Pharmacotherapy in Infantile Autism

Alfredsson, G. , Harnryd, C. , & Wiesel, F.A. (1985). Effects of sulpiride and chlorpromazine on autistic and positive psychotic symptoms in schizophrenic patients in relationship to drug concentrations. Psychopharmacology, 85, 8–13.

Aman, M.G. (1982). Stimulant drug effects in developmental disorders and hyper-activity: Toward a resolution of disparate findings.Journal of Autism and Developmental Disorder., 124, 385–399.

Aman, M.G. , & Singh, N. (1986). Aberrant behavior checklist. New York: Slosson Educational Publications.

American Psychiatric Association. (1987).Diagnostic and statistical manual of mental disorder. (3rd ed., rev.). Washington, DC: Author.

Anderson, L.T. , Campbell, M. , Adams, P. , Small, A.M. , Perry, R. , & Shell, J. (1989). The effects of haloperidol on discriminative learning and behavioral symptoms in autistic children.Journal of Autism and Developmental Disorder., 19(2), 227–239.

Anderson, L.T. , Campbell, M. , Grega, D.M. , Perry, R. , Small, A.M. , & Green, W.H. (1984). Haloperidol in infantile autism: Effects on learning and behavioral symptoms. American Journal of Psychiatry, 14(10), 1195–1202.

August, G.J. , Raz, N. , & Baird, T.D. (1987). Fenfluramine response in high and low functioning autistic children. Journal of the American Academy of Child and Adolescent Psychiatry, 2(3), 342–346.

Barrett, R.P. , Feinstein, C. , & Hole, W.T. (1989). Effects of naloxone and naltrexone on self-injury: A double-blind, placebo-controlled analysis. American Journal of Mental Retardation, 19(6), 644–651.

Barthelemy, C. , Bruneau, N. , Jouve, J. , Martineau, J. , Muh, J.P. , & Lelord, G. (1989). Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior. Journal of Autism and Developmental Disorders, 1(2), 241–254.

Birmaher, B. , Quintana, H. , & Greenhffl, L.L. (1988). Methylphenidate treatment of hyperactive autistic children. Journal of the American Academy of Child and Adolescent Psychiatry, 27(2), 248–251.

Campbell, M. (1988). Annotation-Fenfluramine treatment of autism. Journal of Child Psychology and Psychiatry, 29(1), 1–10.

Campbell, M. , Adams, P. , Small, A.M. , Curren, E.L. , Overall, J.E. , Anderson, L.T. , Lynch, N. , & Perry, R. (1988). Efficacy and safety of fenfluramine in autistic children.Journal of the American Academy of Child and Adolescent Psychiatr., 27 (4), 434–439.

Campbell, M. , Adams, P. , Small, A.M. , Tesch, L.M. , & Curren, E.L. (1988). Naltrexone in infantile autism. Psychopharmacology Bulletin, 24(1), 135–139.

Campbell, M. , Anderson, L.T. , Deutsch, S.L , & Green, W.H. (1984). Psychopharma cological treatment of children with the syndrome of autism.Pediatric Annal., 13 (4), 309–316.

Campbell, M. , Anderson, L.T. , Meier, M. , Cohen, L.L. , Small, A.M. , Samit, C. , & Sachar, E.J. (1978). A comparison of haloperidol and behavior therapy and their interaction in autistic children. Journal of the American Academy of Child and Adolescent Psychiatry, 17(4), 640–655.

Campbell, M , Cohen, L.L. , & Anderson, L.T. (1981). Pharmacotherapy for autistic children: A summary of research. Canadian Journal of Psychiatry, 26(4), 265–273.

Campbell, M. , Deutsch, S.L. Perry, R. , Wolsky, B.B. , & Palij, M. (1986). Short-term efficacy and safety of fenfluramine in hospitalized preschool-age autistic children: An open study. Psychopharmacology Bulletin, 22(1), 141–147.

Campbell, M. , Fish, B. , Shapiro, T. , & Floyd, A. (1971). Imipramine in preschool autistic and schizophrenic children. Journal of Autism and Childhood Schizophrenia, 1(3), 267–282.

Campbell, M. , Grega, D.M. , Green, W.H. , & Bennett, W.G. (1983). Neuroleptic induced dyskinesias in children. Clinical Neuropharmacology, 6(3), 207–222.

