The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as used in cosmetic formulations. These ingredients are reported to function as an antioxidant and a light stabilizer, respectively. The Panel considered the available data and concluded that Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate are safe in cosmetics in the present practices of use and concentration described in this safety assessment.
FiumeMMHeldrethBABergfeldWF, et al.Safety assessment of citric acid, inorganic citrate salts, and alkyl citrate esters as used in cosmetics. Int J Toxicol. 2014;33(2 suppl):16S-46S.
CiriminnaRPagliaroM. Industrial oxidations with organocatalyst TEMPO and its derivatives. Org Process Res Dev. 2010;14(1):245-251.
6.
U.S. Food and Drug Administration (FDA). U.S. Food and Drug Administration Center for Food Safety & Applied Nutrition (CFSAN). Voluntary cosmetic registration program - frequency of use of cosmetic ingredients. (Obtained under the Freedom of Information Act from CFSAN; requested as “Frequency of Use Data”). 2021.
7.
Personal Care Products Council. Corrected concentration of use by FDA product category: hydroxy tetramethylpiperidine oxide. (Unpublished data submitted by the Personal Care Products Council on December 15, 2020). 2020.
8.
Personal Care Products Council. Concentration of use by FDA product category: tris(tetramethylhydroxypiperidinol) citrate. (Unpublished data submitted by Personal Care Products Council on June 1, 2018.). 2018.
9.
JohnsenMA. The influence of particle size. Spray Technol Mark. 2004;14(11):24-27.
10.
RotheH. Special Aspects of Cosmetic Spray Safety Evaluations: Principles on Inhalation Risk Assessment. Washington DC; 2011. (Unpublished data presented at the 26 September Expert Panel meeting).
11.
BremmerHJPrud’homme de LodderLCHvan EngelenJGM. Cosmetics Fact Sheet: To Assess the Risks for the Consumer; Updated Version for ConsExpo 4. Bilthoven, Netherlands: Netherlands National Institute for Public Health and the Environment; 2006. https://www.rivm.nl/bibliotheek/rapporten/320104001.pdf (Accessed August 24).
12.
RotheHFautzRGerberE, et al.Special aspects of cosmetic spray safety evaluations: principles on inhalation risk assessment. Toxicol Lett. 2011;205(2):97-104.
