This study aimed to evaluate the efficacy of sour cherry concentrate in symptoms of Attention Deficit Hyperactivity Disorder (ADHD).
Methods:
In a randomized clinical trial, 70 children with ADHD referred to the psychiatric clinic of Ibn-e-Sina Hospital, Mashhad, Iran, in 2021 were selected. Patients were randomly divided into two groups. The intervention group received 75 ml of sour cherry concentrate twice daily in addition to the routine treatment for 2 weeks. The patients were evaluated using The Conner’s Parent Rating Scale (CPRS) before and after the study by a psychiatry resident.
Results:
Based on the findings, no significant differences were observed between the groups in change percent of Cognitive impairments (p = .317), Hyperactivity/impulsivity (p = .525), Oppositional (p = .986), and ADHD index (p = .451). Moreover, 28.6% and 31.4% of children with ADHD consuming the concentrate presented abdominal pain, and asthenia, respectively.
Conclusion:
The present study did not indicate a beneficial effect of sour cherry concentrate on symptoms of ADHD.
AkhondzadehS.MohammadiM. R.KhademiM. (2004). Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry, 4, 9.
2.
AkhondzadehS.TavakolianR.Davari-AshtianiR.ArabgolF.AminiH. (2003). Selegiline in the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 27(5), 841–845.
3.
Alvarez-ArellanoL.González-GarcíaN.Salazar-GarcíaM.CoronaJ. C. (2020). Antioxidants as a potential target against inflammation and oxidative stress in attention-Deficit/hyperactivity disorder. Antioxidants, 9, 176.
4.
AmiriS.MohammadiM. R.MohammadiM.NouroozinejadG. H.KahbaziM.AkhondzadehS. (2008). Modafinil as a treatment for attention-deficit/Hyperactivity Disorder in children and adolescents: A double blind, randomized clinical trial. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32(1), 145–149.
5.
BellP. G.WalsheI. H.DavisonG. W.StevensonE.HowatsonG. (2014). Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling. Nutrients, 6(2), 829–843.
6.
BiedermanJ.SpencerT.WilensT. (2004). Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. The International Journal of Neuropsychopharmacology, 7(1), 77–97.
7.
CaldwellK.CharltonK. E.RoodenrysS.JennerA. (2016). Anthocyanin-rich cherry juice does not improve acute cognitive performance on RAVLT. Nutritional Neuroscience, 19(9), 423–424.
8.
ChaiS. C.JerusikJ.DavisK.WrightR. S.ZhangZ. (2019). Effect of Montmorency tart cherry juice on cognitive performance in older adults: A randomized controlled trial. Food & Function, 10, 4423–4431.
9.
ConnersC. K. (2001). Conners’ rating scales revised. Multi-Health Systems, Incorporated.
10.
DunnG. A.NiggJ. T.SullivanE. L. (2019). Neuroinflammation as a risk factor for attention deficit hyperactivity disorder. Pharmacology Biochemistry and Behavior, 182, 22–34.
11.
FaraoneS. V. (2009). Using meta-analysis to compare the efficacy of medications for attention-deficit/hyperactivity disorder in youths. Pharmacy and Therapeutics, 34(12), 678.
12.
FerrettiG.BacchettiT.BelleggiaA.NeriD. (2010). Cherry antioxidants: From farm to table. Molecules, 15(10), 6993–7005.
13.
HomokiJ. R.NemesA.FazekasE.GyémántG.BaloghP.GálF.Al-AsriJ.MortierJ.WolberG.BabinszkyL.RemenyikJ. (2016). Anthocyanin composition, antioxidant efficiency, and α-amylase inhibitor activity of different Hungarian sour cherry varieties (Prunus cerasus L.). Food Chemistry, 194, 222–229.
14.
HowatsonG.BellP. G.TallentJ.MiddletonB.McHughM. P.EllisJ. (2012). Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. European Journal of Nutrition, 51(8), 909–916.
15.
KahbaziM.GhoreishiA.RahiminejadF.MohammadiM. R.KamalipourA.AkhondzadehS. (2009). A randomized, double-blind and placebo-controlled trial of modafinil in children and adolescents with attention deficit and hyperactivity disorder. Psychiatry Research, 168(3), 234–237.
16.
KeaneK. M.Haskell-RamsayC. F.VeaseyR. C.HowatsonG. (2016). Montmorency tart cherries (Prunus cerasus L.) modulate vascular function acutely, in the absence of improvement in cognitive performance. British Journal of Nutrition, 116(11), 1935–1944.
17.
KelleyD. S.AdkinsY.LaugeroK. D. (2018). A review of the health benefits of cherries. Nutrients, 10, 368.
