This chapter will discuss the design issues of Biosafety Level 4 (BSL4) suit
laboratories. It will review the requirements of “Biosafety in Microbiological and
Biomedical Laboratories” (BMBL) (USDHHS, 1993), including revisions proposed for the 4th
edition, in greater detail and give the rationale behind some of the requirements of
laboratories at this level. The chapter will also detail issues related to layout and how
this impacts operation with a comparative review of contemporary facilities.
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