The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 9 vanilla-derived ingredients as used in cosmetics. These ingredients are reported to function mostly as skin conditioning agents in cosmetic products. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents, and to avoid reaching levels that may be hazardous to consumers. Industry should continue to use good manufacturing practices to limit impurities. The Panel reviewed data relating to the safety of these ingredients and concluded that 7 ingredients are safe in cosmetics in the present practices of use and concentration when formulated to be non-sensitizing. The Panel further concluded that the available data are insufficient to make a determination of safety under the intended conditions of use in cosmetic formulations for Vanilla Planifolia Flower Extract and Vanilla Planifolia Leaf Cell Extract.
BrunschwigCCollardFLepers-AndrzejewskiSRaharivelomananaP. Tahitian vanilla (Vanilla x tahitensis): a vanilla species with unique features. University of French Polynesia. In: El-ShemyH, ed. Active Ingredients from Aromatic and Medicinal Plants; 2017:29-47.
6.
BrunschwigCRochardSPierratA, et al.Volatile composition and sensory properties of Vanilla × tahitensis bring new insights for vanilla quality control. J Sci Food Agric. 2016;96(3):848-858.
7.
Anonymous. Vanilla planifolia fruit extract - summary information from one supplier. Unpublished data submitted by the Personal Care Products Council on May 15, 2019; 2019.
BrunschwigCSenger-EmonnotPAubanelM, et al.Odor-active compounds of Tahitian vanilla flavor. Food Res Int. 2012;46(1):148-157.
10.
CEP-Solabia Group. Manufacturing process vanirea UP (propylene glycol, water, and Vanilla tahitensis fruit extract). Unpublished data submitted by the Personal Care Products Council on 3-5-2019.
11.
CEP-Solabia Group. Manufacturing process vanirea BG UP (butylene glycol, water, and Vanilla tahitensis fruit exctract). Unpublished data submitted by the Personal Care Products Council on 3-5-2019; 2009.
12.
NaiduMKumarPVSShyamalaBSulochanammaGPrakashMThakurM. Enzyme-assisted process for production of superior quality vanilla extracts from green vanilla pods using tea leaf enzymes. Food Bioprocess Technol. 2012;5(2):527-532.
CEP-Solabia Group. Ingredient breakdown vanirea UP (propylene glycol, water, and Vanilla tahitensis fruit extract). Unpublished Data Submitted by the Personal Care Products Council on 3-5-2019; 2009.
15.
CEP-Solabia Group. Ingredient breakdown Vanirea BG UP (butylene glycol, water, and Vanilla tahitensis fruit extract). Unpublished data submitted by the Personal Care Products Council on 3-5-2019; 2009.
16.
RanadiveA. Vanillin and related flavor compounds in vanilla extracts made from beans of various global origins. J Agric Food Chem. 1992;40(10):1922-1924.
17.
ShigetoAHachisukaSKumazawaK. Characterization of potent odorants in three different cultivars (Madagascar, Comoro and Tahiti) of vanilla bean by aroma extract dilution analysis (AEDA). Food Sci Technol Res. 2016;22(6):811-816.
18.
DignumMvan der HeijdenRKerlerJWinkelCVerpoorteR. Identification of glucosides in green beans of Vanilla planifolia Andrews and kinetics of vanilla β-glucosidase. Food Chem. 2004;85(2):199-205.
19.
LiangHLuJDaiYLiXGuoSLiQ. Analysis of the volatile components of the fruits of vanilla planifolia Andrews by HS-SPME combined with GC-MS. Med Plants. 2014;5(4):23-26.
20.
StahlWVoelkerWSullivanJ. Analysis of vanilla extracts. IV. Amino acid determination. J AOAC Int. 1962;45:108-113.
21.
DaCostaNCMeilCPantiniM. The analysis of volatiles in Tahitian vanilla (Vanilla tahitensis) including novel compounds. Dev Food Sci. 2006;43:161-164.
22.
EhlersDPfisterMBartholomaeS. Analysis of Tahiti vanilla by high-performance liquid chromatography. Z Lebensm Unters Forch. 1994;199(1, July):38-42.
23.
Ramaroson-RaonizafinimananaBGaydouEBombardaI. Hydrocarbons from three vanilla bean species: V. fragrans, V. madagascariensis, and V. tahitensis. J Agric Food Chem. 1997;45(7):2542-2545.
24.
Ramaroson-RaonizafinimananaBGaydouEBombardaI. Long-chain aliphatic beta-diketones from epicuticular wax of Vanilla bean species. Synthesis of nervonoylacetone. J Agric Food Chem. 2000;48(10):4739-4743.
25.
Ramaroson-RaonizafinimananaBGaydouEBombardaI. 4-Demethylsterrols and triterpene alcohols from two vanilla bean species: Vanilla fragrans and V. tahitensis. JAOCS (J Am Oil Chem Soc). 1998;75(1):51.
26.