18.
KentK.CharltonK.RoodenrysS.BatterhamM.PotterJ.TraynorV.GilbertH.MorganO.RichardsR. (2017). Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. European Journal of Nutrition, 56(1), 333–341.
19.
KimbleR.KeaneK. M.LodgeJ. K.CheungW.Haskell-RamsayC. F.HowatsonG. (2022). Polyphenol-rich tart cherries (Prunus Cerasus, cv Montmorency) improve sustained attention, feelings of alertness and mental fatigue and influence the plasma metabolome in middle-aged adults: A randomised, placebo-controlled trial. British Journal of Nutrition. Advance online publication. https://doi.org/10.1017/S0007114522000460.
20.
KimD. O.HeoH. J.KimY. J.YangH. S.LeeC. Y. (2005). Sweet and sour cherry phenolics and their protective effects on neuronal cells. Journal of Agricultural and Food Chemistry, 53(26), 9921–9927.
21.
LeffaD.TorresI. S.RohdeL. (2018). A review on the role of inflammation in attention-deficit/hyperactivity disorder. Neuroimmunomodulation, 25, 328–333.
22.
Le Phuong NguyenT.FenyvesiF.RemenyikJ.HomokiJ. R.GogolákP.BácskayI.FehérP.UjhelyiZ.VasváriG.VecsernyésM.VáradiJ. (2018). Protective effect of pure sour cherry anthocyanin extract on cytokine-induced inflammatory caco-2 monolayers. Nutrients, 10, 861.
23.
NielsenP. R.BenrosM. E.DalsgaardS. (2017). Associations between autoimmune diseases and attention-deficit/hyperactivity disorder: A nationwide study. Journal of the American Academy of Child and Adolescent Psychiatry, 56, 234–240.e1.
24.
Özen, İ.T.EkşiA. (2016). Melatonin and serotonin content of the main sour cherry varieties and commercially produced sour cherry concentrates. Eur Int J Sci Technol, 5(4), 57–64.
25.
PellowJ.SolomonE. M.BarnardC. N. (2011). Complementary and alternative medical therapies for children with attention-deficit/hyperactivity disorder (ADHD). Alternative Medicine Review: A Journal of Clinical Therapeutic, 16(4), 323–337.
26.
PigeonW. R.CarrM.GormanC.PerlisM. L. (2010). Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: A pilot study. Journal of Medicinal Food, 13(3), 579–583.
27.
PolanczykG.de LimaM. S.HortaB. L.BiedermanJ.RohdeL. A. (2007). The worldwide prevalence of ADHD: A systematic review and metaregression analysis. American Journal of Psychiatry, 164(6), 942–948.
28.
RowlesB. M.FindlingR. L. (2010). Review of pharmacotherapy options for the treatment of attention-deficit/hyperactivity disorder (ADHD) and ADHD-like symptoms in children and adolescents with developmental disorders.. Developmental Disabilities Research Reviews, 16(3), 273–282.
29.
ŞengülM.ErkayaT.ŞengülM.YildizH. (2012). The effect of adding sour cherry pulp into yoghurt on the physicochemical properties, phenolic content and antioxidant activity during storage. International Journal of Dairy Technology, 65(3), 429–436.
30.
SeymourE. M.WarberS. M.KirakosyanA.NoonK. R.GillespieB.UhleyV. E.WunderJ.UrcuyoD. E.KaufmanP. B.BollingS. F. (2014). Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics following whole tart cherry intake in healthy humans. Journal of Functional Foods, 11, 509–516.
31.
ShahaianA.ShahimS.BashahL. F. Y. (2007). Standardization, factor analysis, and reliability of short form, especially for parents of Conner’s rating scale for children 6 to 11 years old in shiraz. Journal of psychological studies, 3(3), 97–120. Persian.
32.
ThangthaengN.PouloseS. M.GomesS. M.MillerM. G.BielinskiD. F.Shukitt-HaleB. (2016). Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats. Age, 38, 393–404.
33.
TrebatickáJ.ĎuračkováZ. (2015). Psychiatric disorders and polyphenols: Can they be helpful in therapy?Oxidative Medicine & Cellular Longevity, 2015. 9
34.
VerlaetA. A. J.MaasakkersC. M.HermansN.SavelkoulH. F. J. (2018). Rationale for dietary antioxidant treatment of ADHD. Nutrients, 10(4), 405.
35.
WangH.NairM. G.StrasburgG. M.ChangY. C.BoorenA. M.GrayJ. I.DeWittD. L. (1999). Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. Journal of Natural Products, 62(2), 294–296.
