Effects of Chronotherapeutic Interventions in Adults With ADHD and Delayed Sleep Phase Syndrome (DSPS) on Regulation of Appetite and Glucose Metabolism

Abstract

Background: ADHD is highly comorbid with Delayed Sleep Phase Syndrome (DSPS). Both are associated with obesity and diabetes, which can be caused by long-term dysregulations of appetite and glucose metabolism. This study explores hormones involved in these processes and the effects of chronotherapeutic interventions in a small sample of adults with ADHD and DSPS. Methods: Exploratory, secondary analysis of data from the PhASE study, a three-armed randomized clinical trial, are presented, including 37 adults (18–53 years) with ADHD and DSPS receiving three weeks of 0.5 mg/day (1) placebo, (2) melatonin, or (3) melatonin plus 30 minutes of bright light therapy (BLT). Leptin (appetite-suppressing), ghrelin (appetite-stimulating), insulin, insulin-like growth factor-1 (IGF-1), and glucose were measured from blood collected at 08:00 hours. Salivary cortisol was collected during the first 30 minutes after awakening and self-reported appetite was assessed. Results: Baseline leptin and IGF-1 levels were higher than reference ranges, and ghrelin and cortisol levels were lower, while insulin and glucose were normal. Melatonin treatment decreased leptin and insulin. Other outcomes remained unchanged and melatonin + BLT had no effects. Conclusion: Due to the small sample size and exploratory nature of the study, results should be interpreted with caution. Overall, these results show no strong indications for dysregulation of appetite and glucose metabolism to suggest high risk of obesity and diabetes in this small sample of adults with ADHD and DSPS. However, baseline appetite was suppressed, likely because measurements took place in the early morning which could be considered the biological night for this study population. Melatonin treatment seemed to cause subtle changes in appetite-regulating hormones suggesting increased appetite. Chronotherapeutic treatment may affect appetite-regulating hormones by advancing the biological rhythm and/or altering eating behaviors, but this remains to be investigated in larger samples using detailed food diaries.

Keywords

ADHD delayed sleep biomarkers chronotherapy melatonin

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References

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.; DSM-5) (5th ed.). American Psychiatric Association.

Andrews

R. C.

Walker

B. R.

(1999). Glucocorticoids and insulin resistance: Old hormones, new targets. Clinical Science, 96(5), 513–523. https://doi.org/10.1042/cs0960513

Anothaisintawee

Reutrakul

Van Cauter

(2016). Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis. Sleep Medicine Reviews, 30, 11–24. https://doi.org/10.1016/j.smrv.2015.10.002

Bailey

S. L.

Heitkemper

M. M.

(1991). Morningness-eveningness and early-morning salivary cortisol levels. Biological Psychology, 32(2–3), 181–192. https://doi.org/10.1016/0301-0511(91)90009-6

Bailey

S. L.

Heitkemper

M. M.

(2001). Circadian rhythmicity of cortisol and body temperature: Morningness-eveningness effects. Chronobiology International, 18(2), 249–261. https://doi.org/10.1081/CBI-100103189

Baird

A. L.

Coogan

A. N.

Siddiqui

Donev

R. M.

Thome

(2012). Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Molecular Psychiatry, 17(10), 988–995. https://doi.org/10.1038/mp.2011.149

Benloucif

Burgess

H. J.

Klerman

E. B.

Lewy

A. J.

Middleton

Murphy

P. J.

Parry

B. L.

Revell

V. L.

(2008). Measuring melatonin in humans. Journal of Clinical Sleep Medicine, 4(1), 66–69. https://doi.org/10.5664/jcsm.27083

Bijlenga

Van der Heijden

K. B.

Breuk

Van Someren

E. J. W.

Lie

M. E. H.

Boonstra

A. M.

Swaab

H. J.

Kooij

J. J. S.

(2013). Associations between sleep characteristics, seasonal depressive symptoms, lifestyle, and ADHD symptoms in adults. Journal of Attention Disorders, 17(3), 261–275. https://doi.org/10.1177/1087054711428965

Bijlenga

Van Someren

E. J. W.

Gruber

Bron

T. I.

Kruithof

I. F.

Spanbroek

E. C. A.

Kooij

J. J. S.

(2013). Body temperature, activity and melatonin profiles in adults with attention-deficit/hyperactivity disorder and delayed sleep: A case-control study. Journal of Sleep Research, 22(6), 607–616. https://doi.org/10.1111/jsr.12075

10.

