Objective: To examine recurrence and timing of maternal depression as predictors of depressive and conduct symptoms in children with and without ADHD. Method: Children aged 4 to 6 years (125 ADHD, 122 comparison) were followed over 8 years. Maternal depression was assessed annually. Youth depressive and conduct symptoms were assessed at ages 12 to 14. Results: Recurrence of maternal depression predicted youth depressive and conduct symptoms at ages 12 to 14; child ADHD moderated relations between recurrence of maternal depression and youth depressive (but not conduct) symptoms. Early adolescent exposure to maternal depression predicted age 12 to 14 depressive symptoms for all children. Exposure to maternal depression during early childhood, childhood, and early adolescence each independently predicted youth conduct symptoms. Conclusion: Recurrence and timing of maternal depression predict comorbid symptoms in early adolescents, particularly for youth with ADHD. Findings inform the prevention of comorbidities in children with ADHD where maternal depression is present. (J. of Att. Dis. XXXX; XX(X) XX-XX)
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., Rev.). Washington, DC: Author.
2.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
3.
BagnerD. M.PettitJ. W.LewinsohnP. M.SeeleyJ. R. (2010). Effect of maternal depression on child behavior: A sensitive period?Journal of the American Academy of Child & Adolescent Psychiatry, 49, 699-707.
4.
BiedermanJ.FaraoneS. V.KeenanK.BenjaminJ.KrifcherB.MooreC.. . . SpencerT. (1992). Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder: Patterns of comorbidity in probands and relatives in psychiatrically and pediatrically referred samples. Archives of General Psychiatry, 49, 728-738.
5.
BrennanP. A.HammenC.AndersenM. J.BorW.NajmanJ. M.WilliamsG. M. (2000). Chronicity, severity, and timing of maternal depressive symptoms: Relationships with child outcomes at age 5. Developmental Psychology, 36, 759-766.
6.
BrennanP. A.HammenC.KatzA. R.Le BrocqueR. M. (2002). Maternal depression, paternal psychopathology, and adolescent diagnostic outcomes. Journal of Consulting and Clinical Psychology, 70, 1075-1085.
7.
CampbellS. B.Morgan-LopezA. A.CoxM. J.McLoydV. C. (2009). A latent class analysis of maternal depressive symptoms over 12 years and offspring adjustment in adolescence. Journal of Abnormal Psychology, 118, 479-493.
8.
ChronisA. M.LaheyB. B.PelhamW. E.Jr.KippH. L.BaumannB. L.LeeS. S. (2003). Psychopathology and substance abuse in parents of young children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 1424-1432.
9.
ChronisA. M.LaheyB. B.PelhamW. E.Jr.WilliamsS. H.BaumannB. L.KippH.. . . RathouzP. J. (2007). Maternal depression and early positive parenting predict future conduct problems in young children with attention-deficit/hyperactivity disorder. Developmental Psychology, 43, 70-82.
10.
Chronis-TuscanoA.ClarkeT. L.O’BrienK. A.RaggiV. L.DiazY.MintzA. D.. . .LewinsohnP. (2013). Development and preliminary evaluation of an integrated treatment targeting parenting and depressive symptoms in mothers of children with attention-deficit/hyperactivity disorder. Journal of Consulting and Clinical Psychology, 81, 918-925.
11.
Chronis-TuscanoA.MolinaB. S. G.PelhamW. E.ApplegateB.DahlkeA.OvermyerM.LaheyB. B. (2010). Very early predictors of adolescent depression and suicide attempts in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 67, 1044-1051.
12.
CostelloE. J.MustilloS.ErkanliA.KeelerG.AngoldA. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837-844.
13.
DoughertyL. R.TolepM. R.SmithV. C.RoseS. (2013). Early exposure to parental depression and parenting: Associations with young offspring’s stress physiology and oppositional behavior. Journal of Abnormal Child Psychology, 41, 1299-1310.
14.
EliaJ.AmbrosiniP.BerrettiniW. (2008). ADHD characteristics: I. Concurrent co-morbidity patterns in children & adolescents. Child and Adolescent Psychiatry and Mental Health, 2, 1-9.
15.
FabianoG. A.PelhamW. E.Jr.WaschbuschD. A.GnagyE. M.LaheyB. B.ChronisA. M.. . . Burrows-MacLeanL. (2006). A practical measure of impairment: Psychometric properties of the Impairment Rating Scale in samples of children with attention deficit hyperactivity disorder and two school-based samples. Journal of Clinical Child and Adolescent Psychology, 35, 369-385.
16.
GajosJ. M.BeaverK. M. (2017). Maternal depression and risk for antisocial behaviour in children. Child & Family Social Work, 22, 349-363.
17.
GoodmanS. H.RouseM. H.ConnellA. M.BrothM. R.HallC. M.HeywardD. (2011). Maternal depression and child psychopathology: A meta-analytic review. Clinical Child and Family Psychology Review, 14, 1-27.
18.
GrahamJ. W.OlchowskiA. E.GilreathT. D. (2007). How many imputations are really needed? Some practical clarifications of multiple imputation theory. Prevention Science, 8, 206-213.
