Andreazza, A.C., Frey, B.N., Valvassori, S.S., Zanotto, C., Gomes, K.M., Comim, C.M., . . . Gonçalves, C.A. (2007). DNA damage in rats after treatment with methylphenidate. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31, 1282-1288.
2.
Dobrovolsky, V.N., Boctor, S.Y., Twaddle, N.C., Doerge, D.R., Bishop, M.E., Manjanatha, M.G., . . . Ferguson, S. A. (2010). Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats . Environmental and Molecular Mutagenesis, 51, 138-145.
3.
El-Zein, R.A., Abdel-Rahman, S.Z., Hay, M.J., Lopez, M.S., Bondy, M.L., Morris, D.L., & Legator, M.S. ( 2005). Cytogenetic effects in children treated with methylphenidate . Cancer Letters, 230, 284-291.
4.
El-Zein, R.A., Hay, M.J., Lopez, M.S., Bondy, M.L., Morris, D.L., Legator, M.S., & Abdel-Rahman, S.Z. (2006). Response to comments on ‘Cytogenetic effects in children treated with methylphenidate’ by El-Zein et al. Cancer Letters, 231, 146-148.
5.
Goldstein, S. ( 2010). Chronic Ritalin use and cancer. Journal of Attention Disorders, 13, 441.
6.
Jacobson-Kram, D., Mattison, D., Shelby, M., Slikker, W., Tice, R., & Witt, K. ( 2008). Methylphenidate and chromosome damage. Cancer Letters, 260,: 216-218.
7.
Manjanatha, M.G., Shelton, S.D., Dobrovolsky, V.N., Shaddock, J.G., McGarrity, L.G., Doerge, D.R., . . .Morris, S.M. ( 2008). Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice. Environmental and Molecular Mutagenesis, 49, 585-593
8.
.
9.
Manjanatha, M.G., Shelton, S.D., Dobrovolsky, V.N., Shaddock, J.G., McGarrity, L.G., Twaddle, N.W., . . . Morris, S. M. (2009). Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks. Mutation Research, 680, 43-48.
10.
Morris, S.M., Dobrovolsky, V.N., Shaddock, J.G., Mittelstaedt, R.A., Bishop, M.E., Manjanatha, M.G., . . . Mattison, D. R. (2009). The genetic toxicology of methylphenidate hydrochloride in non-human primates. Mutation Research, 673, 59-66.
11.
Ntp-Cerhr (2005). NTP-CERHR monograph on the potential human reproductive and developmental effects of methylphenidate . (NIH Publication Number05-4473)
12.
Oestreicher, N., Friedman, G.D., Jiang, S.F., Chan, J., Quesenberry, C., Jr. , & Habel, L.A. (2007). Methylphenidate use in children and risk of cancer at 18 sites: Results of surveillance analyses . Pharmacoepidemiology and Drug Safety, 16, 1268-1272.
13.
Ponsa, I., Ramos-Quiroga, J.A., Ribasés, M., Bosch, R., Bielsa, A., Ordeig, M.T., . . . Hervás, A. (2009). Absence of cytogenetic effects in children and adults with attention-deficit/hyperactivity disorder treated with methylphenidate . Mutation Research, 666, 44-49.
14.
Rodriguez, J.S., Morris, S.M., Hotchkiss, C.E., Doerge, D.R., Allen, R.R., Mattison, D.R., & Paule, M.G. ( 2010). The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeys. Neurotoxicology and Teratology, 32, 142-151.
15.
Stopper, H., Walitza, S., Warnke, A., & Gerlach, M. ( 2008). Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate. Journal of Neural Transmission, 115, 331-334.
16.
Suter, W., Martus, H.J., & Elhajouji, A. ( 2006). Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. Mutation Research, 607, 153-159.
17.
Teo, S.K., San, R.H., Wagner, V.O., Gudi, R., Stirling, D.I., Thomas, S.D., & Khetani, V.D. ( 2003). D-Methylphenidate is non-genotoxic in in vitro and in vivo assays. Mutation Research, 537, 67-79.
18.
Tucker, J.D., Suter, W., Petibone, D.M., Thomas, R.A., Bailey, N.L., Zhou, Y., . . . Kumar, V. (2009). Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder . Mutation Research, 677, 53-58.
19.
Walitza, S., Kämpf, K., Artamonov, N., Romanos, M., Gnana Oli R., Wirth, S., . . . Stopper, H. ( 2009). No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy . Toxicology Letters, 184, 38-43.
20.
Walitza, S., Kämpf, K., Oli, R.G., Warnke, A., Gerlach, M., & Stopper, H. ( 2010). Prospective follow-up studies found no chromosomal mutagenicity of methylphenidate therapy in ADHD affected children. Toxicology Letters, 4-8.
21.
Walitza, S., Werner, B., Romanos, M., Warnke, A., Gerlach, M., & Stopper, H. ( 2007). Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder? Environmental Health Perspectives, 115, 936-940.
22.
Witt, K.L., Malarkey, D.E., Hobbs, C.A., Davis, J.P., Kissling, G.E., Caspary, W., . . . Recio, L. ( 2010). No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environmental and Molecular Mutagenesis, 51, 80-88.
23.
Witt, K.L., Shelby, M.D., Itchon-Ramos, N., Faircloth, M., Kissling, G.E., Chrisman, A.K., . . . Kollins, S.H. ( 2008). Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 1375-1383.
24.
Zito, J.M., & Safer, D.J. ( 2007). Is there a connection between methylphenidate and cancer in youth? Pharmacoepidemiology and Drug Safety, 16, 1273-1274.
