Objective: The aim of this study was to (a) test the usefulness of visuospatial working memory (VSWM) as an endophenotype for ADHD and (b) study the developmental trajectory of VSWM in ADHD. Method: A total of 110 ADHD patients, 60 unaffected siblings, and 109 controls, aged 8 to 29 years, were assessed on VSWM functioning. Multilevel analyses were carried out to account for the correlation between measurements within families. Results: ADHD patients showed impaired VSWM performance compared with unaffected siblings and controls, with comparable performance between unaffected siblings and controls. Impaired VSWM in ADHD patients was not more pronounced on higher memory loads, signifying executive rather than storage deficits as an underlying mechanism. ADHD patients, unaffected siblings, and controls showed parallel developmental trajectories of VSWM. Conclusion: Current findings question the usefulness of VSWM as a neurocognitive endophenotype for ADHD and provide unique insights into the developmental trajectory of VSWM in ADHD.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.
3.
BaddeleyA. (2003). Working memory: Looking back and looking forward. Nature Reviews. Neuroscience, 4, 829-839.
4.
BaddeleyA. (2007). Working memory, thought, and action. New York, NY: Oxford University Press.
5.
BaddeleyA. (2012). Working memory: Theories, models, and controversies. Annual Review of Psychology, 63, 1-29.
6.
BaddeleyA.BressiS.Della SalaS.LogieR.SpinnlerH. (1991). The decline of working memory in Alzheimer’s disease A longitudinal study. Brain, 114, 2521-2542.
7.
BaddeleyA.HitchG. (1974). Working memory. New York, NY: Academic Press.
8.
BarkleyR. A. (1990). Attention deficit hyperactivity disorder: A handbook for diagnosis and treatment. New York, NY: Guilford.
9.
BarkleyR. A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121(1), 65-94.
10.
BidwellL. C.WillcuttE. G.DefriesJ. C.PenningtonB. F. (2007). Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder. Biological Psychiatry, 62, 991-998.
11.
CastellanosF. X.TannockR. (2002). Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes. Nature Reviews Neuroscience, 3, 617-628.
12.
ConnersC. K.ErhardtD.SparrowE. P. (1999). Conner’s Adult ADHD Rating Scales: CAARS. North Tonawanda, NY:Multi-Health Systems.
13.
ConnersC. K.SitareniosG.ParkerJ. D. A.EpsteinJ. N. (1998a). Revision and restandardization of the Conners Teacher Rating Scale (CTRS-R): Factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology, 26, 279-291.
14.
ConnersC. K.SitareniosG.ParkerJ. D. A.EpsteinJ. N. (1998b). The revised Conners’ Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology, 26, 257-268.
15.
CroneE. A.WendelkenC.DonohueS.van LeijenhorstL.BungeS. A. (2006). Neurocognitive development of the ability to manipulate information in working memory. Proceedings of the National Academy of Sciences of the United States of America, 103, 9315-9320.
16.
DennisM.FrancisD. J.CirinoP. T.SchacharR.BarnesM. A.FletcherJ. M. (2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society, 15, 331-343.
17.
DowsonJ. H.McLeanA.BazanisE.TooneB.YoungS.RobbinsT. W.SahakianB. J. (2004). Impaired spatial working memory in adults with attention-deficit/hyperactivity disorder: Comparisons with performance in adults with borderline personality disorder and in control subjects. Acta Psychiatrica Scandinavica, 110, 45-54.
18.
GauS. S.ShangC. Y. (2010). Executive functions as endophenotypes in ADHD: Evidence from the Cambridge Neuropsychological Test Battery (CANTAB). Journal of Child Psychology and Psychiatry, 51, 838-849.
19.
GoldbergM. C.MostofskyS. H.CuttingL. E.MahoneE. M.AstorB. C.DencklaM. B.LandaR. J. (2005). Subtle executive impairment in children with autism and children with ADHD. [Research Support, N.I.H., Extramural Research Support, U.S. Gov’t, P.H.S.]. Journal of Autism and Developmental Disorders, 35, 279-293.
20.
GottesmanIIGouldT. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636-645.
21.
HalperinJ. M.SchulzK. P. (2006). Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychological Bulletin, 132, 560-581.
22.
KaratekinC. (2004). A test of the integrity of the components of Baddeley’s model of working memory in attention-deficit/hyperactivity disorder (ADHD). Journal of Child Psychology and Psychiatry, 45, 912-926.
23.
KasperL. J.AldersonR. M.HudecK. L. (2012). Moderators of working memory deficits in children with attention-deficit/hyperactivity disorder (ADHD): A meta-analytic review. Clinical Psychology Review, 605-617.
24.
KaufmanJ.BirmaherB.BrentD.RaoU.FlynnC.MoreciP.RyanN. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980-988.
