Abstract
Ultrasound-assisted radiopharmaceutical therapy (U-RPT) represents an emerging frontier in noninvasive cancer treatment, combining targeted radionuclide delivery with focused acoustic energy to enhance intratumoral drug uptake and therapeutic precision. Despite promising preclinical and translational outcomes, clinical implementation remains limited by procedural risks and variability in patient monitoring. In this prospective study involving 80 patients with solid tumors, we evaluated a structured nurse-coordinated care model during U-RPT to improve safety and procedural efficiency. The protocol incorporated predefined checkpoints for real-time physiological monitoring and adaptive intervention during sonication. Compared with standard care, nurse coordination resulted in significantly greater hemodynamic stability (p < 0.05), a 2-h reduction in recovery time (p < 0.01), and higher patient satisfaction scores (p < 0.001), while reducing the frequency of moderate and severe adverse events (p < 0.01). Predictive modeling identified heart rate variability and oxygen desaturation as key predictors of clinical risk (AUC = 0.74). These findings establish nurse-coordinated oversight as a critical adjunct to ultrasound-based radiopharmaceutical therapy, reinforcing the clinical safety, translational feasibility, and patient-centered potential of next-generation ultrasound oncology trials.
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