Cytokines in Host Defense against Pneumonia

Mandell GL , Douglas RG , Bennett JE . Principles and practice of infectious diseases. New York: Churchill Livingstone, 1990:2340.

Wunderink R. Ventilator-associated pneumonia. Failure to respond to antibiotic therapy. Clin Chest Med 1995;16:173–93.

Nelson S , Mason C , Pierce A. Pathophysiology of pneumonia. Clin Chest Med 1995;16:1–12.

Toews GB , Gross GN , Pierce AK . The relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice. Am Rev Respir Dis 1979;120:559–66.

Paul W. Fundamental immunology. New York: Raven Press, 1993:1490.

Thomson A. The cytokine handbook. London: Academic Press, 1994:615.

Strieter RM , Kunkel SL , Bone RC . Role of tumor necrosis factoralpha in disease states and inflammation. Crit Care Med 1993;21:S447–63.

Le J , Vilcek J. Tumor necrosis factor and interleukin-1: cytokines with multiple overlapping biological activites. Lab Invest 1987;56:234–48.

Shalaby MR , Espevik T , Rice GC , Ammann AJ , Figari IS , Ranges GE Palladino MA. The involvement of human tumor necrosis factors-alpha and beta in the mixed lymphocyte reaction. J Immunol 1988;141:499–503.

Yokota S , Geppert TD , Lipsky PE . Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha. J Immunol 1988;140:531–6.

Zucali JR , Elfenbein GJ , Barth KC , Dinarello CA . Effects of human interleukin-1 and human tumor necrosis factor on human T lymphocyte colony formation. J Clin Invest 1987;80:772–7.

Scheurich P , Thoma B , Ucer U , Pfizenmaier K. Immunoregulatory activity of recombinant human tumor necrosis factor (TNF): induction of the TNF receptors on human T cells and TNF-mediated enhancement of T cell responses. J Immunol 1987;138:1786–90.

Ranges GE , Figari IS , Espevik T , Palladino MA . Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor-alpha. J Exp Med 1987;166:991–8.

Dehoux M , Boutten A , Ostimelli J , Seta N , Dombret M , Crestani B Deschenes M, Trouillet J , Aubier M. Compartmentalized cytokine production within the human lung in unilateral pneumonia. Am J Respir Crit Care Med 1994;150:710–6.

Laichalk L , Kunkel S , Streiter R , Danforth J , Bailie M , Standiford T. Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia. Infect Immun 1996;64:5211–8.

Gosselin D , DeSanctis J , Boule M , Skamene E , Matouk C , Radzioch D. Role of tumor necrosis factor-alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa. Infect Immun 1995;63:3272–8.

Brieland J , Remick D , Freeman P , Hurley M , Fantone J , Engleberg N. In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor-alpha and nitric oxide. Infect Immun 1995;63:3253–8.

Nelson S , Bagby G , Summer W. Anti-tumor necrosis factor-alpha antibody suppresses pulmonary antibacterial defenses. Am Rev Respir Dis 1991;143S:393.

Kolls J , Beck J , Nelson S , Summer W , Shellito J. Alveolar macrophages release of tumor necrosis factor during murine Pneumocystis carinii pneumonia. Am J Respir Cell Mol Biol 1993;8:370–6.

Orme IM . Immune responses in animal models. Curr Top Microbiol Immunol 1996;215:181–96.

Huffnagle GB , Toews GB , Burdick MD , Boyd MB , McAllister KS McDonald RA, Kunkel SL , Strieter RM . Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans. J Immunol 1996;157:4529–36.

Huffnagle GB , Chen GH , Curtis JL , McDonald RA , Strieter RM , Toews GB . Downregulation of the afferent phase of T cell-mediated immunity and pulmonary inflammation by a high melanin-producing strain of C neoformans. J Immunol 1995;155:3507–16.

Aguirre K , Havell EA , Gibson GW , Johnson LL . Role of tumor necrosis factor and gamma interferon in acquired resistance to Cryptococcus neoformans in the central nervous system of mice. Infect Immun 1995;63:1725–31.

Collins HL , Bancroft GJ . Cytokine enhancement of complement-dependent phagocytosis by macrophages: synergy of tumor necrosis factoralpha and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans. Eur J Immunol 1992;22:1447–54.

Vecchiarelli A , Retini C , Pietrella D , Monari C , Tascini C , Beccari T , Kozel TR . Downregulation by cryptococcal polysaccharide of tumor necrosis factor-alpha and interleukin-1 beta secretion from human monocytes. Infect Immun 1995;63:2919–23.

Levitz SM , Tabuni A , Kornfeld H , Reardon CC , Golenbock DT . Production of tumor necrosis factor-alpha in human leukocytes stimulated by Cryptococcus neoformans. Infect Immun 1994;62:1975–81.

Naslund PK , Miller WC , Granger DL . Cryptococcus neoformans fails to induce nitric oxide synthase in primed murine macrophage-like cells. Infect Immun 1995;63:1298–304.

