Effects of magnesium and potassium on insulin resistance and blood sugar level among insomniac patients with diabetes mellitus—A randomized controlled trial

Abstract

The aim of this study is to compare the effect of magnesium and potassium on insulin resistance and blood sugar levels among insomniac patients with diabetes mellitus. A randomized controlled study was conducted on 320 subjects enrolled in placebo (T1), Magnesium (T2), Potassium (T3), and Magnesium + Potassium (T4) treatment groups. Pre- and post-trial blood sugar and insulin levels were analyzed through blood. Insulin resistance was calculated by the homeostatic model assessment for insulin resistance (HOMA-IR). Analysis was performed in IBM SPSS^® version 25.0. HOMA-IR analysis showed that pretreatment mean of T4 (Magnesium + Potassium group) was 3.01 ± 0. 54, and post-treatment mean was 2.54 ± 0.29, showing a significant reduction (p = 0.001). There was a significant association among post-HOMA-IR scores of treatment groups (p = 0.001). Fasting blood sugar levels showed that all groups, except placebo, had significant differences in levels (p = 0.001). A comparison between treatment groups concluded that blood sugar levels were associated with significant differences (p = 0.001). The study suggests that magnesium alone and magnesium coupled with potassium supplementation assist insomniac diabetics more effectively to regulate insulin resistance and increased blood sugar levels.