Interaction Between Season of Birth and COMT Val158Met (rs4680) in ADHD in a Large Sample of Chinese Han Participants

Abstract

Objective: To investigate the interaction between catechol-O-methyltransferase gene (COMT) Val108/158Met (rs4680) and season of birth (SOB) on ADHD and its symptoms. Method: We conducted transmission disequilibrium tests (TDTs) in 976 trios, then further performed the above analyses in subgroups according to SOB. Quantitative analyses were performed for ADHD symptoms evaluated by ADHD Rating Scale–IV in 1,530 ADHD cases. Results: Overall, there was no association between COMT and ADHD. After stratification, we found an increased transmission of the Val allele in the trios born in spring, while a decreased transmission was observed in the autumn months. We also observed a significant interaction between Val108/158Met and SOB on ADHD symptoms. Among those born in spring, Met carriers had milder ADHD symptoms compared with Val homozygotes, whereas opposite association was found in those born in autumn. Conclusion: Our study provided evidence for the modifying effect of SOB on the association between COMT and ADHD along with its symptoms.

Keywords

ADHD season of birth interaction

Get full access to this article

View all access options for this article.

References

American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.

Amons

P. J.

Kooij

J. J.

Haffmans

P. M.

Hoffman

T. O.

Hoencamp

(2006). Seasonality of mood disorders in adults with lifetime attention-deficit/hyperactivity disorder (ADHD). Journal of Attention Disorders, 91, 251-255.

Badruzzaman

Bapary

M. A.

Takemura

(2013). Possible roles of photoperiod and melatonin in reproductive activity via changes in dopaminergic activity in the brain of a tropical damselfish, Chrysiptera cyanea. General and Comparative Endocrinology, 194, 240-247.

Barkley

R. A.

(1998). Attention-deficit hyperactivity disorder: A clinical workbook (2nd ed.). New York, NY: Guilford Press.

Barkley

R. A.

Fischer

Smallish

Fletcher

(2002). The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. American Psychological Association, 111, 279-289.

Biederman

Kim

J. W.

Doyle

A. E.

Mick

Fagerness

Smoller

J. W.

Faraone

S. V.

(2008). Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: A preliminary study. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B, 1511-1518.

Brookes

K. J.

Neale

Thapar

Gill

Langley

. . . Asherson

(2008). Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147B, 94-99.

Chotai

Adolfsson

(2002). Converging evidence suggests that monoamine neurotransmitter turnover in human adults is associated with their season of birth. European Archives of Psychiatry & Clinical Neuroscience, 252, 130-134.

10.

Chotai

Asberg

(1999). Variations in CSF monoamine metabolites according to the season of birth. Neuropsychobiology, 39, 57-62.

11.

Chotai

Joukamaa

Taanila

Lichtermann

Miettunen

(2009). Novelty seeking among adult women is lower for the winter borns compared to the summer borns: Replication in a large Finnish birth cohort. Comprehensive Psychiatry, 50, 562-566.

12.

Colzato

L. S.

van den Wildenberg

W. P.

Van der Does

A. J.

Hommel

(2010). Genetic markers of striatal dopamine predict individual differences in dysfunctional, but not functional impulsivity. Neuroscience, 170, 782-788.

13.

Crosbie

Perusse

Barr

C. L.

Schachar

R. J.

(2008). Validating psychiatric endophenotypes: Inhibitory control and attention deficit hyperactivity disorder. Neuroscience & Biobehavioral Reviews, 32, 40-55.

14.

Dennis

Francis

D. J.

Cirino

P. T.

Schachar

Barnes

M. A.

Fletcher

J. M.

(2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society, 15, 331-343.

15.

DeYoung

C. G.

Getchell

Koposov

R. A.

Yrigollen

C. M.

Haeffel

G. J.

K. B.

. . . Grigorenko

E. L.

(2010). Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. Psychiatric Genetics, 20, 20-24.

16.

Diaz-Asper

C. M.

Weinberger

D. R.

Goldberg

T. E.

(2006). Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics. The American Society for Experimental NeuroTherapeutics, 3, 97-105.

17.

Disanto

Morahan

J. M.

Lacey

M. V.

DeLuca

G. C.

Giovannoni

Ebers

G. C.

Ramagopalan

S. V.

(2012). Seasonal distribution of psychiatric births in England. PLoS ONE, 7, e34866.

18.

Eisenberg

D. T.

Campbell

Mackillop

Lum

J. K.

Wilson

D. S.

(2007). Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. PLoS ONE, 2, e1216.

19.

