RisdonRA, SloperJC, De WardenerH.Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet1968;2:363–6.
WehrmannM, BohleA, HeldH, SchummG, KendziorraH, PresslerH.Long-term prognosis of focal sclerosing glomerulonephritis. An analysis of 250 cases with particular regard to tubulointerstitial changes. Clin Nephrol1990;33:115–22.
7.
AbeS, AmagasakiY, IyoriS, KonishiK, KatoE, SakaguchiH.Significance of tubulointerstitial lesions In biopsy specimens of glomerulonephritis patients. Am J Nephrol1989;9:30–7.
8.
BohleA, WehrmannM, BogenschutzO, BatzC, MullerCA. The pathogenesis of chronic renal failure in diabetic nephropathy. Path Res Pract1991;187:251–9.
9.
D'AmicoG.Influence of clinical and histological features on actuarial renal survival in adult patients with idiopathic IgA nephropathy, membranous nephropathy, and membranoproliferative glomerulonephritis: survey of the recent literature. Am J Kidney Dis1992;20:315–23.
10.
OkudaS, LanguinoLR, RuoslahtiE, BorderWA. Elevated expression of transforming growth factor-a and pProteoglycan pProduction in experimental glomerulonephritis. J Clin Invest1990;86:453–62.
11.
YamamotoT, NobleNA, MillerDE, BorderWA. Sustained expression of TGF-B1 underlies development of progressive kidney fibrosis. Kidney Int1994;45:916–27.
AndersonS, DiamondJR, KarnovskyMJ, BrennerBM. Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome. J Clin Invest1988;82:1757–68.
14.
D-AmicoG, FerrarioF, RastaldiMP. Tubulointerstitial damage in glomerular diseases: its role in the progression of renal damage. Am J Kidney Dis1995;26:124–32.
15.
Stein-OakleyAN, MaguireJA, DowlingJ, PerryG, ThomsonNM. Altered expression of fibrogenic growth factors in IgA nephropathy and focal and segmental glomerulosclerosis. Kidney Int1997;51:195–204.
16.
HookeDH, GeeDC, AtkinsRC. Leukocyte analysis using monoclonal antibodies in human glomerulonephritis. Kidney Int1987;31:964–72.
17.
BrunatiC, BrandoB, ConfalonieriR, BelliLS, LavagniMG, MinettiL.Immunophenotyping of mononuclear cell infiltrates associated with renal disease. Clin Nephrol1986;26:15–20.
18.
BoucherA, DrozD, AdaferE, NoelL.Characterization of mononuclear cell subsets in renal cellular interstitial infiltrates. Kidney Int1986;29:1043–9.
19.
KliemV, JohnsonRJ, AlpersCE, YoshimuraA, CouserWG, KochKM, FloegeJ.Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kidney Int1996;49:666–78.
20.
DiamondJR, Kees-FoltsD, DingG, FryeJE, RestrepoNC. Macrophages, monocyte chemattractant peptide-1, and TGF-β1 in experimental hydronephrosis. Am J Physiol1994;266:F926–33.
AlexopoulosE, SeronD, HartleyRB, NolascoF, CameronS.Immune mechanisms in idiopathic membranous nephropathy: the role of the interstitial infiltrates. Am J Kidney Dis1989;13:404–12.
23.
AlexopoulosE, SeronD, HartleyRB, CameronJS: Lupus Nephritis. Correlation of interstitial cells with glomerular function. Kidney Int1990;37:100–9.
24.
SchmouderRL, StrieterRM, KunkelSL. Interferon-gama regulation of human renal cortical epithelial cell derived monocyte chemotactic peptide-1. Kidney Int1993;44:43–9.
25.
TaubDD, ProostP, MurphyWJ, AnverM, LongoDL, Van DammeJ, OppenheimJJ. Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T Lymphocytes. J Clin Invest1995;95:1370–6.
26.
JiangY, BellerDI, FrendlG, GravesDT. Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes. J Immunol1992;148:2423–8.
27.
ProdjosudjadiW, GerritsmaJSJ, Klar-MohamadN, GerritsenAF, BruijnJA, DahaMR, Van esLA. Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells. Kidney Int1995;48:1477–86.
28.
