of childhood: inborn or acquired immunodeficiency to oncogenic HHV-8. Pediatr Blood Cancer2016; 63: 392–397.
359.
ReesCAKeatingEMLukolyoHet al.Mapping the epidemiology of Kaposi sarcoma and non-Hodgkin lymphoma among children in Sub-Saharan Africa: a review. Pediatr Blood Cancer2016; 63: 1325–1331.
360.
DeyrupATLeeVKHillCEet al.Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol2006; 30: 75–82.
361.
TetzlaffMTNosekCKovarikC. Epstein-Barr virus-associated leiomyosarcoma with cutaneous involvement in an African child with human immunodeficiency virus: a case report and review of the literature. J Cutan Pathol2011; 38: 731–739.
362.
RamdialPKSingYDeonarainJHadleyGPSinghB. Dermal Epstein-Barr virus-associated leiomyosarcoma: tocsin of acquired immunodeficiency syndrome in two children. Am J Dermatopathol2011; 33: 392–396.
363.
WinchesterDSHockerTLBrewerJDet al.Leiomyosarcoma of the skin: clinical, histopathologic and prognostic factors that influence outcomes. J Am Acad Dermatol2014; 71: 919–925.
364.
FauthCTBruecksAKTempleWArletteJPDiFrancescoLM. Superficial leiomyosarcoma: a clinicopathologic review and update. J Cutan Pathol2010; 37: 269–276.
365.
Aneiros-FernandezJAntonio RetameroJHusein-ElahmedHOvalleFAneiros-CachazaJ. Primary cutaneous and subcutaneous leiomyosarcomas: evolution and prognostic factors. Eur J Dermatol2016; 26: 9–12.
366.
SchmidtCSBentzML. Congenital smooth muscle hamartoma: the importance of differentiation from melanocytic nevi. J Craniofac Surg2005; 16: 926–929.
367.
JanickECNazarethMRRothmanIL. Generalized smooth muscle hamartoma with multiple congenital anomalies without the “Michelin tire baby” phenotype. Pediatr Dermatol2014; 31: 731–733.
368.
de la Luz Orozco-CovarrubiasMTamayo-SanchezLDuran-McKinsterCRidauraCRuiz-MaldonadoR. Malignant cutaneous tumors in children. Twenty years of experience at a large pediatric hospital. J Am Acad Dermatol1994; 30(2 Pt 1): 243–249.
369.
WescheWAKhareVKChesneyTMJenkinsJJ. Non-hematopoietic cutaneous metastases in children and adolescents: thirty years experience at St. Jude Children’s Research Hospital. J Cutan Pathol2000; 27: 485–492.
370.
IsaacsHJr. Cutaneous metastases in neonates: a review. Pediatr Dermatol2011; 28: 85–93.
371.
MarburgerTBGardnerJMPrietoVGBillingsSD. Primary cutaneous rhabdomyosarcoma: a clinicopathologic review of 11 cases. J Cutan Pathol2012; 39: 987–995.
372.
FeaselPCMarburgerTBBillingsSD. Primary cutaneous epithelioid rhabdomyosarcoma: a rare, recently described entity with review of the literature. J Cutan Pathol2014; 41: 588–591.
373.
TariASAmoliFARajabiMTEsfahaniMRRahimiA. Cutaneous embryonal rhabdomyosarcoma presenting as a nodule on cheek; a case report and review of literature. Orbit2006; 25: 235–238.
374.
ChangYDehnerLPEgbertB. Primary cutaneous rhabdomyosarcoma. Am J Surg Pathol1990; 14: 977–982.
375.
HoangMPSinkrePAlbores-SaavedraJ. Rhabdomyosarcoma arising in a congenital melanocytic nevus. Am J Dermatopathol2002; 24: 26–29.
376.
ShahgholiEMollaianMHaghshenasZHonarmandM. Congenital rhabdomyosarcoma, central precocious puberty, hemihypertrophy and hypophosphatemic rickets associated with epidermal nevus syndrome. J Pediatr Endocrino Metab2011; 24: 1063–1066.
377.
LimaLLRodriguesCAPereiraPMSchettiniAPTupinambaWL. Primary cutaneous alveolar rhabdomyosarcoma in a pediatric patient. An Bras Dermatol2011; 86: 363–365.