Kolls J , Nelson S , Summer W. Recombinant cytokines and pulmonary host defense. Am J Med Sci 1993;306:330–5.

Nelson S. Overview of granulocyte colony-stimulating factor in bacterial infections in the non-neutropenic host. Clin Infect Dis 1991;143S:398–410.

Chen GH , Curtis JL , Mody CH , Christensen PJ , Armstrong LR , Toews GB . Effect of granulocyte-macrophage colony-stimulating factor on rat alveolar macrophage anticryptococcal activity in vitro. J Immunol 1994;152:724–34.

Lister P , Gentry M , Preheim L. Granulocyte colony-stimulating factor protects control rats but not ethanol-fed rats from fatal pneumococcal pneumonia. J Infect Dis 1993;168:922–6.

Preheim L , Snitily M , Gentry M. Effects of granulocyte colony-stimulating factor in cirrhotic rats with pneumococcal pneumonia. J Infect Dis 1996;174:225–8.

Smith W , Sumnicht G , Sharpe R , Samuelson D , Millard F. Granulocyte colony-stimulating factor versus placebo in addition to penicillin G in randomized blinded study of gram-negative pneumonia sepsis: analysis of survival and multisystem organ failure. Blood 1995;86:1301–9.

Blanchard DK , Michelini NM , Pearson CA , McMillen S , Djeu JY . Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by monocytes and large granular lymphocytes stimulated with Mycobacterium avium-M intracellulare: activation of bactericidal activity by GM-CSF. Infect Immun 1991;59:2396–402.

Denis M. Tumor necrosis factor and granulocyte-macrophage colony-stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M avium: killing effector mechanism depends on the generation of reactive nitrogen intermediates. J Leukoc Biol 1991;49:380–7.

Bermudez LE , Young LS . Recombinant granulocyte-macrophage colony-stimulating factor activates human macrophages to inhibit growth or kill Mycobacterium avium complex. J Leukoc Biol 1990;48:67–73.

Levitz SM . Activation of human peripheral blood mononuclear cells by interleukin-2 and granulocyte-macrophage colony-stimulating factor to inhibit Cryptococcus neoformans. Infect Immun 1991;59:3393–7.

Mandujano J , D'Souza N , Nelson S , Summer W , Beckerman R , Shellito J. Granulocyte-macrophage colony-stimulating factor and Pneumocystis carinii pneumonia in mice. Am J Respir Crit Care Med 1995;151:1233–8.

Jenson W , Rose R , Wasserman A , Kalb T , Anton K , Remold H. In vitro activation of the antibacterial activity of human pulmonary macrophages by recombinant gamma interferon. J Infect Dis 1987;155:574–7.

Hoag KA , Street NE , Huffnagle GB , Lipscomb MF . Early cytokine production in pulmonary Cryptococcus neoformans infections distinguishes susceptible and resistant mice. Am J Respir Cell Mol Biol 1995;13:487–95.

Huffnagle GB , Lipscomb MF , Lovchik JA , Hoag KA , Street NE . The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leukoc Biol 1994;55:35–42.

Lovchik JA , Lyons CR , Lipscomb MF . A role for gamma interferon-induced nitric oxide in pulmonary clearance of Cryptococcus neoformans. Am J Respir Cell Mol Biol 1995;13:116–24.

Mody CH , Tyler CL , Sitrin RG , Jackson C , Toews GB . Interferon-gamma activates rat alveolar macrophages for anticryptococcal activity. Am J Respir Cell Mol Biol 1991;5:19–25.

Beck J , Liggitt H , Brunette E , Fuchs H , Shellito J , Debs R. Reduction in intensity of Pneumocystis carinii pneumonia in mice by aerosol administration of gamma interferon. Infect Immun 1991;59:3859–62.

Skerrett S , Martin T. Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis. Am J Respir Crit Care Med 1994;149:50–8.

Oppenheim JJ , Zachariae COC , Mukaida N , Matsushima K. Properties of the novel proinflammatory supergene “intercrine” cytokine family. Annu Rev Immunol 1991;9:617–47.

Huffnagle GB , Toews GB . Mechanisms of macrophage recruitment into infected lungs. In: Lipscomb MF , Russell S , eds. Lung macrophages and dendritic cells. New York: Marcel Dekker, Inc., 1996:373–407.

Huffnagle GB , Strieter RM , Kunkel SL , Toews GB , Standiford TJ . The role of chemokines in pneumonia. In: Koch AE , Strieter RM , eds. Chemokines in disease. Austin: R.G. Landes Company, 1996:151–68.

Greenberger M , Strieter RM , Kunkel SL , Danforth J , Laichalk L , McGillicuddy D , Standiford TJ . Neutralization of MIP-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia. J Infect Dis 1996;173:159–65.

Huffnagle GB , Strieter RM , Standiford TJ , McDonald RA , Burdick MD , Kunkel SL , Toews GB . The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection. J Immunol 1995;155:4790–7.

Howard M , O'Garra A , Ishida H , Malefyt R , De Vries J. Biological properties of interleukin-10. J Clin Immunol 1992;12:239–47.