Campbell, M. , Perry, R. , Bennett, W.G. , Small, A.M. , Green, W.H. , Grega, D. , Schwartz, V. , & Anderson, L. (1983). Long-term therapeutic efficacy and drug-related abnormal movements: A prospective study of haloperidol in autistic children. Psychopharmacology Bulletin, 19(1), 80–83.

Campbell, M. , Small, A.M. , Collins, P.J. , Friedman, E. , David, R. , & Genieser, N. (1976). Levodopa and levoamphetamine: A crossover study in young schizophrenic children. Current Therapeutic Research, 19(1), 70–86.

Coggins, T.E. , Morisset, C. , Krasney, L. , Frederickson, R. , Holm, V.A. & Raisys, V. (1988). Brief report: Does fenfluramine treatment enhance the cognitive and communicative functioning of autistic children?.Journal of Autism and Developmental Disorder., 18(3), 425–433.

DeLong, G.R. , & Aldershof, A.L. (1987). Long-term experience with lithium treatment in childhood: Correlation with clinical diagnosis. Journal of the American Academy of Child and Adolescent Psychiatry, 26(3), 389–394.

Deutsch, S.L. (1986). Rationale for the administration of opiate antagonists in treating infantile autism. American Journal of Mental Deficiency, 90(6), 631–635.

DuVerglas, G. , Banks, S.R. , & Guyer, K.E. (1988). Clinical effects of fenfluramine on children with autism: A review of the research. Journal of Autism and Developmental Disorders, 18(2), 297–307.

Fish, B. (1960). Therapy in child psychiatry: Pharmacological aspects.Comprehensive Psychiatr., 1, 212—227.

Fish, B. (1971). The one child, one drug myth of stimulants in hyperkinesis. Archives of General Psychiatry, 25, 193–203.

Geller, B. , Guttmacher, L.B. , & Bleeg, M. (1981). Coexistence of childhood onset pervasive developmental disorder and attention deficit disorder with hyperactivity. American Journal of Psychiatry, 138(3), 388–389.

Geller, E. , Ritvo, E.R. , Freeman, B.J. , & Yuwiler, A. (1982). Preliminary observations on the effect of fenfluramine on blood serotonin and symptoms in three autistic boys. New England Journal of Medicine, 307(3), 165–169.

Gillberg, C. , Svennerholm, L. , & Hamilton-HeUberg, C. (1983). Childhood psychoses and monoamine metabolites in spinal fluid. Journal of Autism and Developmental Disorders, 13(4), 383–396.

Gillberg, C. , Terenius, L. , & Lonnerholm, G. (1985). Endorphin activity in childhood psychosis. Archives of General Psychiatry, 42, 780–783.

Gillberg, C. , Wahlstrom, J. , Johansson, R. , Tornblom, M. , & Albertsson-Wikland, K. (1986). Folic acid as an adjunct in the treatment of children with the autism fragile-x syndrome (AFRAX). Developmental Medicine and Child Neurology, 28, 624–627.

Goodman, L.S. , Gilman, A.G. , Rall, T.W. , & Murad, F. (Eds.). (1985).Goodman and Gilman's-The pharmacological basis of therapeutic. ( 7th ed. ). New York: Macmillan.

Groden, G. , Groden, J. , Dondey, M. , Zane, T. , Pueschel, S.M. , & Veliceur, W. (1987). Effects of fenfluramine on the behavior of autistic individuals. Research in Developmental Disabilities, 8, 203–211.

Gualtieri, C.T. (1977). Imipramins and children: A review and some speculations about the mechanism of drug action. Disease of Nervous System, 38, 368–374.

Hanky, H.G. , Stahl, S.M. , & Freeman, D.X. (1977). Hyperserotonemmia and amine metabolites in autistic and retarded children. Archives of General Psychiatry, 34, 521–531.

Harnryd, C. , Bjerkenstedt, L. , Bjork, K. , Gullberg, B. , Oxenstierna, G. , Sedvall, G. , Wiesel, F.A. , Wik, G. , & Aberg-Wistedt, A. (1984). Clinical evaluation of sulpiride in schizophrenic patients-A double-blind comparison with chlorpromazine.Acta Psychiatrica Scandinavic., 69 (Suppl. 311), 7–29.

Herman, B.H. , Hammock, M.K. , Arthur-Smith, A. , Kuehl, K. , & Appelgate, K. (1989). Effects of acute administration of naltrexone on cardiovascular function, body temperature, body weight, and serum concentrations of liver enzymes in autistic children. Developmental Pharmacology and Therapeutics, 12, 118–127.

