This article represents a selective review of literature published in 2019. Initial results from PubMed searching for a combination of terms, including cardiac anesthesiology and anesthesiology outcomes, yielded more than 1400 publications. From there, we manually screened the results and identified 5 major themes for the year of 2019, including transcatheter techniques, delirium and anesthesiology, coagulation management following cardiopulmonary bypass, perfusion management with del Nido cardioplegia, and applied clinical research. The following research accomplishments have expanded what is possible and set ambitious goals for the future.
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2.
MackMJLeonMBThouraniVH, et al. Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med. 2019;380:1695-1705. doi:10.1056/NEJMoa1814052
3.
PopmaJJDeebGMYakubovSJ, et al. Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients. N Engl J Med. 2019;380:1706-1715. doi:10.1056/NEJMoa1816885
4.
PopmaJJAdamsDHReardonMJ, et al. Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery. J Am Coll Cardiol. 2014;63:1972-1981. doi:10.1016/j.jacc.2014.02.556
5.
AdamsDHPopmaJJReardonMJ, et al. Transcatheter aortic-valve replacement with a self-expanding prosthesis. N Engl J Med. 2014;370:1790-1798. doi:10.1056/NEJMc1408396
6.
ReardonMJVan MieghemNMPopmaJJ, et al. Surgical or transcatheter aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2017;376:1321-1331. doi:10.1056/NEJMoa1700456
7.
GleasonTGReardonMJPopmaJJ, et al. 5-Year outcomes of self-expanding transcatheter versus surgical aortic valve replacement in high-risk patients. J Am Coll Cardiol. 2018;72:2687-2696. doi:10.1016/j.jacc.2018.08.2146
8.
LeonMBSmithCRMackM, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363:1597-1607. doi:10.1056/NEJMoa1008232
9.
SmithCRLeonMBMackMJ, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364:2187-2198. doi:10.1056/NEJMoa1103510
10.
KapadiaSRLeonMBMakkarRR, et al. 5-Year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015;385:2485-2491. doi:10.1016/S0140-6736(15)60290-2
11.
MackMJLeonMBSmithCR, et al. 5-Year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015;385:2477-2484. doi:10.1016/S0140-6736(15)60308-7
12.
WebbJGDoshiDMackMJ, et al. A randomized evaluation of the SAPIEN XT transcatheter heart valve system in patients with aortic stenosis who are not candidates for surgery. JACC Cardiovasc Interv. 2015;8:1797-1806. doi:10.1016/j.jcin.2015.08.017
13.
ThouraniVHKodaliSMakkarRR, et al. Transcatheter aortic valve replacement versus surgical valve replacement in intermediate-risk patients: a propensity score analysis. Lancet Lond Engl. 2016;387:2218-2225. doi:10.1016/S0140-6736(16)30073-3
14.
LeonMBSmithCRMackMJ, et al. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2016;374:1609-1620. doi:10.1056/NEJMoa1514616
15.
NishimuraRAOttoCMBonowRO, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2017;70:252-289. doi:10.1016/j.jacc.2017.03.011
16.
BaumgartnerHFalkVBaxJJ, et al. 2017 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2017;38:2739-2791. doi:10.1093/eurheartj/ehx391
17.
NeuburgerPJSaricMHuangCWilliamsMR. A practical approach to managing transcatheter aortic valve replacement with sedation. Semin Cardiothorac Vasc Anesth. 2016;20:147-157. doi:10.1177/1089253215625111
18.
GuarracinoFBaldassarriR. The anesthetic management of transcatheter aortic valve implantation. Semin Cardiothorac Vasc Anesth. 2016;20:141-146. doi:10.1177/1089253215606220
19.
MarinoMLilieCJCulpWCJrSchepelSRTippettJC. The evolution of echocardiographic type and anesthetic technique for transcatheter aortic valve replacement at a high-volume transcatheter aortic valve replacement center. J Cardiothorac Vasc Anesth. 2019;33:29-35. doi:10.1053/j.jvca.2018.06.022
20.
AftabMClevelandJCJrReeceTB. Noteworthy literature published in 2016 for cardiac surgery. Semin Cardiothorac Vasc Anesth. 2017;21:30-35. doi:10.1177/1089253216688694
21.
SanetraKGerberWShresthaR, et al. The del Nido versus cold blood cardioplegia in aortic valve replacement: a randomized trial [published online June 28, 2019]. J Thorac Cardiovasc Surg. doi:10.1016/j.jtcvs.2019.05.083
22.
UcakHAUncuH. Comparison of del Nido and intermittent warm blood cardioplegia in coronary artery bypass grafting surgery. Ann Thorac Cardiovasc Surg. 2019;25:39-45. doi:10.5761/atcs.oa.18-00087
23.