GrandalianoG, GesualdoL, RanieriE, MonnoR, MontinaroV, MarraG, SchenaFP. Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: a pathogenetic role in interstitial monocyte recruitment. J Am Soc Nephrol1996;7:906–13.
29.
EddyAA, GiachelliCM. Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int1995;47:1546–57.
30.
PichlerR, GiachelliCM, LombardiD, PippinJ, GordonK, AlpersCE, SchwartzSM, JohnsonRJ. Tubulointerstitial fisease in glomerulonephritis. potential role of osteopontin (Uropontin). Am J Pathol1994;144:915–26.
BarisoniL, RadhakrishmanJ, D'AgatiV.Osteopontin mRNA and protein expression in glomerular disease correlates with tubulointerstitial damage. J Am Soc Nephrol1996;7:1751A.
33.
Kees-FoltsD, SadowJL, SchreinerGF. Tubular catabolism of albumin is associated with the release of an antiinflammatory lipid. Kidney Int1994;45:1697–709.
34.
ZojaC, MorigiM, FigliuzziM, BruzziI, OldroydS, BenigniA, RoncoP, RemuzziG.Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins. Am J Kidney Dis1995;26:934–41.
35.
HeegerP, WolfG, MeyersC, SunMJ, O'FarrellSC, KrenskyAM, NeilsonEG. Isolation and characterization of cDNA from renal tubular epithelium encoding murine rantes. Kidney Int1992;41:220–5.
36.
FrankJ, Engler-BlumG, RodemannH, MullerGA. Human renal tubular as a cytokine source. PDGF-B, GM-CSF, and IL-6 mRNA expression in vitro. Exp Nephrol1993;1:26–35.
37.
BurtonCJ, WallsJ.Proximal tubular cell, proteinuria and tubulointerstitial scarring. Nephron1994;68:287–93.
38.
OngACM, JowettTP, MoorheadJF, OwenJS. Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells. Kidney Int1994;46:1315–21.
39.
HanggonoT, RaoGS. Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers. Biochem & Biophys Res Comm1992;189:994–1000.
40.
BenigniA, RemuzziG.Glomerular protein trafficking and progression of renal disease to terminal uremia. Semin Nephrol 996;16:151–9.
41.
OrisioS, BenigniA, BruzziI, CornaD, PericoN, ZojaC, BenattiL, RemuzziG.Renal endothelin gene expression is increased in remnant kidney snd correlates with disease progression. Kidney Int1993;43:354–8.
WuthrichRP, GlimcherLH, YuiMA, JevnikarAM, DumasSE, KelleyVE. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int1990;37:783–92.
46.
SchmouderRL, StrieterRM, WigginsRC, ChensueSW, KunkelSL. In vitro and in vivo interleukin-8 production in human renal cortical epithelia. Kidney Int1992;41:191–8.
47.
BradyH.Leukocyte adhesion molecules and kidney diseases. Kidney Int1994;45:1285–1300.
48.
JevnikarAM, WuthrichRP, TakeiF, XuH, BrennanDC, GlimcherLH, Rubin-KelleyVE. Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells. Kidney Int1990:38:417–25.
49.
KelleyVR, Diaz-GalloC, JevnikarAM, SingerGG. Renal tubular epithelial and T cell interactions in autoimmune renal disease. Kidney Int1993;43 (39 Suppl):S108–15.
50.
MullerGA, Markovic-LipkovskiJ, MullerCA. Intracellular adhesion molecule-1 expression in human kidneys with glomerulonephritis. Clin Nephrol1991;36:203–8.
51.
MullerGA, Markovic-LipkovskiJ, RodemannHP. The progression of renal diseases: on the pathogenesis of renal interstitial fibrosis. Klim Wochenschr1991;69:576–86.
52.
HagertyDT, AllenPM. Processing and presentation of self and foreign antigens by the renal proximal tubule. J Immunol1992;148:2324–30.
53.
KellyCJ, RothDA, MeyersCM. Immune recognition and response to the renal interstitium. Kidney Int1991;31:518–30.
54.
Roy-ChaudhuryP, WuB, KingG, CampbellM, MacleodAM, HaitesNE, SimpsonJG, PowerDA. Adhesion molecule interactions in human glomerulonephritis importance of the tubulointerstitium. Kidney Int1996;49:127–34.
55.
HavertyTP, KellyCJ, HinesWH, AmentaPS, WatanabeM, HarperRA, KefalidesNA, NeilsonEG. Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol1988;107:1359–68.
