Lung Protective Ventilation Strategies

Abstract

While traditional ventilation approaches are appropriate for the patient without significant lung disease and only requiring short-term mechanical ventilatory support, the strategy should be altered for the patient with severe lung disease. Research on the mechanisms of ventilator-induced lung injury has led to the development of mechanical ventilation strategies that imrove patient outcomes. The trend toward using lower tidal volmes, limited airway pressures, and PEEP have produced imroved outcome results. Predictive indices of outcome using laboratory values, biologic markers, and mediators of lung inury are being evaluated for early identification of patients at risk for lung injury. Nonconventional ventilatory approaches, such as noninvasive positive pressure ventilation and high freuency ventilation, as well as adjunctive therapies (inhaled niric oxide and extracorporeal circulation) are being explored as alternatives in ARDS and ALI. While more clinical studies outine outcomes in specific subgroups of patients, the ventilatoy strategy should continually be revised at the bedside.