Bijlenga

Vollebregt

M. A.

Kooij

J. J. S.

Arns

(2019). The role of the circadian system in the etiology and pathophysiology of ADHD: Time to redefine ADHD? ADHD Attention Deficit and Hyperactivity Disorders, 11(1), 5–19. https://doi.org/10.1007/s12402-018-0271-z

11.

Bjorvatn

Pallesen

(2009). A practical approach to circadian rhythm sleep disorders. Sleep Medicine Reviews, 13(1), 47–60. https://doi.org/10.1016/j.smrv.2008.04.009

12.

Bonvicini

Faraone

S. V.

Scassellati

(2016). Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Molecular Psychiatry, 21(7), 872–884. https://doi.org/10.1038/mp.2016.74

13.

Bouman

E. J.

Beulens

J. W. J.

Groeneveld

de Kruijk

R. S.

Schoonmade

L. J.

Remmelzwaal

Elders

P. J. M.

Rutters

(2023). The association between social jetlag and parameters of metabolic syndrome and type 2 diabetes: A systematic review and meta-analysis. Journal of Sleep Research, 32(3), e13770. https://doi.org/10.1111/jsr.13770

14.

Buxton

O. M.

Pavlova

Reid

E. W.

Wang

Simonson

D. C.

Adler

G. K.

(2010). Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes, 59(9), 2126–2133. https://doi.org/10.2337/db09-0699

15.

Capers

P. L.

Fobian

A. D.

Kaiser

K. A.

Borah

Allison

D. B.

(2015). A systemic review and meta-analysis of randomized controlled trials of the impact of sleep duration on adiposity and components of energy balance. Obesity Reviews, 16(9), 771–782. https://doi.org/10.1111/obr.12296

16.

Chang

J. P. C.

K. P.

Mondelli

Pariante

C. M.

(2021). Cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD): Evidence from a systematic review with meta-analysis. Translational Psychiatry, 11(1), 430. https://doi.org/10.1038/s41398-021-01550-0

17.

Chen

H. J.

Lee

Y. J.

Yeh

G. C.

Lin

H. C.

(2013). Association of attention-deficit/hyperactivity disorder with diabetes: A population-based study. Pediatric Research, 73(4), 492–496. https://doi.org/10.1038/pr.2013.5

18.

Chen

M.-H.

Pan

T.-L.

Hsu

J.-W.

Huang

K.-L.

T.-P.

C.-T.

Lin

W. C.

Tsai

S. J.

Chang

W. H.

Chen

T. J.

Bai

Y.-M.

(2018). Risk of type 2 diabetes in adolescents and young adults with attention-deficit/hyperactivity disorder: A nationwide longitudinal study. The Journal of Clinical Psychiatry, 79(3), 17m11607. https://www.psychiatrist.com/jcp/mental/child/adhd-and-type-diabetes-mellitus/

19.

Chen

Hartman

C. A.

Haavik

Harro

Klungsøyr

Hegvik

T. A.

Wanders

Ottosen

Dalsgaard

Faraone

S. V.

Larsson

(2018). Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: A population-based cross-sectional study. PLoS One, 13(9), e0204516. https://doi.org/10.1371/journal.pone.0204516

20.

Clemmons

D. R.

(2004). Role of insulin-like growth factor I in maintaining normal glucose homeostasis. Hormone Research, 62(Suppl 1), 77–82. https://doi.org/10.1159/000080763

21.

Demirci

Şan

Irmak

Özmen

Kiliç

(2018). Neuropeptide-Y, leptin and ghrelin levels in children with ADHD: Effects of methylphenidate treatment. Anatolian Journal of Psychiatry, 19(5), 1. https://doi.org/10.5455/apd.289575

22.

Donga

Van Dijk

J. G.

Biermasz

N. R.

Lammers

G. J.

Van Kralingen

K. W.

Corssmit

E. P.

Romijn

J. A.

(2010). A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. Journal of Clinical Endocrinology and Metabolism, 95(6), 2963–2968. https://doi.org/10.1210/jc.2009-2430

23.

