Limited caregiver-mediated naturalistic developmental behavioral interventions’ (NDBIs) research exists with the Latine community. To understand the effectiveness of caregiver-mediated NDBI, we must investigate feasibility and effectiveness with marginalized populations to assure family-centered and culturally sensitive care. This study examined the effects of a caregiver-mediated NDBI with three caregiver–child dyads using single-case design (SCD) research informed by a brief priori cultural adaptation. Caregivers demonstrated improved implementation fidelity of NDBI strategies with empowerment-based coaching. We discuss Latine caregiving practices and make recommendations for culturally congruent NDBI caregiver coaching.
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