The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 8 glycerin ethoxylates, as used in cosmetic formulations. All of these ingredients are reported to function in cosmetics as skin-conditioning agents, and most are also reported to function as viscosity-decreasing agents. The Panel reviewed relevant data relating to the safety of these ingredients. The Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration as described in this safety assessment when formulated to be non-irritating.
FiumeMMHeldrethBBergfeldWF, et al.Safety assessment of alkyl PEG ethers as used in cosmetics. Int J Toxicol. 2012;31(Suppl 5):169s-244s.
5.
BoyerIBurnettCLBergfeldWF, et al.Safety assessment of PEGs cocamine and related ingredients as used in cosmetics. Int J Toxicol. 2018;37(2_suppl):10s-60s.
Anonymous. Certificate of analysis: glycereth-26. 2019. (Unpublished data submitted by the Personal Care Products Council on June 11, 2019).
12.
HintonC, ed. The Chemistry and Manufacture of Cosmetics. Vol. III - Ingredients. Carol Stream, IL: Allured Publishing Company; 2002.
13.
U.S.Food and Drug Administration (FDA). U.S. Food and Drug Administration Center for Food Safety & Applied Nutrition (CFSAN). Voluntary Cosmetic Registration Program - frequency of use of cosmetic ingredients. 2020. (Obtained under the freedom of information act from CFSAN; requested as “frequency of use data”. January 6, 2020; received January 13, 2020).
14.
Personal Care Products Council. Updated concentration of use information: glycerin Ethoxylate. 2019. (Unpublished data submitted by Personal Care Products Council on May 9, 2019).
15.
JohnsenMA. The influence of particle size. Spray Technol Mark. 2004;14(11):24-27.
16.
RotheHFautzRGerberE, et al.Special aspects of cosmetic spray safety evaluations: principles on inhalation risk assessment. Toxicol Lett. 2011;205(2):97-104.
17.
BremmerHJPrud’homme de LodderLCHvan EngelenJGM. Cosmetics Fact Sheet: To Assess the Risks for the Consumer; Updated Version for ConsExpo 4. Bilthoven, Netherlands: Netherlands National Institute for Public Health and the Environment; 2006:1-77. RIVM 320104001/2006. https://www.rivm.nl/bibliotheek/rapporten/320104000.pdf. Accessed August 24, 2011.
Anonymous. Safety testing summary: Glycereth-26. 2019. (Unpublished data submitted by the Personal Care Products Council on June 11, 2019).
20.
Anonymous. Summary of HRIPT on leave-on products (containing 0.68% Glycereth-7 and 3% Glycereth-26). 2019. (Unpublished data submitted by the Personal Care Products Council on August 27, 2019).
21.
Anonymous. Summaries of Two HRIPTs (one product containing 2% Glycereth-7, one product containing 1% Glycereth-7). 2019. (Unpublished data submitted by the Personal Care Products Council on November 19, 2019).
22.
Personal Care Products Council. Glycerin ethoxylates: clarification and individual data for HRIPT study summaries with PCPC memos 7 and 8. 2020. (Details and explanations for previously submitted data provided by the Personal Care Products Council on July 28, 2020).
23.
AMA Laboratories I. Summary of results: 100 human subject repeat insult patch test skin irritation/sensitization evaluation (occlusive patch) product containing 0.35% Glycereth-12. 2014. (Unpublished data submitted by the Personal Care Products Council on December 19, 2019).
24.
Anonymous. Summaries of Two HRIPTs (both products contain 3% Glycereth-26). 2019. (Unpublished data submitted by the Personal Care Products Council on November 19, 2019).
25.
KGL, Inc. An evaluation of the contact-sensitization potential of a topical coded product in human skin by means of the maximizaiton assay (product contains 3% Glycereth-26). 2007. (Unpublished data submitted by the Personal Care Products Council on July 13, 2020).
26.
Consumer Product Testing Co. Individual results: repeated insult patch test/product containing 5% Glycereth-26. 2016. (Unpublished data submitted by the Personal Care Products Council on December 19, 2019).
27.
Anonymous. Determination of the irritating and sensitizing propensities of 685310 5 on human skin. 2005. (Unpublished data submitted by the Personal Care Product Council on July 21, 2020).
28.
Food and Drug Research Laboratories Incorporated. Repeated insult patch test: Glycereth-26 (10% aqueous solution tested). 1973. (Unpublished data submitted by the Personal Care Products Council on January 16, 2020).
29.
Anonymous. Summary information: safety studies on glycerin ethoxylates (glycereth-12 and glycereth-26). 2019. (Unpublished data submitted by the Personal Care Products Council on April 23, 2019).
30.
Anonymous. Summary- topical application ocular irritation screening assay using the EpiOcular human cell construct. 2019. (Unpublished data submitted by the Personal Care Products Council on June 11, 2019).