Holm, V.A. , & Varley, C.K. (1989). Pharmacological treatment of autistic children. In G. Dawson (EA.),.Autism–Nature, diagnosis and treatmen. (pp. 386–404). New York: Guilford Press.

Jenkins, S.C. , & Maruta, T. (1987). Therapeutic use of propranolol for intermittent explosive disorder. Mayo Clinic Proceeding, 62, 204–214.

Kerbeshian, J. , Burd, L. , & Fisher, W. (1987). Lithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatology. Journal of Clinical Psychopharmacology, 7, 401–405.

Komoto, J. , Usui, S. , & Hirata, J. (1984). Infantile autism and affective disorder.Journal of Autism and Developmental Disorder., 14 (1), 81–84.

Leboyer, M. , Bouvard, M.P. , & Dugas, M. (1988). Effects of naltrexone on infantile autism.Lance., 1(8587), 715.

Lipinski, J.F. , Keck, P.E. , & McElroy, S.L. (1988). B-adrenergic antagonists in psychosis: Is improvement due to treatment of neuroleptic-induced akathesia?.Journal of Clinical Psychopharmacolog., 8(6), 409–416.

Martineau, J. , Barthelemy, C. , Cheliakine, C. , & Lelord, G. (1988). Brief report: An open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment. Journal of Autism and Developmental Disorders, 18(3), 435–447.

Martineau, J. , Barthelemy, C. , Garreau, B. , & Lelord, G. (1985). Vitamin B6, magnesium, and combined B6-Mg: Therapeutic effects in childhood autism. Biological Psychiatry, 20, 476–478.

Matson, J.L. , Barrett, R.P. , & Helsel, W.J. (1988). Depression in mentally retarded children. Research in Developmental Disabilities, 9, 39–46.

McDaniel, K.D. (1986). Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2). Clinical Pediatrics, 2(3), 143–146.

Meiselas, K.D. , Spencer, E.K. , Oberfield, R. , Peselow, E.D. , Angrist, B. , & Campbell, M. (1989). Differentiation of stereotypics from neuroleptic-related dyskinesias in autistic children. Journal of Clinical Psychopharmacology, 9(3), 207–209.

Minshew, N.J. , & Payton, J.B. (1988a). New perspectives in autism, part 1: The clinical spectrum of autism. Current Problems in Pediatrics, 987, 567–610.

Minshew, N.J. , & Payton, J.B. (1988b). New perspectives in autism, part 2: The differential diagnosis and neurobiology of autism. Current Problems in Pediatrics, 988, 615–694.

Panksepp, J. , & Sahley, T.L. (1987). Possible brain opioid involvement in disrupted social intent and language development in autism. In E. Schopler & G.B. Meslbov (Eds.),.Neurobiological issues in autis. (pp. 357–372). New York: Plenum Press.

Perry, R. , Campbell, M. , Adams, P. , Lynch, N. , Spencer, E.K. , Curren, E.L. , & Over all, J.E. (1989). Long-term efficacy of haloperidol in autistic children: Continuous versus discontinuous drug administration.Journal of the American Academy of Child and Adolescent Psychiatr., 28 (1), 87–92.

Ratey, J.J. , Bemporad, J. , Sorgi, P. , Bick, P. , Polakoff, S. , ODriscoll, G. , & Mikkelsen, E. (1987). Brief report: Open trial effects of beta-blockers on speech and social behaviors in 8 autistic adults.Journal of Autism and Developmental Disorder., 17 (3), 439–446.

Ratey, J.J. , Mikkelsen, E. , Sorgi, P. , Zuckerman, H.S. , Polakoff, S. , Bemporal, J. , Bick, P. , & Kadish, W. (1987). Autism: The treatment of aggressive behaviors. Journal of Clinical Psychopharmacology, 7(1), 35–41.

Realmuto, G.M. , August, G.J. , & Garfinkel, B.D. (1989). Clinical effect of buspirone in autistic children. Journal of Clinical Psychopharmacology, 9(2), 122–125.

Reiss, A.L. , Egel, A.L. , Feinstein, C. , Goldsmith, B. , & Borengasser-Caruso, M.A. (1988). Effects of fenfluramine on social behavior in autistic children. Journal of Autism and Developmental Disorders, 18(4), 617–625.