56.
CreelyJJ, DiMariSJ, HoweAM, HaralsonMA. Effects of transforming growth factor-β on collagen synthesis by normal rat kidney epithelial cells. Am J Pathol1992;140: 45–55.
57.
BurtonCJ, CombeC, WallsJ, HarrisKPG. Fibronectin production by human tubular cells: the effect of apical protein. Kidney Int1996;50:760–7.
58.
StrutzF, OkadaH, LoCW, DanoffT, CaroneRL, TomaszewskiJE, NeilsonEG. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol1995;130:393–405.
59.
NadasdyT, LaszikZ, BlickKE, JohnsonDL, SilvaFG. Tubular atrophy in the end-stage kidney: a lectin and immunohistochemical study. Hum Pathol1994;25:22–8.
60.
CameronJS, TurnerDR, OggCS, ChantlerC, WilliamsDG. The long-term prognosis of patients with focal segmental glomerulosclerosis. Clini Nephrol1978;10:213–8.
61.
ErwinDT, DonadioJVJr, HolleyKE. The clinical course of idiopathic membranous nephropathy. Mayo Clin Proc1973;48:697–712.
62.
D'AmicoG, MinettiL, PonticelliC, FellinG, FerrarioF, Di BelgioiosoGB, ImbasciatiE, RagniA, BertoliS, FogazziG, et al. Prognostic indicators in idiopathic IgA mesangial nephropathy. QJM1986;59:363–378.
63.
RadfordMGJr, DonadioJVJr, BergstralhEJ, GrandeJP. Predicting renal outcome in IgA nephropathy. J Am Soc Nephrol1997;8:199–207.
KlahrS, LeveyAS, BeckGJ, CaggiulaAW, HunsickerL, KusekJW, StrikerG.The effects of dietary protein restriction and bloodpPressure control on the progression of chronic renal disease. N Engl J Med1994;330:877–84.
66.
CrokerBP, DawsonDV, SanfilippoF.IgA Nephropathy: correlation of clinical and histologic features. Lab Invest1983;48:19–24.
67.
OkadaK, FunaiM, KawakamiK, KagamiS, YanoI, KurodaY.IgA nephropathy in Japanese children and adults: a comparative study of clinicopathological features. Am J Nephrol1990;10:191–7.
68.
Widstam-AttorpsU, BergU, BohmanS, LefvertA.Proteinuria and renal function in relation to renal morphology. Clin Nephrol1992:38:245–53.
FogoA, BreyerJA, SmithMC, ClevelandWH, AgadoaL, KirkKA, GlassockR.Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report From the African American Study of Kidney Disease (AASK) trial. Kidney Int1997;51:244–52.
72.
AppelG.Renal involvement in systemic lupus. Medicine1978:57:371–410.
73.
MagilAB. Tubulointerstitial lesions in human membranous glomerulonephritis: relationship to proteinuria. Amer J Kidney Dis1995:25:375–9.
74.
HonkanenE, Gronhagen-RiskaC, von WillerbrandE, TornrothT, LaasonenL.Renal mononuclear inflammatory cell populations in membranous glomerulonephritis: A fine-needle aspiration biopsy study. Clin Nephrol1987:28:232–7.
75.
YoshiokaK, TakemuraT, MurakamiK, OkadaM, YagiK, MiyazatoH, MatsushimaK, MakiS.In situ expression of cytokines in IgA nephritis. Kidney Int1993;44:825–33.
76.
DiamondJR, AndersonS.Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis: amelioration by angiotensin I converting enzyme inhibition. Am J Pathol1990;137:1323–32.
77.
EddyAA, McCullochL, LiuE, AdamsJ.A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome. Am J Pathol1991;138:1111–23.
78.
EddyAA. Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol1989;135:719–33.
79.
FloegeJ, HackmannB, KliemV, KrizW, AlpersCE, JohnsonRJ, KuhnKW, KochK, BrunkhorstR.Age-related glomerulosclerosis and interstitial fibrosis in milan normotensive rats: a podocyte disease. Kidney Int1997;51:230–43.
80.
OlbrichtCJ, CannonJK, GargLC, TisherC.Activities of cathepsins B and L in isolated nephron segments from proteinuric and nonproteinuric rats. Am J Physiol1986;250:F1055–62.