GassenmeierKBinggeliE. Vanilla bean quality - a flavor industry view. In Expression of Multidisciplinary Flavour Science, Proceedings of the Weurman Symposium, Interlaken, Switzerland, 2010(12th):203-206.
27.
HondrogiannisERottaKZapfC. The use of wavelength dispersive X-ray fluorescence in the identification of the elemental composition of vanilla samples and the determination of the geographic origin by discriminant function analysis. J Food Sci. 2013;78(3):395-401.
28.
The research insitute for fragrance materials (RIFM). Pure vanilla extract1-fold E.O.A. 71-87. Unpublished data submission to RIFM. 1971:1-2.
29.
PalamaTFockIChoiYVerpoorteRKodjaH. Biological variation of Vanilla planifolia leaf metabolome. Phytochemistry. 2010;71(5-6):567-573.
30.
MatsubaraSHeinD. Sun-shade patterns of leaf carotenoid composition in 86 species of neotrropical forest plants. Funct Plant Biol. 2009;36(1):20-36.
31.
ChenFTobimatsuYHavkin-FrenkelDDixonRARalphJ. A polymer of caffeyl alcohol in plant seeds. Proc Natl Acad Sci U S A. 2012;109(5):1772-1777.
32.
BhatABhadramurthyVSijuSHareeshP. Detection and identification of Cymbidium mosaic virus infecting Vanilla (Vanilla planifolia Andrews) in India based on coat protein gene sequence relatioinships. J Plant Biochem Biotechnol. 2006;15(1):33-37.
33.
MadhubalaRBhadramurthyVBhatAIHareeshPRetheeshSBhaiR. Occurrence of cucumber mosaic virus on vanilla (Vanilla planifolia Andrews) in India. J Biosci. 2005;30(3):339-350.
34.
U.S. Food and Drug Administration Center for Food Safety & Applied Nutrition (CFSAN). Voluntary cosmetic registration program - frequency of use of cosmetic ingredients. College Park, MD. Obtained under the Freedom of Information Act from CFSAN; requested as “Frequency of Use Data” January 6, 2020; received January 13, 2020; 2020.
35.
Personal Care Products Council. Concentration of use by FDA product category: vanilla-derived ingredients. Unpublished data submitted by the Personal Care Products Council on 12-13-2017.
36.
RotheHFautzRGerberE, et al.Special aspects of cosmetic spray safety evaluations: principles on inhalation risk assessment. Toxicol Lett. 2011;205(2):97-104.
37.
BremmerHJPrud'homme de LodderLCHEngelenJGM. Cosmetics Fact Sheet: to assess the risks for the consumer. Updated version for ConsExpo 4. 20200. Report No. RIVM 320104001/2006. https://www.rivm.nl/bibliotheek/rapporten/320104001.pdf. Accessed February 18, 2019.
38.
RotheH. Special aspects of cosmetic spray evaluation. Unpublished information presented to the 26 September Expert Panel. Washington D.C; 2011.
AylottRIByrneGAMiddletonJRobertsME. Normal use levels of respirable cosmetic talc: preliminary study. Int J Cosmet Sci. 1979;1(3):177-186.
41.
RussellRSMerzRDShermanWTSivertsonJN. The determination of respirable particles in talcum powder. Food Cosmet Toxicol. 1979;17(2):117-122.
42.
CIR Science and Support Committee of the Personal Care Products Council (CIR SSC). 11-3-2015. Cosmetic powder exposure. Unpublished data submitted by the Personal Care Products Council.
CEP-Solabia Group. Summary of ames assay vanirea BG UP (butylene glycol, water, and Vanilla tahitensis fruit extract). Unpublished data submitted by the Personal Care Products Council on 3-5-2019; 2007.
45.
CEP-Solabia Group. Summary of safety studies vanirea UP (propylene glycol, water, and Vanilla tahitensis fruit extract). Unpublished data submitted by the Personal Care Products Council on 3-5-2019; 2002.
46.
KligmanA. The contact-sensitization potential of fragrance materials by maximization testing in humans. Unpublished Report 1804 to the Research Institute for Fragrance Materials (RIFM); 1972. p. 1-3.
47.
Anonymous. Summary of an HRIPT on a leave-on product containing 0.02% vanilla planifolia fruit extract. Unpublished data submitted by the Personal Care Products Council on 8-27-2019; 2019.
48.
HjorthN. Eczematous allergy to balsams. Acta Derm Venereol. 1961;41(46):129-133.
49.
SpencerLVFowlerJFJ. Thin mint cookie dermatitis. Contact Dermat. 1988;18(3):185-186.
50.
CorresLFDDiezJAudicanaM, et al.Photodermatitis from plant derivatives in topical and oral medicaments. Contact Dermat. 1996;35(3):184-185.
51.
FergusonJBeckM. Contact sensitivity to vanilla in a lip salve. Contact Dermat. 1995;33(5):352.
52.
SchemanAGuptaS. Photoallergic contact dermatitis from diallyl disulfide. Contact Dermat. 2001;45(3):179.
