Abstract
TripleTOF 6600 System with SWATH Acquisition 2.0 and BioPharmaView Software
This high-resolution, accurate mass system, combined with the new SWATH Acquisition 2.0, is for proteomic data challenges for advanced biomarker discovery and systems biology. The solution enables the quantification of thousands of proteins across large sample sets with data completeness and quantitative accuracy and precision.
AB SCIEX SWATH Acquisition incorporates a data-independent acquisition strategy and can fragment every detectable peptide in the sample to acquire quantitative MS/MS data. According to AB SCIEX, this approach has been shown to increase the capacity of targeted proteomics experiments by more than 30-fold and reduce study time by as much as 90%. The increased dynamic range of the TripleTOF 6600 System allows deeper interrogation of complex samples, and variable window acquisition and the SWATH 2.0 processing software improve quantitative results.
According to AB SCIEX, its BioPharmaView Software automates core workflows with investigative capabilities and fast data acquisition for the characterization of biotherapeutics such as monoclonal antibodies and emerging protein classes at both the intact protein and peptide levels. The software can efficiently analyze and compare batches while monitoring critical quality attributes according to the Food and Drug Administration’s well-characterized biotherapeutic product model.
More: www.absciex.com
Artel
ArtelWare Software
This software application is for use with new and existing multichannel verification systems (MVS) and enables MVS users to track and manage the performance of their automated liquid handlers. ArtelWare aggregates the standardized measurements from the MVS for all of a user’s liquid handlers, providing detailed, actionable performance information and insight for the management of these critical laboratory tools.
Users can quickly visualize the tip-by-tip status of any device as well as view performance over time and across multiple labs. Action limits can either be preassigned or determined based on the data. ArtelWare also provides the tools to manage and optimize instrument maintenance by viewing historical information on individual device availability and reliability. ArtelWare reduces troubleshooting time and expense by visualizing trends in instrument performance and enabling users to react to those trends before failures occur. ArtelWare can reduce time spent on false hits.
More: www.artel-usa.com
Beckman Coulter Life Sciences
Kaluza for Gallios Flow Cytometry Analysis Software
This next-generation acquisition software for the Beckman Coulter Gallios Cytometer combines data acquisition tools with ease of use to increase efficiency and performance in cell characterization and analysis workflows. Novel functionalities include the ability to set up experimental protocols offline and a Gallios simulator, which facilitates instrument training without running live experiments. The new software combines with Kaluza Analysis, a cytometry data analysis program, and together the packages provide a total cytometry data management solution.
Kaluza for Gallios features a guided Windows-based drag-and-drop interface that is intuitive and facilitates easy creation of the right setup for accurate plot output. Visual management tools enable tracking of instrument function and experiment progress. Voltage and compensation can be quickly, accurately, and intuitively changed. The wizard function creates compensation matrices, and a radial menu means minimal click-through while creating gates and accessing editing tools. Unlimited “undo” aids new users. Kaluza for Gallios flow cytometry analysis software is provided on a Windows 7 (64-bit) operating system.
More: www.kaluzasoftware.com
BioTek Instruments
LHC SiLA Liquid-Handling Control Software
LHC SiLA is a liquid-handling control software that allows any BioTek LHC-controlled washer or dispenser to be integrated into a robotic system with SiLA compliance. Compatible instruments include EL406, 405 Touch, 405 LS, ELx405 Select Deep Well, MultiFlo, and MultiFlo FX. BioTek’s LHC SiLA driver was developed in accordance with the Consortium for Standardization in Lab Automation’s (SiLA’s) published set of universal methods for microplate washers and dispensers.
According to BioTek, benefits include flexibility in instrument component and automated system selection; fast, cost-effective, and seamless integration with automated systems; and conformity with SiLA standards.
More: www.biotek.com
Genedata
Genedata Screener 12
According to Genedata, the latest version of this single-platform screening solution provides new capabilities for data analysis of technologies such as surface plasmon resonance (SPR), thermal shift, combination and panel screens; broadens workflow support; and minimizes data analysis time. It features advanced image management functionality and a newly designed Analyzer module, which optimizes user efficiency and productivity—from loading data to generating final analysis results.
Now, Genedata Screener also completely automates processing, from data import to results, which is considered especially useful in multistep data analysis such as dose-response curve and compound combination experiments and in preprocessing for time-series and single-cell data. The new release also offers ease-of-use enhancements, time-saving features and enables the platform to be easily customized.