Esquifino

A. I.

Moreno

M. L.

Steger

R. W.

(1994). Effects of chronic melatonin administration on adrenal medulla catecholamine metabolism in adult male golden hamsters. Journal of Pineal Research, 16, 154-158.

20.

Fernell

Bejerot

Westerlund

Miniscalco

Simila

Eyles

. . . Humble

M. B.

(2015). Autism spectrum disorder and low vitamin D at birth: A sibling control study. Molecular Autism, 6, 3.

21.

Flight

M. H.

(2013). Synaptic transmission: Summer blues. Nature Reviews Neuroscience, 14, 378.

22.

Gauderman

W. J.

(2002). Sample size requirements for association studies of gene-gene interaction. American Journal of Epidemiology, 155, 478-484.

23.

Gizer

I. R.

Ficks

Waldman

I. D.

(2009). Candidate gene studies of ADHD: A meta-analytic review. Human Genetics, 126, 51-90.

24.

Goldman

B. D.

(2003). Pattern of melatonin secretion mediates transfer of photoperiod information from mother to fetus in mammals. Science’s STKE, 2003, PE29.

25.

Grytten

Torkildsen

Aarseth

J. H.

Benjaminsen

Celius

E. G.

Dahl

O. P.

. . . Kampman

M. T.

(2013). Month of birth as a latitude-dependent risk factor for multiple sclerosis in Norway. Multiple Sclerosis Journal, 19, 1028-1034.

26.

Hawi

Cummins

T. D.

Tong

Johnson

Lau

Samarrai

Bellgrove

M. A.

(2015). The molecular genetic architecture of attention deficit hyperactivity disorder. Molecular Psychiatry, 20, 289-297.

27.

Hong

S. B.

Zalesky

Park

Yang

Y. H.

Park

M. H.

Kim

. . . Kim

J. W.

(2014). COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder. Human Brain Mapping, 36, 367-377.

28.

Kamal

Bener

Ehlayel

M. S.

(2014). Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? Attention Deficit and Hyperactivity Disorders, 6, 73-78.

29.

Keller

M. C.

(2014). Gene x environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution. Biological Psychiatry, 75, 18-24.

30.

Kesby

J. P.

Cui

McGrath

J. J.

Burne

T. H.

Eyles

D. W.

(2009). Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain. Neuroscience Letters, 461, 155-158.

31.

Kowalyk

T. V.

Davis

Wattie

Baker

(2014). No link between date of birth and ADHD symptoms in adults. Journal of Attention Disorders, 18, 73-81.

32.

Lachman

H. M.

Papolos

D. F.

Saito

Y. M.

Szumlanski

C. L.

Weinshilboum

R. M.

(1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243-250.

33.

Larsson

Chang

D’Onofrio

B. M.

Lichtenstein

(2014). The heritability of clinically diagnosed attention deficit hyperactivity disorder across the lifespan. Psychological Medicine, 44, 2223-2229.

34.

Liederman

Flannery

K. A.

(1994). Fall conception increases the risk of neurodevelopmental disorder in offspring. Journal of Clinical and Experimental Neuropsychology, 16, 754-768.

35.

Livak

K. J.

(1999). Allelic discrimination using fluorogenic probes and the 5’ nuclease assay. Genetic Analysis, 14, 143-149.

36.

Malek

Amiri

Sadegfard

Abdi

Amini

(2012). Associated factors with attention deficit hyperactivity disorder (ADHD): A case-control study. Archives of Iranian Medicine, 15, 560-563.

37.

McGrath

J. J.

Barnett

A. G.

Eyles

D. W.

(2005). The association between birth weight, season of birth and latitude. Annals of Human Biology, 32, 547-559.

38.

Meyer-Lindenberg

Weinberger

D. R.

(2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience, 7, 818-827.

39.

Mick

Biederman

Faraone

S. V.

(1996). Is season of birth a risk factor for attention-deficit hyperactivity disorder? Journal of the American Academy of Child & Adolescent Psychiatry, 35, 1470-1476.

40.

Naber

Wirz-Justice

Kafka

M. S.

(1981). Circadian rhythm in rat brain opiate receptor. Neuroscience Letters, 21, 45-50.

41.

Nakamura

Tamura

Kashida

Takayama

Yamagata

Karube

. . . Kato

(2001). Changes of serum melatonin level and its relationship to feto-placental unit during pregnancy. Journal of Pineal Research, 30, 29-33.

42.

