The increasing need to work with airborne infectious agents places greater reliance upon
the personnel and environmental protection that biocontainment facilities provide.
Ensuring that these facilities function properly depends on carefully reviewing
post-construction performance and establishing operating protocols that take advantage of
a facility's attributes while recognizing its individual limitations. Our review process
expands on the work done by others and provides a foundation for developing standard
certification procedures for biocontainment facilities.
References
1.
American Conference of Governmental
Industrial Hygienists (ACGIH). Industrial ventilation: A Manual of
Recommended Practice. 22nd edition, Cincinnati. ACGIH. 1995.
2.
American Society of Heating, Refrigeration
and Air-Conditioning Engineers (ASHRAE). Application Handbook. Chapter
7: Health Facilities. Atlanta. 1991. American Society of Heating, Refrigeration and
Air-Conditioning Engineers, Inc.
3.
BarbeitoM.S., AbrahamG., BestM., CairnsP., LangevinP., SterrittW.G., BarrD., MeulepasW., Sanchez-VizcaínoJ.M., SarazaM., RequenaE., ColladoM., ManiP., BreezeR., BrunnerH., MebusC.A., MorganR.L., RuskS., SiegfriedL.M. & ThompsonL.H.Recommended biocontainment features for research and diagnostic facilities
where animal pathogens are used. Rev. Sci. Tech. Off. Int.
Epiz. 1995. 14:873–887.
4.
Centers for Disease Control and Prevention
(CDC) and National Institute of Health (NIH). Biosafety in
Microbiological and Biomedical Laboratories. US Dept of Health
and Human Services, HHS Publication No. 93–8395, 3rd
edition, Washington. U.S.
Government Printing Office, 1993.
5.
Centers for Disease Control and
Prevention (CDC). Guidelines for preventing the transmission of
Mycobacterium tuberculosis in health-care facilities. MMWR, Vol. 43, RR-13, October 28, 1994.
6.
DiBerardinisL.J., BaumJ.S., FirstM.F., GatwoodG.T., GrodenE. & SethA.K.Guidelines for laboratory design: health and safety considerations. 2nd ed. New York, John
Wiley & Sons, 1993.
Health Canada, Laboratory Centre for Disease
Control (CLCDC). Laboratory Biosafety Guidelines. 2nd
edition. 1996. Ottawa. Minister of National Health and
Welfare.
9.
GersheyE.L., ReimanJ., WoodW. & PartyE.Evaluation of a room for TB patient isolation using theatrical
fog. Infection Control and Hospital Epidemiology, 1996, submitted for publication.
10.
LibermanD.F., editor. Biohazards management handbook. 2nd ed. New York, Marcel Dekker, 1995.
11.
National Sanitation Foundation
(NSF). Class II (laminar flow) biohazard
cabinetry. Standard, 49. 1992.
12.
PartyE., ReimanJ.S., VolinC.E., JoaoR.V. & GersheyE.L.Fume hood performance: monitoring instrumentation and
certification. Professional Safety. 1996. In press.
World Health Organization (WHO). Laboratory Biosafety Manual. Geneva. WHO. 1983.
15.
World Health Organization (WHO). Biosafety guidelines for personnel engaged in the production of vaccines and
biological products for medical use. WHO CDS/BVI/95.5. 1995.