Du Rietz

Brikell

Butwicka

Leone

Chang

Cortese

D’Onofrio

B. M.

Hartman

C. A.

Lichtenstein

Faraone

S. V.

Kuja-Halkola

Larsson

(2021). Mapping phenotypic and aetiological associations between ADHD and physical conditions in adulthood in Sweden: A genetically informed register study. The Lancet Psychiatry, 8(9), 774–783. https://doi.org/10.1016/S2215-0366(21)00171-1

24.

DuPaul

G. J.

Power

T. J.

Anastopoulos

A. D.

Reid

(1998). ADHD Rating Scale—IV: Checklists, norms, and clinical interpretation. Guilford Press. https://psycnet.apa.org/record/1998-06605-000

25.

Facer-Childs

E. R.

Middleton

Skene

D. J.

Bagshaw

A. P.

(2019). Resetting the late timing of ‘night owls’ has a positive impact on mental health and performance. Sleep Medicine, 60, 236–247. https://doi.org/10.1016/j.sleep.2019.05.001

26.

Friedrich

Thuesen

Jrøgensen

Juul

Spielhagen

Wallaschofksi

Linneberg

(2012). The association between IGF-I and insulin resistance: A general population study in Danish adults. Diabetes Care, 35(4), 768–773. https://doi.org/10.2337/dc11-1833

27.

Gangwisch

J. E.

(2009). Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obesity Reviews, 10, 37–45. https://doi.org/10.1111/j.1467-789X.2009.00663.x

28.

Gurbuz

B. B.

Celik

G. G.

Yildirim

Ucakturk

S. A.

Seydaoglu

Ucakturk

E. M.

Topaloglu

A. K.

Yuksel

(2016). Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder. Journal of Pediatric Endocrinology and Metabolism, 29(1), 85–92. https://doi.org/10.1515/jpem-2015-0171

29.

Hanlon

E. C.

Van Cauter

(2011). Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism. Proceedings of the National Academy of Sciences USA, 108(supplement_3), 15609–15616. https://doi.org/10.1073/pnas.1101338108

30.

Hirvikoski

Lindholm

Nordenström

Nordström

A. L.

Lajic

(2009). High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder). Hormones and Behavior, 55(3), 418–424. https://doi.org/10.1016/j.yhbeh.2008.12.004

31.

Hsu

J. W.

Huang

K. L.

Y. M.

Tsai

S. J.

Chen

M. H.

(2023). Role of appetite hormone dysregulation in symptomology and executive function in adolescents with attention deficit hyperactivity disorder. International Journal of Neuropsychopharmacology, 26(2), 91–96. https://doi.org/10.1093/ijnp/pyac067

32.

Hvolby

(2015). Associations of sleep disturbance with ADHD: Implications for treatment. Attention Deficit and Hyperactivity Disorders, 7(1), 1–18. https://doi.org/10.1007/s12402-014-0151-0

33.

Instanes

J. T.

Klungsøyr

Halmøy

Fasmer

O. B.

Haavik

(2018). Adult ADHD and comorbid somatic disease: A systematic literature review. Journal of Attention Disorders, 22(3), 203–228. https://doi.org/10.1177/1087054716669589

34.

Işeri

Kiliç

B. G.

Şenol

Karabacak

N. I.

(2007). Effects of methylphenidate on leptin and appetite in children with attention-deficit hyperactivity disorder: An open label trial. Methods and Findings in Experimental and Clinical Pharmacology, 29(1), 47–52. https://doi.org/10.1358/mf.2007.29.1.1063491

35.

Knutson

K. L.

(2010). Sleep duration and cardiometabolic risk: A review of the epidemiologic evidence. Best Practice and Research: Clinical Endocrinology and Metabolism, 24(5), 731–743. https://doi.org/10.1016/j.beem.2010.07.001

36.

Kooij

(2013). Adult ADHD: Diagnostic assessment and treatment (3rd ed.). Springer-Verlag Publishing.

37.

Kooij

J. J. S.

Buitelaar

J. K.

van den Oord

E. J.

Furer

J. W.

Rijnders

C. A. T.

Hodiamont

P. P. G.

(2005). Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychological Medicine, 35(6), 817–827. https://doi.org/10.1017/S003329170400337X

38.

Kudielka

B. M.

Federenko

I. S.

Hellhammer

D. H.

Wüst

(2006). Morningness and eveningness: The free cortisol rise after awakening in “early birds” and “night owls.” Biological Psychology, 72(2), 141–146. https://doi.org/10.1016/j.biopsycho.2005.08.003

39.