Highlights include an Integrated Screener Core, which is a single application for accelerating the complete workflow, enabling complete analysis parameterization, automated result calculation upon data import, and single-click navigation from dose-response curves to well data and back. Screener for SPR analyzes data from any biosensor instrument and standardizes and automates SPR raw data loading, preprocessing, analysis, result generation, and reporting. Screener for Combina-tion Screening computes synergy effects (using Loewe, Bliss) and offers enhanced display of combination results. There is flexible support for panel screens to measure multiple targets or cell lines in one experiment and streamlined image management for multi-instrument environments with fast secondary analysis.
More: www.genedata.com
Oxford Gene Technology (OGT)
CytoSure Interpret Software 4.5.3
Complimentary with all CytoSure array purchases, CytoSure Interpret Software is described by OGT as a powerful and easy-to-use package for the analysis of aCGH data and copy number variation (CNV) detection. Offering a combination of features, including Automatic Aberration Classification, the software allows the choice of standardized or customized user-defined data analysis.
This latest version further facilitates and standardizes the data analysis workflow to deliver rapid access to meaningful results. By using information available in online databases, such as DECIPHER and settings defined by the user, the Automatic Aberration Classi-fication enables users to configure the software to automatically perform an initial classification of any detected CNV, accelerating analysis and standardizing the interpretation process.
CytoSure Interpret Software allows simultaneous access to sample and experiment information across a network, providing the potential for labs at multiple sites to access a central database. In situations in which IT infrastructures do not permit this, the software now provides the additional functionality for exporting sample and experiment information into other databases, further facilitating sharing of case information and aberration calls. In addition to the free text phenotype field, users are also now able to use Standardized Phenotype (Human Phenotype Ontology [HPO]) terms to simplify and normalize the phenotype description process via a HPO Phenotype Selector window.
More: www.ogt.com/interpret
QIAGEN
BIOBASE and Ingenuity Knowledge Base
QIAGEN’s portfolio of bioinformatics solutions now includes BIOBASE biological databases, software, and services. With access to HGMD, QIAGEN expands itself as a literature source for research and diagnosis and the analysis and interpretation of next-generation sequencing data.
BIOBASE offers interpretation solutions organized in an easily searchable manner that enable users to identify connections between disparate pieces of information and apply that knowledge. In addition to the continued availability of BIOBASE products on a standalone basis, QIAGEN is integrating first products into QIAGEN’s Ingenuity Knowledge Base and the QIAGEN bioinformatics solutions that draw upon it, including the HGMD Human Gene Mutation Database and PGMD PharmacoGenomic Mutation Database. HGMD integration also is available to users of QIAGEN’s Ingenuity Variant Analysis and will be included in Ingenuity Clinical, a new Web-based solution for clinical interpretation and reporting of insights from NGS-based tests.
GeneGlobe Genes & Pathways Web Portal
GeneGlobe is a Web-based solution that enables users to search and select from more than 31 million PCR assay kits and NGS assay panel products. It includes genome-wide assay solutions for 28 species with any gene or pathway of interest. The search, selection, and interpretation solutions create a user experience that precisely identifies assays and reagents that fit a user’s experimental design and adds a comprehensive set of interpretation solutions. GeneGlobe also supports scientists with additional resources such as Pathway Central, Data Analysis Center, Custom Assay Design Tools, and the Plate Designer.
This new version integrates biological knowledge through its Ingenuity Target Explorer bioinformatics application with GeneGlobe’s library of wet lab assay solutions. By linking biological interpretation and references with the relevant laboratory assays, GeneGlobe offers utility for experimental design, assay selection, and data analysis.
More: www.geneglobe.com
Ventana Medical Systems
Ventana Vector Software
This new platform for pathology training and collaboration provides tools to build interactive training, from course development to student evaluation, and can be used to quickly and easily share scanned images with colleagues around the globe. Ventana Vector software can help standardize training content by enabling students to view high-quality, consistent slide images and eliminating the frustration of having to share limited resources such as slide sets and multihead microscopes. It offers a fully customizable interface and the ability for users to view on mobile devices with both cloud and local hosting options, and it is fully compatible with iScan Coreo and Ventana iScan HT slide scanners.
More: www.ventana.com
About the JBS Product Focus Column
E-mail news releases for consideration to nhallock@slas.org. MSWord documents and 300+ dpi image files are preferred. Deadlines are at least two months prior to publication. JBS editors reserve the right to select the products they deem most appropriate for the section and may revise copy as necessary. Product descriptions are based on information provided by the manufacturer. Inclusion in this section in no way implies endorsement by the Journal of Biomolecular Screening or the Society for Laboratory Automation and Screening.