Chehimi J , Trinchieri G. Interleukin-12: a bridge between innate resistence and adaptive immunity with a role in infection and acquired immunodeficiency. J Clin Immunol 1994;14:149–59.

Brunde M. Interleukin-12. J Leukoc Biol 1994;55:280–8.

Gazzinelli R , Hieny S , Wynn T , Wolf S , Sher A. Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-gamma by an intracellular parasite and induces resistance in T-cell deficient hosts. Proc Natl Acad Sci USA 1993;90:6115–9.

Heinzel F , Schoenhaut D , Rerko R , Rosser L , Gately M. Recombinant interleukin-12 cures mice infected with Leischmania major. J Exp Med 1993;177:1505–9.

Flynn J , Goldstein M , Triebold K , Sypek J , Wolf S , Bloom B. Interluekin-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 1995;155:2515–24.

Stevenson M , Tam M , Wolfeand S , Sher A. Interleukin-12-induced protection against blood-stage plasmodium chabaudi requires IFN-γ and TNF-α and occurs via a nitric oxide-dependent mechanism. J Immunol 1995;155:2545–56.

Wagner R , Steinberg H , Brown J , Czuprynski C. Recombinant interleukin-12 enhances resistance to mice to Listeria monocytogenes infection. Microb Pathog 1994;17:175–86.

Cooper AM , Roberts AD , Rhoades ER , Callahan JE , Getzy DM , Orme IM . The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 1995;84:423–32.

Zhou P , Sieve MC , Bennett J , Kwon-Chung KJ , Tewari RP , Gazzinelli RT , Sher A , Seder RA . Interleukin-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma. J Immunol 1995;155:785–95.

Kawakami K , Tohyama M , Xie Q , Saito A. Interleukin-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans. Clin Exp Immunol 1996;104:208–14.

Greenberger M , Kunkel SL , Strieter RM , Lukacs N , Bramson J , Gauldie J , Graham F , Hitt M , Danforth J , Standiford TJ . Interleukin-12 gene therapy protects mice in lethal Klebsiella pneumonia. J Immunol 1996;157:3006–12.

Laichalk L , Danforth J , Standiford T. Interleukin-10 inhibits neutrophil phagocytic and bacterial activity. FEMS Immunol Med Microbiol 1996;15:181–7.

Oswald I , Wynn T , Sher A. Interleukin-10 inhibits macrophage microbicidal activity by blocking endogenous production of tumor necrosis factor-a required as a costimulatory factor for interferon-gamma-induced activation. Proc Natl Acad Sci USA 1992;89:8676–80.

Kasama T , Strieter R , Lukacs NW , Burdick MD , Kunkel SL . Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol 1994;152:3559–69.

Cassatella M , Meda L , Bonora S , Ceska M , Constantin G. Interleukin-10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1ß in mediating the production of IL-8 triggered by lipopolysaccaride. J Exp Med 1993;178:2207–11.

Rolph P , Nakoinz I , Sampson-Johannes A , Fong S , Lowe D , Min H In L. Interleukin-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J Immunol 1992;148:808–14.

Standiford T , Strieter R , Lukacs N , Kunkel S. Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J Immunol 1995;155:2222–9.

Howard M , Muchamuel T , Andrade S , Menon S. Interleukin-10 protects mice from lethal endotoxemia. J Exp Med 1993;177:1205–8.

Greenberger M , Strieter R , Kunkel S , Danforth J , Goodman R , Standiford T. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J Immunol 1995;155:722–9.

van der Poll T , Marchant A , Keogh C , Goldman M , Lowry S. Interleukin-10 impairs host defense in murine pneumococcal pneumonia. J Infect Dis 1996;174:994–1000.

Bermudez LE , Champsi J. Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administrationof anti-IL-10 antibody is associated with enhanced resistance to infection in mice. Infect Immun 1993;61:3093–7.

Vecchiarelli A , Retini C , Monari C , Tascini C , Bistoni F , Kozel TR . Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes. Infect Immun 1996;64:2846–9.

Davies J. Inactivation of antibiotics and dissemination of resistance genes. Science 1994;264:375–82.

Nelson S , Farkas S , Fitheringham N , Ho H , Marrie T , Movahhed H. Filgrastim in the treatment of hospitalized patients with community-acquired pneumonia (CAP). Am J Resp Crit Care Med 1996;153:A535.

Interleukin-12 deaths: explanation and the puzzle [news and comment]. Science 1995;270:908.

Tracey K , Beutler B , Lowry S , Cerami A. Shock and tissue injury induced by recombinant human cachectin. Science 1986;234:470–4.

Bramson J , Hitt M , Gallichan W , Rosenthal K , Gauldie J , Graham F. Construction and characterization of an adenovirus expressing IL-12. Hum Gene Ther 1995;7:333–40.

Kolls J , Lei D , Nelson S , Summer W , Greenberg S , Beutler B. Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host defense. J Infect Dis 1995;171:570–5.