Lack

L. C.

Wright

H. R.

(2007). Clinical management of delayed sleep phase disorder. Behavioral Sleep Medicine, 5(1), 57–76. https://doi.org/10.1080/15402000709336726

40.

Lackschewitz

Hüther

Kröner-Herwig

(2008). Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrinology, 33(5), 612–624. https://doi.org/10.1016/j.psyneuen.2008.01.016

41.

Leproult

Copinschi

Buxton

Van Cauter

(1997). Sleep loss results in an elevation of cortisol levels the next evening. Sleep, 20(10), 865–870. https://doi.org/10.1093/sleep/20.10.865

42.

Leproult

Van Cauter

(2011). Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA, 305(21), 2173–2174. https://doi.org/10.1001/jama.2011.709

43.

Lewy

A. J.

Bauer

V. K.

Ahmed

Thomas

K. H.

Cutler

N. L.

Singer

C. M.

Moffit

M. T.

Sack

R. L.

(1998). The Human Phase-Response Curve (PRC) to Melatonin is about 12 hours out of phase with the PRC to light. Chronobiology International, 15(1), 71–83. https://doi.org/10.3109/07420529808998671

44.

Lewy

A. J.

Sack

R. L.

(1989). The dim light melatonin onset as a marker for orcadian phase position. Chronobiology International, 6(1), 93–102. https://doi.org/10.3109/07420528909059144

45.

Miniksar

Gocmen

(2023). Comparison of leptin, leptin receptor, vitamin D and brain-derived neurotrophic factor levels in major depressive disorder and attention deficit and hyperactivity disorder in children and adolescents. Psychiatry and Behavioral Sciences, 13(2), 1. https://doi.org/10.5455/pbs.20220728103051

46.

Özcan

Ö.

Arslan

Güngör

Yüksel

Selimoğlu

M. A.

(2018). Plasma leptin, adiponectin, neuropeptide Y levels in drug naive children with ADHD. Journal of Attention Disorders, 22(9), 896–900. https://doi.org/10.1177/1087054715587095

47.

Penninx

B. W. J. H.

Milaneschi

Lamers

Vogelzangs

(2013). Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile. BMC Medicine, 11(1), 1–14. https://doi.org/10.1186/1741-7015-11-129

48.

Plat

Leproult

L’Hermite-Baleriaux

Fery

Mockel

Polonsky

K. S.

Van Cauter

(1999). Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. Journal of Clinical Endocrinology and Metabolism, 84(9), 3082–3092. https://doi.org/10.1210/jcem.84.9.5978

49.

Pruessner

J. C.

Kirschbaum

Meinlschmid

Hellhammer

D. H.

(2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28(7), 916–931. https://doi.org/10.1016/S0306-4530(02)00108-7

50.

Qian

Morris

C. J.

Caputo

Garaulet

Scheer

F. A. J. L.

(2019). Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. International Journal of Obesity, 43(8), 1644–1649. https://doi.org/10.1038/s41366-018-0208-9

51.

Ramos-Quiroga

J. A.

Corominas-Roso

Palomar

Ferrer

Valero

Corrales

Richarte

Casas

(2016). Cortisol awakening response in adults with attention deficit hyperactivity disorder: Subtype differences and association with the emotional lability. European Neuropsychopharmacology, 26(7), 1140–1149. https://doi.org/10.1016/j.euroneuro.2016.03.014

52.

Randler

Schaal

(2010). Morningness-eveningness, habitual sleep-wake variables and cortisol level. Biological Psychology, 85(1), 14–18. https://doi.org/10.1016/j.biopsycho.2010.04.006

53.

Raz

Leykin

(2015). Psychological and cortisol reactivity to experimentally induced stress in adults with ADHD. Psychoneuroendocrinology, 60, 7–17. https://doi.org/10.1016/j.psyneuen.2015.05.008

54.

Reda

M. M.

El-Hadidyb

(2011). Serum leptin in children with attention deficit hyperactivity disorder. Middle East Current Psychiatry, 18(1), 1–5. https://doi.org/10.1097/01.XME.0000392841.86983.cd

55.