JiangXLGuTYLiuLSongJZhouXYGuoZ. Safety of del Nido cardioplegia in coronary artery bypass grafting combined with heart valve replacement in adults [in Chinese]. Zhonghua Yi Xue Za Zhi. 2019;99:3770-3774. doi:10.3760/cma.j.issn.0376-2491.2019.48.003
24.
AdNHolmesSDMassimianoPSRongioneAJFornaresioLMFitzgeraldD. The use of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial. J Thorac Cardiovasc Surg. 2018;155:1011-1018. doi:10.1016/j.jtcvs.2017.09.146
25.
AnKRRahmanIATamDY, et al. A systematic review and meta-analysis of del Nido versus conventional cardioplegia in adult cardiac surgery. Innovations (Phila). 2019;14:385-393. doi:10.1177/1556984519863718
26.
OtaTYerebakanHNeelyRC, et al. Short-term outcomes in adult cardiac surgery in the use of del Nido cardioplegia solution. Perfusion. 2016;31:27-33. doi:10.1177/0267659115599453
27.
GörlingerKShore-LessersonLDirkmannDHankeAARahe-MeyerNTanakaKA. Management of hemorrhage in cardiothoracic surgery. J Cardiothorac Vasc Anesth. 2013;27(4, suppl):S20-S34. doi:10.1053/j.jvca.2013.05.014
28.
KarkoutiKCallumJCrowtherMA, et al. The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study. Anesth Analg. 2013;117:14-22. doi:10.1213/ANE.0b013e318292efa4
29.
WhiteNJWangYFuX, et al. Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury. Free Radic Biol Med. 2016;96:181-189. doi:10.1016/j.freeradbiomed.2016.04.023
30.
KaruITaalGZilmerKPruunsildCStarkopfJZilmerM. Inflammatory/oxidative stress during the first week after different types of cardiac surgery. Scand Cardiovasc J. 2010;44:119-124. doi:10.3109/14017430903490981
Fenger-EriksenCLindberg-LarsenMChristensenAQIngerslevJSørensenB. Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations. Br J Anaesth. 2008;101:769-773. doi:10.1093/bja/aen270
33.
BilecenSde GrootJAKalkmanCJ, et al. Effect of fibrinogen concentrate on intraoperative blood loss among patients with intraoperative bleeding during high-risk cardiac surgery: a randomized clinical trial. JAMA. 2017;317:738-747. doi:10.1001/jama.2016.21037
34.
CallumJFarkouhMEScalesDC, et al. Effect of fibrinogen concentrate vs cryoprecipitate on blood component transfusion after cardiac surgery: the FIBRES Randomized Clinical Trial. JAMA. 2019;322:1966-1976. doi:10.1001/jama.2019.17312
35.
MangusanRFHooperVDenslowSATravisL. Outcomes associated with postoperative delirium after cardiac surgery. Am J Crit Care. 2015;24:156-163. doi:10.4037/ajcc2015137
36.
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37.
BrownCHProbertJHealyR, et al. Cognitive decline after delirium in patients undergoing cardiac surgery. Anesthesiology. 2018;129:406-416. doi:10.1097/ALN.0000000000002253
38.
RudolphJLInouyeSKJonesRN, et al. Delirium: an independent predictor of functional decline after cardiac surgery. J Am Geriatr Soc. 2010;58:643-649. doi:10.1111/j.1532-5415.2010.02762.x
39.
GosseltANSlooterAJBoerePRZaalIJ. Risk factors for delirium after on-pump cardiac surgery: a systematic review. Crit Care. 2015;19:346. doi:10.1186/s13054-015-1060-0
40.
BurkhartCSDell-KusterSGamberiniM, et al. Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2010;24:555-559. doi:10.1053/j.jvca.2010.01.003
41.
BrownCH. Delirium in the cardiac surgical ICU. Curr Opin Anaesthesiol. 2014;27:117-122. doi:10.1097/ACO.0000000000000061
42.
LopezMGHughesCGDeMatteoA, et al. Intraoperative oxidative damage and delirium after cardiac surgery. Anesthesiology. 2020;132:551-561. doi:10.1097/ALN.0000000000003016
43.
SubramaniamBShankarPShaefiS, et al. Effect of intravenous acetaminophen vs placebo combined with propofol or dexmedetomidine on postoperative delirium among older patients following cardiac surgery: the DEXACET Randomized Clinical Trial. JAMA. 2019;321:686-696. doi:10.1001/jama.2019.0234
44.
PagelPSCrystalGJ. The discovery of myocardial preconditioning using volatile anesthetics: a history and contemporary clinical perspective. J Cardiothorac Vasc Anesth. 2018;32:1112-1134. doi:10.1053/j.jvca.2017.12.029
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46.
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