81.
MaackT, JohnsonV, KauST, FigueiredoJ, SigulemD.Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review. Kidney Int1979;16:251–70.
82.
EddyAA, HoGC, ThornerPS. The contribution of antibody-mediated cytotoxicity and immune-complex formation to tubulointerstitial disease in passive Heymann nephritis. Clin Immunol Immunopathol1992;62:42–55.
83.
MendrickDL, NobleB, BrentjensJR, AndresGA. Antibody-mediated injury to proximal tubules in Heymann nephritis. Kidney Int1980;18:328–43.
84.
BrodkinM, NobleB.Antibody-mediated proliferation of proximal tubule cells. Clin Exp Immunol1988;71:107–12.
85.
RemuzziG, GiuseppeR, RuggenentiP, BenigniA.Understanding the nature of renal disease progression. Kidney Int1997;51:2–15.
86.
FeldSM, HirschbergR, ArtishevskyA, NastC, AdlerSG. Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney Int1995;48:45–51.
87.
EddyAA. Experimental insights into fhe fubulointerstitial xisease accompanying primary glomerular lesions. J Am Soc Nephrol1994;5:1273–87.
88.
EhrenreichH, AndersonRW, FoxCH, RieckmannP, HoffmanGS, TravisWD, ColiganJE, KehrlJH, FauciAS. Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med1990;172:1741–8.
89.
KohanDE. Endothelin synthesis by rabbit renal tubule cells. Am J Physiol1991;261:F221–6.
90.
IshiiK, ChangB, KerwinJFJr, WagenaarFL, HuangZ, MuradF.Formation of endothelium-derived relaxing factor in porcine kidney epithelial LLC-PK, cells: an intra-and intercellular messenger for activation of soluble guanylate cyclase. J Pharm Exp Therap1991;256:38–43.
ZagerRA. Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock. Kidney Int1991;39:111–9.
93.
ShoskesDA, ParfreyNA, HalloranPF. Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse. Transplantation1990;49:201–7.
94.
ShackletonC.Effect of recovery from ischemic injury on class I and class II MHC antigen expression. Transplantation1990;49:641–4.
95.
FineLG, NormanJT, OngA.Cell-cell cross talk in the pathogenesis of renal interstitial fibrosis. Kidney Int1995;47:48–50.
96.
KleinmanJG, WorcesterEM, BeshenskyAM, SheridanAM, BonventreJV, BrownD.Upregulation of osteopontin expression by ischemia in rat kidney. Ann NY Acad Sci1995;760:321–3.
97.
AlfreyAC. Role of iron and oxygen radicals in the progression of chronic renal failure. Am J Kidney Dis1994;23:183–7.
98.
SponselHT, AlfreyAC, HammondWS, DurrJA, RayC, AndersonRJ. Effect of iron on renal tubular epithelial cells. Kidney Int1996;50:436–44.
99.
NankivellBJ, BoadleRA, HarrisDCH. Iron accumulation in human chronic renal disease. Am J Kidney Dis1992;20:580–4.
100.
AlfreyAC, FromentDH, HammondWS. Role of iron in the tubulo-interstitial injury in nephrotoxic serum nephritis. Kidney Int1989;36:753–9.
101.
NankivellBJ, TayY, BoadleRA, HarrisDCH. Dietary protein alters tubular iron accumulation after partial nephrectomy. Kidney Int1994;45:1006–13.
102.
HarrisD, ChenJ.Monocyte chemoattractant protein-1 (MCP-1) mRNA expression in response to protein in rat proximal tubule cells in culture. J Am Soc Nephrol1995;6:1015A.
103.
SacksSH, ZhouW, SheerinNS. Complement synthesis in the injured kidney. does it have a role in immune complex glomerulonephritis?J Am Soc Nephrol1996;7:2314–19.
SchulzeM, DonadioJV, PruchnoCJ, BakerPJ, JohnsonRJ, StahlRAK, WatkinsS, MartinDC, WurznerR, GotzeO, CouserWJ. Elevated urinary excretion of the C5b-9 complex in membranous nephropathy. Kidney Int1991;40:533–8.
106.
OgrodowskiJL, HebertLA, SedmakD, CosioFG, TameriusJ, KolbW.Measurement of SC5b-9 in urine un patients with the nephrotic syndrome. Kidney Int1991;40:1141–7.