19.
HalliganS. L.MurrayL.MartinsC.CooperP. J. (2007). Maternal depression and psychiatric outcomes in adolescent offspring: A 13-year longitudinal study. Journal of Affective Disorders, 97, 145-154.
20.
HammertonG.ZammitS.MahedyL.PearsonR. M.SellersR.ThaparA.CollishawS. (2015). Pathways to suicide-related behavior in offspring of mothers with depression: The role of offspring psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 54, 385-393.
21.
HayD. F.PawlbyS.WatersC. S.PerraO.SharpD. (2010). Mothers’ antenatal depression and their children’s antisocial outcomes. Child Development, 81, 149-165.
22.
HayD. F.PawlbyS.WatersC. S.SharpD. (2008). Antepartum and postpartum exposure to maternal depression: Different effects on different adolescent outcomes. Journal of Child Psychology and Psychiatry, 49, 1079-1088.
23.
HuL.-t.BentlerP. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1-55.
24.
HumphreysK. L.KatzS. J.LeeS. S.HammenC.BrennanP. A.NajmanJ. M. (2013). The association of ADHD and depression: Mediation by peer problems and parent–child difficulties in two complementary samples. Journal of Abnormal Psychology, 122, 854-867.
25.
JamesA.LaiF.DahlC. (2004). Attention deficit hyperactivity disorder and suicide: A review of possible associations. Acta Psychiatrica Scandinavica, 110, 408-415.
26.
Kats-GoldI.PrielB. (2009). Emotion, understanding, and social skills among boys at risk of attention deficit hyperactivity disorder. Psychology in the Schools, 46, 658-678.
27.
KlineR. B. (2011). Principles and practice of structural equation modeling. New York, NY: Guilford Press.
28.
La GrecaA. M.HarrisonH. M. (2005). Adolescent peer relations, friendships, and romantic relationships: Do they predict social anxiety and depression?Journal of Clinical Child and Adolescent Psychology, 34, 49-61.
29.
LaheyB. B.PelhamW. E.SteinM. A.LoneyJ.TrapaniC.NugentK.. . . BaumannB. (1998). Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 695-702.
30.
LittleR. A. (1988). A test of missing completely at random for multivariate data with missing values. Journal of the American Statistical Association, 83, 1198-1202.
31.
MarsB.CollishawS.SmithD.ThaparA.PotterR.SellersR.. . . ThaparA. (2012). Offspring of parents with recurrent depression: Which features of parent depression index risk for offspring psychopathology?Journal of Affective Disorders, 136, 44-53.
32.
MarshalM. P.MolinaB. S.PelhamW. E.Jr. (2003). Childhood ADHD and adolescent substance use: An examination of deviant peer group affiliation as a risk factor. Psychology of Addictive Behaviors, 17, 293-302.
33.
MuthénL. K.MuthénB. O. (1998-2012). Mplus user’s guide (7th ed.). Los Angeles, CA: Author.
PearsonR. M.EvansJ.KounaliD.LewisG.HeronJ.RamchandaniP. G.. . . SteinA. (2013). Maternal depression during pregnancy and the postnatal period: Risks and possible mechanisms for offspring depression at age 18 years. JAMA Psychiatry, 70, 1312-1319.
36.
PelhamW. E.GnagyE. M.GreensladeK. E.MilichR. (1992). Teacher ratings of DSM-III-R symptoms for the disruptive behavior disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 31, 210-218.
37.
RaggiV. L.ChronisA. M. (2006). Interventions to address the academic impairment of children and adolescents with ADHD. Clinical Child and Family Psychology Review, 9, 85-111.
38.
PhillipsD. A.ShonkoffJ. P. (Eds.) (2000). From neurons to neighborhoods: The science of early childhood development. Washington, DC: National Academies Press.
39.
RichardsD. (2011). Prevalence and clinical course of depression: A review. Clinical Psychology Review, 31, 1117-1125.
40.
SatterfieldJ. H.FallerK. J.CrinellaF. M.SchellA. M.SwansonJ. M.HomerL. D. (2007). A 30-year prospective follow-up study of hyperactive boys with conduct problems: Adult criminality. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 601-610.
41.
ShafferD.Schwab-StoneM.FisherP. W.CohenP.PlacentiniJ.DaviesM.. . . RegierD. (1993). The Diagnostic Interview Schedule for Children-Revised version (DISC-R): I. Preparation, field testing, interrater reliability, and acceptability. Journal of the American Academy of Child & Adolescent Psychiatry, 32, 643-650.
42.
ShemmassianS. K.LeeS. S. (2015). Predictive utility of four methods of incorporating parent and teacher symptom ratings of ADHD for longitudinal outcomes. Journal of Clinical Child & Adolescent Psychology, 34, 1-12.
43.
SpitzerR.WilliamsJ.GibbonM.FirstM. (1990). User’s guide for the structured clinical interview for DSM-IV–R. Washington, DC: American Psychiatric Press.
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