More than 3000 peer-reviewed publications on the topic of liver transplantation were published in 2016. The goal of this article is to provide a concise review of pertinent literature for anesthesiologists who participate in liver transplantation. The authors selected and presented 33 articles published in 2016 on the topics of MELD policy; cardiovascular, pulmonary, and renal issues; coagulation and transfusion; anesthetic agents; hemodynamic monitors; acute liver failure; and donor issues.
KimWRLakeJRSmithJM. Liver. Am J Transplant. 2016;16(suppl 2):69-98.
2.
ElwirSLakeJ.Current status of liver allocation in the United States. Gastroenterol Hepatol (N Y). 2016;12:166-170.
3.
MerionRMSchaubelDEDykstraDMFreemanRBPortFKWolfeRA.The survival benefit of liver transplantation. Am J Transplant. 2005;5:307-313.
4.
NekrasovVMatsuokaLRaufM. National outcomes of liver transplantation for MELD ≥ 40: the impact of Share 35 [published online April 11, 2016]. Am J Transplant. doi:10.1111/ajt.13823.
5.
BigginsSWKimWRTerraultNA. Evidence-based incorporation of serum sodium concentration into MELD. Gastroenterology. 2006;130:1652-1660.
6.
BigginsSWRodriguezHJBacchettiPBassNMRobertsJPTerraultNA.Serum sodium predicts mortality in patients listed for liver transplantation. Hepatology. 2005;41:32-39.
7.
RufAEKremersWKChavezLLDescalziVIPodestaLGVillamilFG.Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone. Liver Transpl. 2005;11:336-343.
8.
KimWRBigginsSWKremersWK. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med. 2008;359:1018-1026.
9.
VanWagnerLBSerperMKangR. Factors associated with major adverse cardiovascular events after liver transplantation among a national sample. Am J Transplant. 2016;16:2684-2694.
10.
KongYGKangJWKimYK. Preoperative coronary calcium score is predictive of early postoperative cardiovascular complications in liver transplant recipients. Br J Anaesth. 2015;114:437-443.
11.
BushyheadDKirkpatrickJNGoldbergD.Pretransplant echocardiographic parameters as markers of posttransplant outcomes in liver transplant recipients. Liver Transpl. 2016;22:316-323.
12.
ShillcuttSKRingenbergKJChaconMM. Liver transplantation: intraoperative transesophageal echocardiography findings and relationship to major postoperative adverse cardiac events. J Cardiothorac Vasc Anesth. 2016;30:107-114.
13.
BottoFAlonso-CoelloPChanMT. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014;120:564-578.
14.
HuangSApinyachonWAgopianVG. Myocardial injury in patients with hemodynamic derangements during and/or after liver transplantation. Clin Transplant. 2016;30:1552-1557. doi:10.1111/ctr.12855.
15.
ZardiEMZardiDMChinDSonninoCDobrinaAAbbateA.Cirrhotic cardiomyopathy in the pre- and post-liver transplantation phase. J Cardiol. 2016;67:125-130.
16.
SonnyAIbrahimASchusterAJaberWACywinskiJB.Impact and persistence of cirrhotic cardiomyopathy after liver transplantation. Clin Transplant. 2016;30:986-993.
17.
KrowkaMJFallonMBKawutSM. International Liver Transplant Society Practice Guidelines: diagnosis and management of hepatopulmonary syndrome and portopulmonary hypertension. Transplantation. 2016;100:1440-1452.
ARDS Definition Task Force; RanieriVMRubenfeldGDThompsonBT. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307:2526-2533.
20.
KiaLCutticaMJYangA. The utility of pulmonary function testing in predicting outcomes following liver transplantation. Liver Transpl. 2016;22:805-811.
21.
O’LearyJGLevitskyJWongFNadimMKCharltonMKimWR.Protecting the kidney in liver transplant candidates: practice-based recommendations from the American Society of Transplantation Liver and Intestine Community of Practice. Am J Transplant. 2016;16:2516-2531.
22.
LevitskyJO’LearyJGAsraniS. Protecting the kidney in liver transplant recipients: practice-based recommendations from the American Society of Transplantation Liver and Intestine Community of Practice. Am J Transplant. 2016;16:2532-2544.
23.
AtkinsDEcclesMFlottorpS. Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches. The GRADE Working Group. BMC Health Serv Res. 2004;4:38.
24.
GuyattGHOxmanADVistGE. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924-926.
25.
LaskeyHLSchomakerNHungKW. Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: the impact of warm ischemia time. Liver Transpl. 2016;22:1085-1091.
26.
YooSLeeHJLeeHRyuHG.Association between perioperative hyperglycemia or glucose variability and postoperative acute kidney injury after liver transplantation: a retrospective observational study. Anesth Analg. 2017;124:35-41.
27.
WeinbergLBroadJPillaiP. Sodium bicarbonate infusion in patients undergoing orthotopic liver transplantation: a single center randomized controlled pilot trial. Clin Transplant. 2016;30:556-565.
28.
HartmannMSzalaiCSanerFH.Hemostasis in liver transplantation: pathophysiology, monitoring, and treatment. World J Gastroenterol. 2016;22:1541-150.
29.
AbuelkasemELuSTanakaKPlaninsicRSakaiT.Comparison between thrombelastography and thromboelastometry in hyperfibrinolysis detection during adult liver transplantation. Br J Anaesth. 2016;116:507-512.
30.
AbuelkasemEMazzeffiMALuSYPlaninsicRMSakaiTTanakaKA.Ex vivo evaluation of 4 different viscoelastic assays for detecting moderate to severe coagulopathy during liver transplantation. Liver Transpl. 2016;22:468-475.
31.