107.
CamussiG, RotunnoM, SegoloniG, BrentjensJR, AndresGA. In vitro alternative pathway activation of complement by the brush border of proximal tubules of normal rat kidney. J Immunol1982;128:1659–63.
108.
BrooimansRA, StegmannAPA, van DorpWT, van der ArkAAJ, van der WoudeFJ, Van esLA, DahaMR. Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. J Clin Invest1991;88:379–84.
109.
WelchTR, BeischelLS, WitteDP. Differential expression of complement C3 and C4 in the human kidney. J Clin Invest1993;92:1451–8.
110.
WelchTR, BeischelLS, FrenzkeM, WitteD.Regulated expression of complement factor B in the human kidney. Kidney Int1996;50:521–5.
111.
ZhouW, AndrewsPA, WangY, WolffJ, PrattJ, HartleyBR, VerroustP, SacksSH. Evidence for increased synthesis of complement C4 in the renal epithelium of rats with passive Heymann nephritis. J Am Soc Nephrol1997;8:214–22.
112.
RustomR, JacksonMJ, CritchleyM, BoneJM. Tubular metabolism of aprotinin 99mTc And urinary ammonia: effects of proteinuria. Miner Electrolyte Metab1992;18:108–12.
113.
NathKA, HostetterMK, HostetterTH. Ammonia-complement interaction in the pathogenesis of progressive renal injury. Kidney Int1989;36 (27 Suppl):S52–4.
114.
NathKA, HostetterMK, HostetterTH. Pathophysiology of chronic tubulo-interstitial disease in rats: interaction of dietary acid load, ammonia, and complement component C3. J Clin Invest1985;76:667–75.
115.
Gharaee-KermaniM, WigginsR, WolberF, GoyalM, PhanSH. Fibronectin is the major fibroblast chemoattractant in rabbit antiglomerular basement membrane disease. Am J Pathol1996;148:961–71.
116.
PeruzziL, TrusolinoL, AmoreA, GianoglioB, CirinaP, BassoG, EmancipatorSN, MarchisioPC, CoppoR.Tubulointerstitial responses in the progression of glomerular diseases: albuminuria modulates αβ, iIntegrin. Kidney Int1996;50:1310–20.
117.
KohanDE. Endothelins in the normal and diseased kidney. Am J Kid Dis1997;29:2–26.
118.
KeaneWF. Lipids and the kidney. Kidney Int1994;46:910–20.
119.
LeeHS, KimBC, KimYS, ChoiKH, ChungHK. Involvement of oxidation in LDL-induced collagen gene regulation in mesangial cells. Kidney In1996;50:1582–90.
120.
GomoZAR, HendersonLO. High-density lipoprotein apolipoproteins in urine: II. enzyme-linked immunoassay of apolipoprotein A-1. Clin Chem1988;34:1781–6.
121.
GroneH, HohbachJ, GroneEF. Modulation of glomerular sclerosis and interstitial fibrosis by native and modified lipoproteins. Kidney Int1996;49 (54 Suppl):S18–S22.
122.
EddyAA. Expression of genes that promote renal interstitial fibrosis in rats with proteinuria. Kidney Int1996;49 (54 Suppl):S49–S54.
123.
EddyAA. Interstitial inflammation and fibrosis in rats with dietiInduced hypercholesterolemia. Kidney Int1996;50:1139–49.
124.
El NahasAM, Muchaneta-KubaraEC, ZhangGZ, AdamA, GoumenosD.Phenotypic modulation of renal cells during experimental and clinical renal scarring. Kidney Int1996;49 (54 Suppl):S23–7.
125.
DiamondJR, van GoorH, DingG, EngelmyerE.Myofibroblasts in experimental hydronephrosis. Am J Pathol1995;146:121–9.
126.
AlpersCE, HudkinsKL, FloegeJ, JohnsonRJ. Human renal cortical interstitial cells with some features of smooth muscle cells participate in tubulointerstitial and crescentic glomerular injury. JASN1994;5:201–10.
127.
GoumenosDS, BrownCB, ShortlandJ, El NahasAM. Myofibroblasts, predictors of progression of mesangial IgA nephropathy?Nephrol Dial Transpl1994;9:1418–25.
