A program has been written to transfer a set of discontinuous samples in 96-well storage plates to archival plates using an 80-well format. One thousand samples per day can be processed in this manner. The software can handle different sample volumes, random sample locations, and varying concentrations. This program was implemented on a Beckman (Fullerton, CA) Biomek(r) 2000 Laboratory Automation Workstation* using Beckman's BioScript software, BioWorks 1.4A, Tool Command language, and Microsoft (Redmond, WA) Visual Basic™. This system provides an effective means of selecting and transferring discrete samples.
References
1.
Bauer, B. (1996). Automation issues at the interface between combinatorial chemistry and high-throughput screening. In Molecular Diversity and Combinatorial Chemistry. I.M Chaiken and K.D. Janda (eds.), pp. 233-243. ACS, Washington, DC.
2.
Beggs, M. (1997). Use of a two-armed Zymark robot for high throughput screening. J. Biomol. Screen. 2:2.
3.
Reichman, M., Marples, E., and Lenz, S. (1996). Approaches to automation for high-throughput screening. Lab Rob. Autom.8:5.
4.
Brandt, D. (1997). Multiplexed nanoliter transfers for high throughput drug screening using the Biomek 2000 and the high density replicating tool. J. Biomol. Screen.2:2.
5.
Wondka, N. (1996). Advanced Programming of the Biomek 2000 Using BioScript and TCL. Beckman Technical Publication.
6.
Ousterhout, J. (1994). Tcl and the Tk Toolkit. Addison-Wesley, Reading, MA.
7.
Hamilton, S., Armstrong, J., Gerren, R., Janssen, A., Peterson, J., and Stanton, R. (1996). An overview of automated biotechnology screening. Lab. Rob. Autom.8:5.
8.
Hardin, J., Smietana, F. (1995). Automating combinatorial chemistry: A primer on benchtop on robotic systems. Molecular Diversity1:4.