Zahr EldeenFRollGRDerosasC. Preoperative thromboelastography as a sensitive tool predicting those at risk of developing early hepatic artery thrombosis after adult liver transplantation. Transplantation. 2016;100:2382-2390.
32.
SabateAGutierrezRBeltranJ. Impact of preemptive fibrinogen concentrate on transfusion requirements in liver transplantation: a multicenter, randomized, double-blind, placebo-controlled trial. Am J Transplant. 2016;16:2421-2429.
33.
Nicolau-RaducuRKuTCGanierDR. Epsilon-aminocaproic acid has no association with thromboembolic complications, renal failure, or mortality after liver transplantation. J Cardiothorac Vasc Anesth. 2016;30:917-923.
34.
HanSKimGKoJS. Safety of the use of blood salvage and autotransfusion during liver transplantation for hepatocellular carcinoma. Ann Surg. 2016;264:339-343.
35.
MonkTGWeldonBCGarvanCW. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008;108:18-30.
36.
AcetoPPerilliVLaiCCiocchettiPVitaleFSollazziL.Postoperative cognitive dysfunction after liver transplantation. Gen Hosp Psychiatry. 2015;37:109-115.
37.
MorandiABrummelNEElyEW.Sedation, delirium and mechanical ventilation: the “ABCDE” approach. Curr Opin Crit Care. 2011;17:43-49.
38.
XuGLiLLSunZTZhangWHanXP.Effects of dexmedetomidine on postoperative cognitive dysfunction and serum levels of b-amyloid and neuronal microtubule-associated protein in orthotopic liver transplantation patients. Ann Transplant. 2016;21:508-515.
39.
FayedNASayedEISalehSMEhsanNAElfertAY.Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation. Clin Transplant. 2016;30:470-482.
40.
AggarwalSKangYFreemanJA. Postreperfusion syndrome: cardiovascular collapse following hepatic reperfusion during liver transplantation. Transplant Proc. 1987;19(4suppl 3):54-55.
41.
Paugam-BurtzCKavafyanJMerckxP. Postreperfusion syndrome during liver transplantation for cirrhosis: outcome and predictors. Liver Transpl. 2009;15:522-529.
42.
AggarwalSKangYFreemanJA. Postreperfusion syndrome: hypotension after reperfusion of the transplanted liver. J Crit Care. 1993;8:154-160.
43.
LeeJYooYJLeeJMParkYJRyuHG.Sevoflurane versus desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation: a randomized controlled trial. Transplantation. 2016;100:600-606.
44.
KoJSGwakMSChoiSJ. The effects of desflurane and propofol-remifentanil on postoperative hepatic and renal functions after right hepatectomy in liver donors. Liver Transpl. 2008;14:1150-1158.
45.
Beck-SchimmerBBreitensteinSUrechS. A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg. 2008;248:909-918.
46.
KoJSGwakMSChoiSJ. The effects of desflurane and sevoflurane on hepatic and renal functions after right hepatectomy in living donors. Liver Transpl. 2010;23:736-744.
47.
Beck-SchimmerBBonviniJMSchaddeE. Conditioning with sevoflurane in liver transplantation: results of a multicenter randomized controlled trial. Transplantation. 2015;99:1606-1612.
48.
LeeMWeinbergLPearceB. Agreement in hemodynamic monitoring during orthotopic liver transplantation: a comparison of FloTrac/Vigileo at two monitoring sites with pulmonary artery catheter thermodilution [published online February 16, 2016]. J Clin Monit Comput. doi:10.1007/s10877-016-9840-x.
49.
MaloneyPRMalloryGWAtkinsonJLWijdicksEFRabinsteinAAVan GompelJJ.Intracranial pressure monitoring in acute liver failure: institutional case series. Neurocrit Care. 2016;25:86-93.
50.
JalanROlde DaminkSWDeutzNEHayesPCLeeA.Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology. 2004;127:1338-1346.
51.
BernalWMurphyNBrownS. A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure. J Hepatol. 2016;65:273-279.
52.
MillerCMDurandFHeimbachJK. The International Liver Transplant Society guideline on living liver donation. Transplantation. 2016;100:1238-1243.
53.
MillerCSmithMLFujikiM. Preparing for the inevitable: the death of a living liver donor. Liver Transpl. 2013;19:656-660.
54.
RösslerFSapisochinGSongG. Defining benchmarks for major liver surgery: a multicenter analysis of 5202 living liver donors. Ann Surg. 2016;264:492-500.
55.
MandellMSSmithARDewMA. Early postoperative pain and its predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study. Transplantation. 2016;100:2362-2371.
56.
Adult to Adult Living Donor Liver Transplantation Cohort Study. https://www.nih-a2all.org/. Accessed November 29, 2016.
57.
GordonDBPolomanoRCPellinoTA. Psychometrics of the revised American Pain Society Patient Outcome Questionnaire (APS-POQ) for quality improvement of acute and cancer pain management. J Pain. 2010;11:1172-1186.
58.
ChouRGordonDBde Leon-CasasolaOA. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17:131-157.
59.
de VeraMELopez-SolisRDvorchikI. Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant. 2009;9:773-781.
60.
LeeKWSimpkinsCEMontgomeryRALockeJESegevDLMaleyWR.Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation. 2006;82:1683-1688.
61.
SealJBBohorquezHReichmanT. Thrombolytic protocol minimizes ischemic-type biliary complications in liver transplantation from donation after circulatory death donors. Liver Transpl. 2015;21:321-328.
62.
FirlDJHashimotoKO’RourkeC. Role of donor hemodynamic trajectory in determining graft survival in liver transplantation from donation after circulatory death donors. Liver Transpl. 2016;22:1469-1481.
63.
JochmansIAkhtarMZNasrallaD. Past, present, and future of dynamic kidney and liver preservation and resuscitation. Am J Transplant. 2016;16:2545-2555.
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