128.
HewitsonTD, BeckerGJ. Interstitial myofibroblasts In IgA glomerulonephritis. Am J Nephrol1995;15:111–7.
129.
PichlerRH, HugoC, ShanklandSJ, ReedMJ, BassukJA, AndohTF, LombardiDM, SchwartzSM, BennettWM, AlpersCE, SageEH, JohnsonRJ, CouserWG. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney Int1996;50:1978–89.
130.
ZhangG, MoorheadPJ, El NahasAM. Myofibroblasts and the progression of experimental glomerulonephritis. Exp Nephrol1995;3:308–18.
131.
NouwenEJ, VerstrepenWA, BuyssensN, ZhuM, DeBroeME. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab Invest1994;70:479–93.
132.
WigginsR, GoyalM, MerrittS, KillenPD. Vascular adventitial cell expression of collagen I messenger ribonucleic acid in antiglomerular basement membrane sntibody-induced crescentic nephritis in the rabbit. Lab Invest1993;68:557–65.
133.
AlpersCE, SeifertRA, HudkinsKL, JohnsonRJ, Bowen-PopeDF. PDGF-receptor localizes to mesangial, parietal epithelial, and interstitial cells in human and primate kidneys. Kidney Int1993;43:286–94.
134.
GesualdoL, Di PaoloS, MianiS, PinzaniM, GrapponeC, RanieriE, PannaraleG, SchenaFP. Expression of platelet-derived growth factor receptors in normal and siseased human kidney. J Clin Invest1994;94:50–8.
135.
FellstromB, KlareskogL, HeldinCH, LarssonE, RonnstrandL, TerracioL, TufvesonG, WahlbergJ, RubinK.Platelet-derived growth factor receptors in the kidney-upregulated expression in inflammation. Kidney Int1989;36:1099–102.
136.
TangWW, UlichTR, LaceyDL, HillDC, QiM, KaufmanSA, Tarp VanGY, LeyJE Yee JS. Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol1996;148:1169–80.
137.
EddyAA. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol1996;7:2495–508.
138.
BorderW, NobleN.Transforming growth factor β in tissue fibrosis. N Engl J Med1994;331:1286–92.
139.
SharmaK, ZiyadehFN. The emerging role of transforming growth factor-β in kidney diseases. Am J Physiol1994;266:F829–42.
140.
AlvarezRJ, SunMJ, HavertyTP, IozzoRV, MyersJC, NeilsonEG. Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int1992;41:14–23.
141.
AtkinsRC, Nikolic-PatersonDJ, SongQ, LanHY. Modulators of crescentic glomerulonephritis. JASN1996;7:2271–8.
142.
PalmerBF. Nephrotic edema-pathogenesis and treatment. Am J Medical Sciences1993;306:53–67.
143.
GhiggeriGM, GinevriF, CandianoG, OlegginiR, PerfumoF, QueiroloC, GusmanoR.Characterization of cationic albumin in minimal change nephropathy. Kidney Int1987;32:547–53.
144.
OkudaS, OochiN, WakisakaM, KanaiH, TamakiK, NagaseS, OnoyamaK, FujishimaM.Albuminuria is not an aggravating factor in experimental focal glomerulosclerosis and hyalinosis. J Lab Clin Med1992;119:245–53.
145.
LewisEJ, HunsickerLG, BainRP, RohdeRD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med1993;329:1456–62.
146.
VibertiG, MorgenenCE, GroopLC, PaulsJF. Effect of captopril on progression to clinical proteinuria in patients with insulin dependent diabetes mellitus and microalbuminuria. JAMA1994;271:275–9.
147.
BakrisGL, CopleyJB, VicknairN, SadlerR, LeurgansS.Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy. Kidney Int1996;50:1641–50.
148.
MaschioG, AlbertiD, JaninG, LocatelliF, MannJFE, MotoleseM, PonticelliC, RitzE, ZucchelliP.Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N Engl J Med1996;334:939–45.
149.
ZellerK, WhittakerE, SullivanL, RaskinP, JacobsonHR. Effect of restricting dietary protein on the progession of renal failure in patients with insulin-dependent diabetes mellitus. N Engl J Med1991;324:78–84.
150.