Revell

V. L.

Burgess

H. J.

Gazda

C. J.

Smith

M. R.

Fogg

L. F.

Eastman

C. I.

(2006). Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. Journal of Clinical Endocrinology and Metabolism, 91(1), 54–59. https://doi.org/10.1210/jc.2005-1009

56.

Reynolds

A. C.

Dorrian

Liu

P. Y.

van Dongen

H. P. A.

Wittert

G. A.

Harmer

L. J.

Banks

(2012). Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men. PLoS One, 7(7), e41218. https://doi.org/10.1371/journal.pone.0041218

57.

Rijksinstituut voor Volksgezondheid en Milieu. (2022). Gezond gewicht. Retrieved September 19, 2024, from https://www.rivm.nl/leefstijlmonitor/gezond-gewicht

58.

Sahin

Yuce

Alacam

Karabekiroglu

Say

G. N.

Salis

(2014). Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder. International Journal of Psychiatry in Clinical Practice, 18(4), 280–287. https://doi.org/10.3109/13651501.2014.940054

59.

Scheer

F. A. J. L.

Morris

C. J.

Shea

S. A.

(2013). The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity, 21(3), 421–423. https://doi.org/10.1002/oby.20351

60.

Schmid

S. M.

Hallschmid

Jauch-Chara

Wilms

Lehnert

Born

Schultes

(2011). Disturbed glucoregulatory response to food intake after moderate sleep restriction. Sleep, 34(3), 371–377. https://doi.org/10.1093/sleep/34.3.371

61.

Shan

Xie

Yan

Guo

Bao

Rong

Jackson

C. L.

F. B.

Liu

(2015). Sleep duration and risk of type 2 diabetes: A meta-analysis of prospective studies. Diabetes Care, 38(3), 529–537. https://doi.org/10.2337/dc14-2073

62.

Sheehan

D. V.

Lecrubier

Sheehan

K. H.

Amorim

Janavs

Weiller

Hergueta

Baker

Dunbar

G. C.

(1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry, 59(Suppl 20), 22–33. https://psycnet.apa.org/record/1998-03251-004

63.

Sinha

M. K.

Ohannesian

J. P.

Heiman

M. L.

Kriauciunas

Stephens

T. W.

Magosin

Marco

Caro

J. F.

(1996). Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. Journal of Clinical Investigation, 97(5), 1344–1347. https://doi.org/10.1172/JCI118551

64.

Spiegel

Knutson

Leproult

Tasali

Van Cauter

(2005). Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes. Journal of Applied Physiology, 99(5), 2008–2019. https://doi.org/10.1152/japplphysiol.00660.2005

65.

Spiegel

Leproult

Van Cauter

(1999). Impact of sleep debt on metabolic and endocrine function. The Lancet, 354(9188), 1435–1439. https://doi.org/10.1016/S0140-6736(99)01376-8

66.

Spiegel

Tasali

Penev

Van Cauter

(2004). Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Yearbook of Endocrinology, 141(11), 846–850. https://doi.org/10.1016/s0084-3741(08)70348-2

67.

Stamatakis

K. A.

Punjabi

N. M.

(2010). Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest, 137(1), 95–101. https://doi.org/10.1378/chest.09-0791

68.

Stolk

R. P.

Orchard

T. J.

Grobbee

D. E.

(1995). Why use the oral glucose tolerance test? Diabetes Care, 18(7), 1045–1049. https://doi.org/10.2337/diacare.18.7.1045

69.

Terman

J. S.

Terman

E.-S.

Cooper

T. B.

(2001). Circadian time of morning light administration and therapeutic response in winter depression. Archives of General Psychiatry, 58(1), 69–75. https://doi.org/10.1001/archpsyc.58.1.69

70.

Timper

Brüning

J. C.

(2017). Hypothalamic circuits regulating appetite and energy homeostasis: Pathways to obesity. DMM Disease Models and Mechanisms, 10(6), 679–689. https://doi.org/10.1242/dmm.026609

71.

Van Andel

Bijlenga

Vogel

S. W. N.

Beekman

A. T. F.

Kooij

J. J. S.

(2021). Effects of Chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: A randomized clinical trial. Chronobiology International, 38(2), 260–269. https://doi.org/10.1080/07420528.2020.1835943

72.