25.
KlingbergT.ForssbergH.WesterbergH. (2002). Training of working memory in children with ADHD. Journal of Clinical and Experimental Neuropsychology, 24, 781-791.
26.
KoflerM. J.RapportM. D.BoldenJ.SarverD. E.RaikerJ. S. (2010). ADHD and working memory: The impact of central executive deficits and exceeding storage/rehearsal capacity on observed inattentive behavior. Journal of Abnormal Child Psychology, 38, 149-161.
27.
KooijJ. J.BuitelaarJ. K.van den OordE. J.FurerJ. W.RijndersC. A.HodiamontP. P. (2005). Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychological Medicine, 35, 817-827.
28.
LeboyerM.BellivierF.Nosten-BertrandM.JouventR.PaulsD.MalletJ. (1998). Psychiatric genetics: Search for phenotypes [Research Support, Non-U.S. Gov’t Review]. Trends in Neurosciences, 21, 102-105.
29.
MartinussenR.HaydenJ.Hogg-JohnsonS.TannockR. (2005). A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 377-384.
30.
McNabF.LerouxG.StrandF.ThorellL.BergmanS.KlingbergT. (2008). Common and unique components of inhibition and working memory: An fMRI, within-subjects investigation. Neuropsychologia, 46, 2668-2682.
31.
MüllerU. C.AshersonP.BanaschewskiT.BuitelaarJ. K.EbsteinR. P.EisenbergJ.SteinhausenH.-C. (2011). The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patterns. BMC Psychiatry, 11, 54.
32.
MurphyK.BarkleyR. A. (1996). Prevalence of DSM-IV symptoms of ADHD in adult licensed drivers: Implications for clinical diagnosis. Journal of Attention Disorders, 1, 147-161.
33.
PiekJ. P.PitcherT. M.HayD. A. (1999). Motor coordination and kinaesthesis in boys with attention deficit-hyperactivity disorder. Developmental Medicine & Child Neurology, 41, 159-165.
34.
PolanczykG.CaspiA.HoutsR.KollinsS. H.RohdeL. A.MoffittT. E. (2010). Implications of extending the ADHD age-of-onset criterion to age 12: Results from a prospectively studied birth cohort. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 210-216.
35.
RapportM. D.AldersonR. M.KoflerM. J.SarverD. E.BoldenJ.SimsV. (2008). Working memory deficits in boys with attention-deficit/hyperactivity disorder (ADHD): The contribution of central executive and subsystem processes. Journal of Abnormal Child Psychology, 36, 825-837.
36.
RapportM. D.BoldenJ.KoflerM. J.SarverD. E.RaikerJ. S.AldersonR. M. (2009). Hyperactivity in boys with attention-deficit/hyperactivity disorder (ADHD): A ubiquitous core symptom or manifestation of working memory deficits?Journal of Abnormal Child Psychology, 37, 521-534.
37.
RaudenbushS. W.BrykA. S. (2001). Hierarchical linear models: Applications and data analysis methods (Vol. 1). Thousand Oaks, CA: Sage.
38.
RommelseN. N. (2008). Endophenotypes in the genetic research of ADHD over the last decade: Have they lived up to their expectations?Expert Review of Neurotherapeutics, 8, 1425-1429.
39.
RommelseN. N.AltinkM. E.MartinN. C.BuschgensC. J.BuitelaarJ. K.SergeantJ. A.OosteriannJ. (2008). Neuropsychological measures probably facilitate heritability research of ADHD. Archives of Clinical Neuropsychology, 23, 579-591.
40.
RommelseN. N.AltinkM. E.OosterlaanJ.BuschgensC. J.BuitelaarJ.SergeantJ. A. (2008). Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychological Medicine, 38, 1595-1606.
41.
SeidmanL. J.BiedermanJ.MonuteauxM. C.WeberW.FaraoneS. V. (2000). Neuropsychological functioning in nonreferred siblings of children with attention deficit/hyperactivity disorder. Journal of Abnormal Psychology, 109, 252-265.
42.
Slaats-WillemseD.de SonnevilleL.Swaab-BarneveldH.BuitelaarJ. (2005). Motor flexibility problems as a marker for genetic susceptibility to attention-deficit/hyperactivity disorder. Biological Psychiatry, 58, 233-238.
43.
TabachnickB. G.FidellL. S. (2001). Using multivariate statistics (4th ed.). Needham Heights, MA: Allyn & Bacon.
44.
TillmanC.EningerL.ForssmanL.BohlinG. (2011). The relation between working memory components and ADHD symptoms from a developmental perspective. Developmental Neuropsychology, 36, 181-198.
45.
WillcuttE. G.DoyleA. E.NiggJ. T.FaraoneS. V.PenningtonB. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry, 57, 1336-1346.