378.
SamborskaMDerwichKSkalska-SadowskaJKurzawaPWachowiakJ. Myeloid sarcoma in children – diagnostic and therapeutic difficulties. Contemp Oncol (Pozn)2016; 20: 444–448.
379.
BainEERothmanILinL. De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. J Cutan Pathol2013; 40: 321–325.
380.
WangHQLiJ. Clinicopathological features of myeloid sarcoma: report of 39 cases and literature review. Pathol Res Pract2016; 212: 817–824.
381.
HsuehCKuoTT. Congenital malignant rhabdoid tumor presenting as a cutaneous nodule: report of 2 cases with review of the literature. Arch Pathol Lab Med1998; 122: 1099–1102.
382.
CobbARSebireNJAndersonJDunawayD. Congenital malignant rhabdoid tumor of the scalp. J Craniomaxillofac Surg2012; 40: e258–e260.
383.
HollmannTJHornickJL. INI1-deficient tumors: diagnostic features and molecular genetics. Am J Surg Pathol2011; 35: e47–e63.
384.
JawadMUExteinJMinESScullySP. Prognostic factors for survival in patients with epithelioid sarcoma. Clin Orthop Relat Res2009; 467: 2939–2948.
385.
ThwayKJonesRLNoujaimJFisherC. Epithelioid sarcoma: diagnostic features and genetics. Adv Anat Pathol2016; 23: 41–49.
386.
AsanoNYoshidaAOguraKet al.Prognostic value of relevant clinicopathologic variables in epithelioid sarcoma: a multi-institutional retrospective study of 44 patients. Ann Surg Oncol2015; 22(8): 2624–2632.
387.
MiettinenMFanburg-SmithJCVirolainenMShmooklerBMFetschJF. Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis. Hum Pathol1999; 30: 934–942.
388.
Terrier-LacombeMJGuillouLChibonFet al.Superficial primitive Ewing’s sarcoma: a clinicopathologic and molecular cytogenetic analysis of 14 cases. Mod Pathol2009; 22: 87–94.
389.
YusteVSierraERuanoDLlamas-VelascoMCondeEAzorinD. Primary cutaneous Ewing sarcoma: report of a case. Fetal Pediatr Pathol2015; 34: 315–321.
390.
Di GiannataleAFrezzaAMLe DeleyMCet al.Primary cutaneous and subcutaneous Ewing sarcoma. Pediatr Blood Cancer2015; 62: 1555–1561.
TolkachjovSNSchmittARMuzicJGWeaverALBaumCL. Incidence and clinical features of rare cutaneous malignancies in Olmsted County, Minnesota. 2000 to 2010. Dermatol Surg2017; 43: 116–124.
395.
MillerKGoodladJRBrennT. Pleomorphic dermal sarcoma: adverse histologic features predict aggressive behavior and allow distinction from atypical fibroxanthoma. Am J Surg Pathol2012; 36: 1317–1326.
396.
KraemerKHDiGiovannaJJXeroderma pigmentosum. In: PagonRAAdamMPArdingerHHet al.(eds). GeneReview® [Internet], Seattle, WA: University of Washington, Seattle, 2003.
397.
ShaoLNewellBQuintanillaN. Atypical fibroxanthoma and squamous cell carcinoma of the conjunctiva in xeroderma pigmentosum. Pediatr Dev Pathol2007; 10: 149–152.
398.
ChappellAGChaseEPChangBet al.Atypical fibroxanthoma in a 13-year-old Guatemalan girl with xeroderma pigmentosum. Pediatr Dermatol2016; 33: e228–e229.
399.
JoVY. Myoepithelial tumors: an update. Surg Pathol Clin2015; 8: 445–466.
400.
JoVYFletcherCD. Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features. Head Neck Pathol2015; 9(1): 32–38.
401.
LawRMViglioneMPBarrettTL. Metastatic myoepithelial carcinoma in a child. J Cutan Pathol2008; 35(8): 779–781.
402.
RekhiBKosemehmetogluKTezelGGDervisogluS. Clinicopathologic features and immunohistochemical spectrum of 11 cases of epithelioid malignant peripheral nerve sheath tumors, including INI1/SMARCB1 results and BRAF V600E analysis. APMIS2017; 125(8): 679–689.