Van Andel

Bijlenga

Vogel

S. W. N.

Beekman

A. T. F.

Kooij

J. J. S.

(2022). Attention-deficit/hyperactivity disorder (ADHD) and delayed sleep phase syndrome (DSPS) in adults: A randomised clinical trial on the effects of chronotherapy on sleep. Journal of Biological Rhythms, 37(6), 673–689. https://doi.org/10.1177/07487304221124659

73.

Van Cauter

(1989). Endocrine rhythms. In J. Arendt, D. S. Minors, & J. M. Waterhouse (Eds.), Biological Rhythms in clinical practice (pp. 23–50). London: Wright. https://medtextfree.wordpress.com/2011/12/19/chapter-6-endocrine-rhythms/

74.

Van Cauter

Polonsky

K. S.

Scheen

A. J.

(1997). Roles of circadian rhythmicity and sleep in human glucose regulation. Endocrine Reviews, 18(5), 716–738. https://doi.org/10.1210/er.18.5.716

75.

Van der Lely

A. J.

Tschöp

Heiman

M. L.

Ghigo

(2004). Biological, physiological, pathophysiological, and pharmacological aspects of Ghrelin. Endocrine Reviews, 25(3), 426–457. https://doi.org/10.1210/er.2002-0029

76.

Van der Voorn

Martens

Peppelman

Rotteveel

Blankenstein

Finken

Heijboer

(2015). Determination of cortisol and cortisone in human mother’s milk. Clinica Chimica Acta, 444(0), 154–155. https://www.publicatie-online.nl/files/7315/1384/7683/14786_BvdVoorn_FLP.pdf#page=69

77.

Van Leeuwen

W. M. A.

Hublin

Sallinen

Härmä

Hirvonen

Porkka-Heiskanen

(2010). Prolonged sleep restriction affects glucose metabolism in healthy young men. International Journal of Endocrinology, 2010, 108641. https://doi.org/10.1155/2010/108641

78.

Van Veen

M. M.

Kooij

J. J. S.

Boonstra

A. M.

Gordijn

M. C. M.

Van Someren

E. J. W.

(2010). Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia. Biological Psychiatry, 67(11), 1091–1096. https://doi.org/10.1016/j.biopsych.2009.12.032

79.

Van Vliet

I. M.

Leroy

Van Megen

H. J. G. M.

(2000). MINI plus: MINI internationaal neuropsychiatrisch interview: Dutch version 5.0.0. LUMC.

80.

Vogel

S. W. N.

Bijlenga

Verduijn

Bron

T. I.

Beekman

A. T. F.

Kooij

J. J. S.

Penninx

B. W. J. H.

(2017). Attention-deficit/hyperactivity disorder symptoms and stress-related biomarkers. Psychoneuroendocrinology, 79, 31–39. https://doi.org/10.1016/j.psyneuen.2017.02.009

81.

Vreeburg

S. A.

Kruijtzer

B. P.

van Pelt

van Dyck

DeRijk

R. H.

Hoogendijk

W. J. G.

Smit

J. H.

Zitman

F. G.

Penninx

B. W. J. H.

(2009). Associations between sociodemographic, sampling and health factors and various salivary cortisol indicators in a large sample without psychopathology. Psychoneuroendocrinology, 34(8), 1109–1120. https://doi.org/10.1016/j.psyneuen.2009.04.024

82.

Wauters

Considine

R. V

Gaal

L. F. Van

. (2000). Human leptin: From adipocyte hormone to an endocrine mediator. European Journal of Endocrinology, 143, 293–311. https://doi.org/10.1530/eje.0.1430293

83.

Wittmann

Dinich

Merrow

Roenneberg

(2006). Social jetlag: Misalignment of biological and social time. Chronobiology International, 23(1–2), 497–509. https://doi.org/10.1080/07420520500545979

84.

Liu

Yang

Snetselaar

L. G.

Jing

(2021). Association of attention-deficit/hyperactivity disorder with diabetes mellitus in US adults. Journal of Diabetes, 13(4), 299–306. https://doi.org/10.1111/1753-0407.13107

85.

Zhu

Shi

Park

C. G.

Zhao

Reutrakul

(2019). Effects of sleep restriction on metabolism-related parameters in healthy adults: A comprehensive review and meta-analysis of randomized controlled trials. Sleep Medicine Reviews, 45, 18–30. https://doi.org/10.1016/j.smrv.2019.02.002

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