Centers for Disease Control and Prevention. Sexually Transmitted Infections Surveillance, 2024. Atlanta, GA. U.S. Department of Health and Human Services. 2025. Available from: https://www.cdc.gov/std/statistics/2024/default.htm [January 2026].
2.
ChanPA, Le BrazidecDL, BecasenJS, et al.Safety of longer-term doxycycline use: A systematic review and meta-analysis with implications for bacterial STI chemoprophylaxis. Sex Transm Dis, 2023; 50(11):701–712; doi: 10.1097/OLQ.0000000000001865
3.
MolinaJ-M, CharreauI, ChidiacC, et al.; ANRS IPERGAY Study Group. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: An open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis, 2018; 18(3):308–317; doi: 10.1016/S1473-3099(17)30725-9
4.
LuetkemeyerAF, DonnellD, DombrowskiJC, et al.; DoxyPEP Study Team. Postexposure doxycycline to prevent bacterial sexually transmitted infections. N Engl J Med, 2023; 388(14):1296–1306; doi: 10.1056/NEJMoa2211934
5.
BachmannLH, BarbeeLA, ChanPA, et al.CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention, United States, 2024. MMWR Recomm Rep, 2024; 73(2):1–8; doi: 10.15585/mmwr.rr7302a1
6.
ChanPA, MalyutaY, ParentH, et al.Early adopters of doxycycline as post-exposure prophylaxis to prevent bacterial sexually transmitted infections in a real-world clinical setting. Sex Transm Infect, 2024; 100(6):339–342; doi: 10.1136/sextrans-2024-056152
7.
YonkoEA, BielloKB, Cormack OrellanaC, et al.DoxyPEP implementation preferences for bacterial STD prevention among gay, bisexual, and other men who have sex with men living with and without HIV in Los Angeles: A mixed-methods approach. AIDS Patient Care STDS, 2025; 39(3):84–93; doi: 10.1089/apc.2024.0252
8.
HaalandRE, FountainJ, EdwardsTE, et al.Pharmacokinetics of single-dose doxycycline in the rectum, vagina, and urethra: Implications for prevention of bacterial sexually transmitted infections. EBioMedicine, 2024; 101:105037; doi: 10.1016/j.ebiom.2024.105037
9.
RubensteinE, MolinaJ-M. Doxycycline to prevent bacterial sexually transmitted infections: A promising intervention. AIDS, 2025; 39(12):1677–1687; doi: 10.1097/QAD.0000000000004233