Rimland, B. (1973). High dosage levels of certain vitamins in the treatment of children with severe mental disorders. In D. Hawkins & L. Pauling (Eds.),.Orthomolecular psychiatr. (pp. 513–539). San Francisco: W.H. Freeman.

Rimland, B. (1988). Controversies in the treatment of autistic children: Vitamin and drug therapy.Journal of Child Neurolog., 3, Suppl. S68–S72.

Ritvo, E.R. , & Freeman, B.J. (1984). A medical model of autism: Etiology, pathology, and treatment. Pediatric Annals, 13(4), 298–305.

Ritvo, E.R. , Freeman, B.J. , Yuwiler, A. , Geller, E. , Schroth, P. , Yokota, A. , Mason-Brothers, A. , August, G.J. , Ktykylo, W. , Leventhal, B. , Lewis, K. , Piggott, L. , Real muto, G. , Stubbs, E.G. , & Umansky, R. (1986). Fenfluramine therapy for autism: Promise and precaution. Psychopharmacology Bulletin, 22(1), 133–140.

Ritvo, E.R. , Freeman, B.J. , Yuwiler, A. , Geller, E. , Yokata, A. , Schroth, P. , & Novak, P. (1984). Study of fenfluramine in outpatients with the syndrome of autism. Journal of Pediatrics, 105, 823–828.

Ritvo, E.R. , Yuwiler, A. , Geller, E. , Ornitz, E.M. , Saeger, K. , & Plotkin, S. (1970). Increased blood serotonin and platelets in early infantile autism. Archives of General Psychiatry, 23, 566–572.

Robbins, T. W. , & Sahakian, B.J. (1979). “Paradoxical” effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioral pharmacology. Neuropharmacology, 18, 931–950.

Rutter, M. , & Schopler, E. (1987). Autism and pervasive developmental disorders. Journal of Autism and Developmental Disorders, 17(2), 159–186.

Sahley, T.L. , & Panksepp, J. (1987). Brain opioids and autism: An updated analysis of possible linkages. Journal of Autism and Developmental Disorders, 17(2), 201–216.

Schaumburg, H. , Kaplan, J. , Windebank, A. , Vick, N. , Rasmus, S. , Pleasure, D. , & Brown, M. (1983). Sensory neuropathy from pyridoxine abuse: A new megavitamin syndrome. New England Journal of Medicine, 309, 445–448.

Schopler, E. (1982). Evaluation of treatment for autistic children and their parents. Journal of the American Academy of Child Psychiatry, 21, 262–267.

Steingard, R. , & Biederman, J. (1987). Lithium responsive maniclike symptoms in two individuals with autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry, 26(6), 632–635.

Strayhorn, J.M. , Rapp, N. , Donina, W. , & Strain, P.S. (1988). Randomized trial of methylphenidate for an autistic child. Journal of the American Academy of Child and Adolescent Psychiatry, 27(2), 244–247.

Szymanski, L. , Kedesdy, J. , Sulkes, S. , Cutler, A. , & Stevens-Orr, P. (1987). Naltrex-one in treatment of self-injurious behavior: A clinical study. Research in Developmental Disabilities, 8, 179–190.

Tonge, B.J. (1989). Autism. Australian Family Physician, 18(3), 247–249.

Weizman, R. , Weizman, A. , Tyano, S. , Szekety, G. , Weissman, B.A. , & Same, Y. (1984). Humoral-endorphin blood levels in autistic, schizophrenic and healthy subjects. Psychopharmacology, 82, 368–370.

Wiener, J.M. (1984). Psychopharmacology in childhood disorders. Psychiatric Clinics of North America, 7(4), 831–843.

Williams, D.T. , Mehl, R. , Yudofsky, S. , Adams, D. , & Roseman, B. (1982). The effect of propranolol on uncontrolled rage outbursts in children and adolescents with organic brain dysfunction. Journal of the American Academy of Child Psychiatry, 21(2), 129–135.

Young, J.G. , Kavanagh, M.E. , Anderson, G.M. , Shaywitz, B.A. , & Cohen, D.J. (1982). Clinical neurochemistry of autism and associated disorders.Journal of Autism and Developmental Disorder., 12 (2), 147–165.

Yuwiler, A. , & Freedman, D.X. (1987). Neurotransmitter research in autism. In E. Schopler & G.B. Mesilov (Eds.),.Neurobiological issues in autis. (pp. 263–284). New York: Plenum Press.