Nikolac

P. M.

Kiive

Nedic

E. G.

Veidebaum

Curkovic

Dodig-Curkovic

. . . Pivac

(2013). The association between the catechol-O-methyltransferase Val108/158Met polymorphism and hyperactive-impulsive and inattentive symptoms in youth. Psychopharmacology, 230, 69-76.

43.

Nikolac

P. M.

Nedic

E. G.

Stefulj

Muck-Seler

Pivac

Kocijan

H. D.

. . . Dodig-Curkovic

(2014). Association between the polymorphisms of the selected genes encoding dopaminergic system with ADHD and autism. Psychiatry Research, 215, 260-261.

44.

Paloyelis

Asherson

Mehta

M. A.

Faraone

S. V.

Kuntsi

(2010). DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. Neuropsychopharmacology, 35, 2414-2426.

45.

Pantazatos

S. P.

(2013). Prediction of individual season of birth using MRI. NeuroImage, 88C, 61-68.

46.

Qian

Wang

Zhou

Wang

Glatt

Faraone

S. V.

(2003). Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 118B, 103-109.

47.

Qian

Q. J.

Liu

Wang

Y. F.

Yang

Guan

L. L.

Faraone

S. V.

(2009). Attention Deficit Hyperactivity Disorder comorbid oppositional defiant disorder and its predominately inattentive type: Evidence for an association with COMT but not MAOA in a Chinese sample. Behavioral and Brain Functions, 5, 8.

48.

Reppert

S. M.

Weaver

D. R.

(1995). Melatonin madness. Cell, 83, 1059-1062.

49.

Reuter

Kirsch

Hennig

(2006). Inferring candidate genes for attention deficit hyperactivity disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS). Journal of Neural Transmission, 113, 929-938.

50.

Sagvolden

Sergeant

J. A.

(1998). Attention deficit/hyperactivity disorder—From brain dysfunctions to behaviour. Behavioural Brain Research, 94, 1-10.

51.

Salatino-Oliveira

Genro

J. P.

Guimaraes

A. P.

Chazan

Zeni

Schmitz

. . . Hutz

M. H.

(2012). Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD. Journal of Neural Transmission, 119, 729-733.

52.

Salatino-Oliveira

Genro

J. P.

Zeni

Polanczyk

G. V.

Chazan

Guimaraes

A. P.

. . . Hutz

M. H.

(2011). Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on oppositional symptoms in boys with attention-deficit/hyperactivity disorder. Biological Psychiatry, 70, 216-221.

53.

Seeger

Schloss

Schmidt

M. H.

Ruter-Jungfleisch

Henn

F. A.

(2004). Gene-environment interaction in hyperkinetic conduct disorder (HD + CD) as indicated by season of birth variations in dopamine receptor (DRD4) gene polymorphism. Neuroscience Letters, 366, 282-286.

54.

Soeiro-De-Souza

M. G.

Stanford

M. S.

Bio

D. S.

Machado-Vieira

Moreno

R. A.

(2013). Association of the COMT Met158 allele with trait impulsivity in healthy young adults. Molecular Medicine Reports, 7, 1067-1072.

55.

Sun

Yuan

Shen

Xiong

(2014). Role of COMT in ADHD: A systematic meta-analysis. Molecular Neurobiology, 49, 251-261.

56.

Takei

Sham

Callaghan

Glover

Murray

(1995). Early risk factors in schizophrenia: Place and season of birth. European Psychiatry, 10, 165-170.

57.

Voiculescu

S. E.

Zygouropoulos

Zahiu

C. D.

Zagrean

A. M.

(2014). Role of melatonin in embryo fetal development. Journal of Medicine and Life, 7, 488-492.

58.

Yang

Wang

(2014). Applying imaging genetics to ADHD: The promises and the challenges. Molecular Neurobiology, 50, 449-462.

59.

Yang

Wang

Y. F.

Qian

Q. J.

Biederman

Faraone

S. V.

(2004). DSM-IV subtypes of ADHD in a Chinese outpatient sample. Journal of the American Academy of Child & Adolescent Psychiatry, 43, 248-250.

60.

Young

J. B.

Shimano

(1998). Effects of rearing temperature on body weight and abdominal fat in male and female rats. American Journal of Physiology, 274, R398-R405.

61.

Zisapel

(2001). Melatonin-dopamine interactions: From basic neurochemistry to a clinical setting. Cellular and Molecular Neurobiology, 21, 605-616.

62.

Zisapel

Laudon

(1983). Inhibition by melatonin of dopamine release from rat hypothalamus: Regulation of calcium entry. Brain Research, 272, 378-381.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.04 MB