FouqueD, LavilleM, BoisselJP, ChiffletR, LabeeuwM, ZechPY. Controlled low protein diets in chronic renal insufficiency. Meta-Analysis. Brit Med J1992;304:216–20.
151.
PedriniMT, LeweyAS, LauJ, ChalmerTC, WangPH. The effect of dietary protein restriction on the progression of diabetic and non-diabetic renal diseases: a meta-analysis. Ann Intern Med1996;124:627–32.
152.
BrennerBM, LawlerEV, MackenzieHS. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int1996;49:1774–7.
153.
ter WeePM, EpsteinM.Angiotensin-converting enzyme inhibitors and progression of nondiabetic chronic renal disease. Arch Intern Med1993;153:1749–59.
154.
KasiskeBL, KalilRSN, MaJZ, LiaoM, KeaneWF. Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta regression analysis. Ann Intern Med1993;118:129–38.
155.
ZojaC, DonadelliR, CornaD, TestaD, FacchinettiD, MaffiF, LuzzanaE, ColosioV, BertaniT, RemuzziG.The renoprotective properties of angiotensin-converting enzyme inhibitors in a chronic model of membranous nephropathy are solely due to the inhibition of angiotension II: evidence based on comparative studies with a receptor antagonist. Am J Kidney Dis1997;29:254–64.
EgidoJ.Vasoactive hormones and renal aclerosis. Kidney Int1996;49:578–97.
158.
WolfG, MuellerE, StahlRAK, ZiyadehFN. Angiotensin II-induced hypertrophpy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-β. J Clin Invest1993;92:1366–72.
159.
RosenbergME, SmithLJ, Correa-RotterR, HostetterTH. The paradox of the renin angiotensin system in chronic renal disease. Kidney Int1994;45:403–10.
160.
DiamondJR. Macrophages and progressive renal disease in experimental hydronephrosis. Am J Kidney Dis1995;26:133–40.
161.
DiamondJR, Kees-FoltsD, RicardoSD, PruznakA, EufemioM.Early aAnd persistent up-regulated expression of renal cortical osteopontin in experimental hydronephrosis. Am J Pathol1995;146:1455–66.
162.
RicardoSD, LevinsonME, DeJosephMR, DiamondJR. Expression of adhesion molecules in rat renal cortex during experimental hydronephrosis. Kidney Int1996;50:2002–10.
163.
KlahrS, IshidoyaS, MorrisseyJ.Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy. Am J Kidney Dis1995;26:141–6.
164.
IshidoyaS, MorrisseyJ, McCrackenR, KlahrS.Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats wtih obstructive nephropathy. Kidney Int1996;49:1110–9.
165.
PimentelJLJr, MonteroA, WangS, YosipivI, Ell-DahrS, Martinez-MaldonadoM.Sequential changes in renal expression of renin-angiotensin system genes in acute unilateral ureteral obstruction. Kidney Int1995;48:1247–53.
166.
Ruiz-OrtegaM, GonzalezS, SeronD, CondomE, BustosC, LargoR, GonnzalezE, OrtizA, EgidoJ.ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis. Kidney Int1995:48:1778–91.
167.
DiamondJR, AndersonS.Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Am J Pathol1990;137:1323–32.
168.
NormanJT, GallegoC, BridgemanDA, FogoA, FineLG. Enalapril ameliorates interstitial fibrosis in the remnant kidney of the rat. J Am Soc Nephrol1992;3:746.
169.
InserraF, RomanoLA, de CavanaghEMV, ErcoleL; FerderLF, GomezRA. Renal interstitial sclerosis in aging: effects of enalapril and nifedipine. J Am Soc Nephrol1996;7:676–80.
170.
BennettWM, DeMattosA, MeyerMM, AndohT, BarryJM. Chronic cyclosporine nephropathy: the achilles' heel of immunosuppressive therapy. Kidney Int1996;50:1089–100.
171.
KeilaniT, SchlueterWA, LevinML, BatlleDC. Improvement of lipid abnormalities associated with proteinuria using fosinopril, an angiotensin-converting enzyme inhibitor. Ann Intern Med1993;118:246–54.
172.
FukuiM, NakamuraT, EbiharaI, NagaokaI, TominoY, KoideH.Low-protein diet attenuates increased gene expression of platelet-derived growth factor and transforming growth factor-β in experimental glomerular sclerosis. J Lab Clin Med1993;121:224–34.